(-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells

We reported that (-)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human breast cancer cells, in which GADD45γ, a novel tumor suppressor gene, was induced. Mechanistically, topoisomerase IIα (Topo IIα) inhibition by (-)...

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Veröffentlicht in:	Journal of toxicological sciences 2013/08/01, Vol.38(4), pp.547-557
Hauptverfasser:	Takeda, Shuso, Nishimura, Hajime, Koyachi, Kuniyoshi, Matsumoto, Kenji, Yoshida, Kazutaka, Okamoto, Yoshiko, Amamoto, Toshiaki, Shindo, Mitsuru, Aramaki, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	(-)-Xanthatin Acetylcysteine - pharmacology Antigens, Neoplasm Antineoplastic Agents - pharmacology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology c-Fos Cell Division - genetics DNA Topoisomerases, Type II DNA-Binding Proteins - antagonists & inhibitors Etoposide - pharmacology Female Free Radical Scavengers - pharmacology Furans - pharmacology GADD45 Proteins GADD45γ Gene Expression Regulation, Neoplastic - drug effects Genes, Tumor Suppressor - drug effects Humans Intracellular Signaling Peptides and Proteins - metabolism Proto-Oncogene Proteins c-fos - metabolism Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods ROS Tumor Cells, Cultured Up-Regulation
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