Metabolic Fate of Menaquinone-4 in Dogs (II): Absorption, Distribution, Metabolism and Excretion after Repeated Oral Administration

[14C]menaquinone-4, a therapeutic agent for osteoporosis, was administered orally to male dogs at a dose of 4 mg/kg once a day for seven days, and the absorption, distribution, metabolism and excretion were investigated. 1. The mean plasma concentration of radioactivity reached a maximum level at 1....

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Veröffentlicht in:	Drug Metabolism and Pharmacokinetics 1997/02/28, Vol.12(1), pp.58-67
Hauptverfasser:	SANO, Yoshihisa, TADANO, Kyoichi, KIKUCHI, Kiyomi, KANEKO, Kazuhiro, YUZURIHA, Teruaki, KIMURA, Tomonori, MURAYAMA, Yoshihiko
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Absorption Bone Distribution Dogs Excretion Menaquinone-4 Metabolism Oral Osteoporosis Vitamin K γ-carboxylase
Online-Zugang:	Volltext
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