Comparison of stabilities of nitrenium ions and in vitro and in vivo genotoxic potential, between four aniline derivatives

Stabilities of nitrenium ions estimated by in silico analyses and in vitro and in vivo genotoxicity were compared for four aniline derivatives, 2-chloro-4-methylaniline (2C4MA), 4-chloro-2-methylaniline (4C2MA), 2-chloro-4,5-difluoroaniline (2C4,5DFA) and 4-trifluoromethylaniline (4TFMA). The AM1 va...

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Veröffentlicht in:	Fundamental Toxicological Sciences 2018/02/21, Vol.5(1), pp.21-32
Hauptverfasser:	Suzuki, Hidekazu, Ninoseki, Takuya, Hayashi, Ayumi, Hase, Yasunori, Matsui, Takuya, Naito, Masaru, Sugai, Shoichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	AM1 Ames test Aniline derivatives Comet assay Nitrenium ions
Online-Zugang:	Volltext
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