Prediction of Oral Absorption of Cephalosporins in Humans

Orally active cephalosporin antibiotics are known to be absorbed from the small intestine via the oligopeptide transporter (PepT1). Although several methods have been proposed for the prediction of oral absorption in humans, no in vitro method has been established to predict oral absorption of the d...

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Veröffentlicht in:	Drug Metabolism and Pharmacokinetics 2000, Vol.15(2), pp.196-200
Hauptverfasser:	KOHDA, Rikako, LI, Yin-Hua, SHITARA, Yoshihisa, ITO, Kiyomi, TSUDA, Yasuyuki, YAMADA, Hideo, ITOH, Tomoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 cells Cephalosporin antibiotics Intestinal absorption Oligopeptide transporter Prediction Rat intestinal brush border membrane vesicles
Online-Zugang:	Volltext
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