Metabolic Fate of Nifedipine Suppository in Rats

14C-Nifedipine suppository was administered intrarectally (i.r.) in rat, in order to investigate its absorption, distribution, metabolism and excretion, comparing with the data after intravenous (i.v.) or oral (p.o.) administration of 14C nifedipine solution. Also the metabolic fate was investigated...

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Veröffentlicht in:Drug Metabolism and Pharmacokinetics 1992, Vol.7(2), pp.257-272
Hauptverfasser: HATORI, Akiko, MUKAI, Shin, HASEGAWA, Shinichi, MOMOSE, Yuko, SHIGEMATSU, Akiyo, TAKAHASHI, Kaoru, YOKOYA, Fusayuki, IMAI, Eiji
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