Pharmacokinetics of Levofloxacin, a New Fluoroquinolone Agents, after Instillation of 0.5% 14C-levofloxacin Ophthalmic Solution to Pigmented Rats

The pharmacokinetics of levofloxacin (LVFX) was investigated after a single or repeated topical application of 0.5% 14C-LVFX ophthalmic solution to pigmented rats. In the case of repeated application, the ophthalmic solution was instilled 3 times a day for 14 days (total 40 times). 1. The radioactiv...

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Veröffentlicht in:	Drug Metabolism and Pharmacokinetics 1997/08/30, Vol.12(4), pp.281-288
Hauptverfasser:	IBUKI, Hajime, OKAMOTO, Tomoyuki, OKA, Koji, OTA, Atsutoshi, TAKASHINA, Hideo, KAWASHIMA, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Levofloxacin Melanin affinity Ophthalmic instillation Pharmacokinetics Pigmented rat
Online-Zugang:	Volltext
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