Apoptosis and Mitochondrial Dysfunction in Human Chondrocytes Following Exposure to Lidocaine, Bupivacaine, and Ropivacaine

BACKGROUND:Several mechanisms have been proposed to explain toxicity of local anesthetics to chondrocytes, including the blockade of potassium channels and mitochondrial injury. The purposes of this investigation were to study the effects of lidocaine, bupivacaine, and ropivacaine on human chondrocy...

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Veröffentlicht in:	Journal of bone and joint surgery. American volume 2010-03, Vol.92 (3), p.609-618
Hauptverfasser:	Grishko, Valentina, Xu, Min, Wilson, Glenn, Pearsall, Albert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - toxicity Analysis of Variance Anesthetics, Local - toxicity Antiarythmic agents Apoptosis - drug effects Biological and medical sciences Blotting, Western Bupivacaine - toxicity Cardiovascular system Cartilage, Articular - drug effects Cartilage, Articular - enzymology Cells, Cultured Chondrocytes - drug effects Chondrocytes - enzymology Diseases of the osteoarticular system Female Flow Cytometry Humans Lidocaine - toxicity Male Medical sciences Middle Aged Mitochondria - drug effects Mitochondria - enzymology Orthopedic surgery Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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