Entero-hepatic Circulation of SM-10888 in the Rat: Elucidation of the Participating Major Metabolites

The entero-hepatic circulation of 9-amino-8-fluoro-1, 2, 3, 4-tetrahydro-2, 4-methanoacridine citrate (SM-10888) in rats was investigated after oral administration and/or duodenal infusion of a pooled bile sample. 1. Pooled bile obtained from a rat receiving an oral dose of 14C-SM-10888 (5 mg/kg) wa...

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Veröffentlicht in:	Drug Metabolism and Pharmacokinetics 1994, Vol.9(5), pp.596-602
Hauptverfasser:	YABUKI, Masashi, IBA, Kazuhiko, NAKATSUKA, Iwao, YOSHITAKE, Akira
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Entero-hepatic circulation Metabolism Rats SM-10888
Online-Zugang:	Volltext
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