Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human type 2 diabetes

The diabetic state is considered to be one of the risk factors of drug-induced liver injury (DILI) because of the lower levels of glutathione for detoxification by conjugation with drugs. Carbamazepine (CBZ) -induced hepatotoxicity in humans is rare and unpredictable with the present state of knowle...

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Veröffentlicht in:	Fundamental Toxicological Sciences 2019, Vol.6(8), pp.287-297
Hauptverfasser:	Takahashi, Tadakazu, Matsuura, Chizuru, Toyoda, Kaoru, Suzuki, Yusuke, Yamada, Naohito, Kobayashi, Akio, Sugai, Shoichiro, Shimoi, Kayoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbamazepine Glutathione Hepatotoxicity SDT fatty rats Type2 diabetes
Online-Zugang:	Volltext
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