Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study
Dose-limiting neurotoxicity is the major side effect caused by oxaliplatin treatment. Optimization of oxaliplatin-containing chemotherapeutic regimens may potentially benefit advanced gastric cancer (AGC) patients. We tried to reduce the dose of oxaliplatin and add a drug to compensate for the effic...
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Veröffentlicht in: | Annals of palliative medicine 2021-12, Vol.10 (12), p.12821-12830 |
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creator | Ma, Jian Xiao, Min Li, Xiaoqian Zhao, Qiu Ye, Wei Ji, Wenjing Ling, Yang Yang, Quanliang |
description | Dose-limiting neurotoxicity is the major side effect caused by oxaliplatin treatment. Optimization of oxaliplatin-containing chemotherapeutic regimens may potentially benefit advanced gastric cancer (AGC) patients. We tried to reduce the dose of oxaliplatin and add a drug to compensate for the efficacy. This cohort study evaluated the efficacy and side effects of low-dose oxaliplatin combined with pegylated liposomal doxorubicin and S-1 (D-SOX) as first-line treatment for AGC.
64 AGC patients treated in our hospital between January 2015 and December 2018 were included in this study. Among them, 29 cases received standard S-1 and oxaliplatin (SOX) regimen, and 35 cases received D-SOX. Progression-free survival (PFS), overall survival (OS), response rate (RR), and safety were analyzed.
The median PFS was 7.0 months [95% confidence interval (CI): 5.77 to 8.23 months] in the SOX group and 9.3 months (95% CI: 8.145 to 10.45 months) in the D-SOX group (P=0.021). The median OS was 12.5 months (95% CI: 7.00 to 17.97 months) in the SOX group and 18.7 months (95% CI: 14.485 to 22.9 months) in the D-SOX group (P=0.027). The incidence of treatment-related grade III-IV adverse events (AEs) was less than 10%. The RRs to these 2 regimens were similar (P=0.609). The incidence of neurotoxicity was significantly reduced in the D-SOX group (62.8% vs. 82.7%).
Low-dose oxaliplatin combined with S-1 and pegylated liposomal doxorubicin (PLD) regimen improved OS and PFS, while exhibiting better toxicity profile as compared with standard SOX regimen for AGC. |
doi_str_mv | 10.21037/apm-21-3584 |
format | Article |
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64 AGC patients treated in our hospital between January 2015 and December 2018 were included in this study. Among them, 29 cases received standard S-1 and oxaliplatin (SOX) regimen, and 35 cases received D-SOX. Progression-free survival (PFS), overall survival (OS), response rate (RR), and safety were analyzed.
The median PFS was 7.0 months [95% confidence interval (CI): 5.77 to 8.23 months] in the SOX group and 9.3 months (95% CI: 8.145 to 10.45 months) in the D-SOX group (P=0.021). The median OS was 12.5 months (95% CI: 7.00 to 17.97 months) in the SOX group and 18.7 months (95% CI: 14.485 to 22.9 months) in the D-SOX group (P=0.027). The incidence of treatment-related grade III-IV adverse events (AEs) was less than 10%. The RRs to these 2 regimens were similar (P=0.609). The incidence of neurotoxicity was significantly reduced in the D-SOX group (62.8% vs. 82.7%).
Low-dose oxaliplatin combined with S-1 and pegylated liposomal doxorubicin (PLD) regimen improved OS and PFS, while exhibiting better toxicity profile as compared with standard SOX regimen for AGC.</description><identifier>ISSN: 2224-5820</identifier><identifier>EISSN: 2224-5839</identifier><identifier>DOI: 10.21037/apm-21-3584</identifier><identifier>PMID: 35016420</identifier><language>eng</language><publisher>China</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Cohort Studies ; Doxorubicin - analogs & derivatives ; Humans ; Oxaliplatin - therapeutic use ; Polyethylene Glycols ; Stomach Neoplasms - drug therapy</subject><ispartof>Annals of palliative medicine, 2021-12, Vol.10 (12), p.12821-12830</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-c55beff6558b9dccc9643197df898851c30d6fcdb897998643c8e1b53fdf392c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35016420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Xiao, Min</creatorcontrib><creatorcontrib>Li, Xiaoqian</creatorcontrib><creatorcontrib>Zhao, Qiu</creatorcontrib><creatorcontrib>Ye, Wei</creatorcontrib><creatorcontrib>Ji, Wenjing</creatorcontrib><creatorcontrib>Ling, Yang</creatorcontrib><creatorcontrib>Yang, Quanliang</creatorcontrib><title>Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study</title><title>Annals of palliative medicine</title><addtitle>Ann Palliat Med</addtitle><description>Dose-limiting neurotoxicity is the major side effect caused by oxaliplatin treatment. Optimization of oxaliplatin-containing chemotherapeutic regimens may potentially benefit advanced gastric cancer (AGC) patients. We tried to reduce the dose of oxaliplatin and add a drug to compensate for the efficacy. This cohort study evaluated the efficacy and side effects of low-dose oxaliplatin combined with pegylated liposomal doxorubicin and S-1 (D-SOX) as first-line treatment for AGC.
64 AGC patients treated in our hospital between January 2015 and December 2018 were included in this study. Among them, 29 cases received standard S-1 and oxaliplatin (SOX) regimen, and 35 cases received D-SOX. Progression-free survival (PFS), overall survival (OS), response rate (RR), and safety were analyzed.
The median PFS was 7.0 months [95% confidence interval (CI): 5.77 to 8.23 months] in the SOX group and 9.3 months (95% CI: 8.145 to 10.45 months) in the D-SOX group (P=0.021). The median OS was 12.5 months (95% CI: 7.00 to 17.97 months) in the SOX group and 18.7 months (95% CI: 14.485 to 22.9 months) in the D-SOX group (P=0.027). The incidence of treatment-related grade III-IV adverse events (AEs) was less than 10%. The RRs to these 2 regimens were similar (P=0.609). The incidence of neurotoxicity was significantly reduced in the D-SOX group (62.8% vs. 82.7%).
Low-dose oxaliplatin combined with S-1 and pegylated liposomal doxorubicin (PLD) regimen improved OS and PFS, while exhibiting better toxicity profile as compared with standard SOX regimen for AGC.</description><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Cohort Studies</subject><subject>Doxorubicin - analogs & derivatives</subject><subject>Humans</subject><subject>Oxaliplatin - therapeutic use</subject><subject>Polyethylene Glycols</subject><subject>Stomach Neoplasms - drug therapy</subject><issn>2224-5820</issn><issn>2224-5839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0Eoqh0xxr5Awj1I25tdqjiUakSC2AdOWO7BCVxZKel-QZ-GpdCV3Nn7pnR6CJ0Rckto4TPp7prMkYzLmR-gi4YY3kmJFenR83ICE1i_CSEUMZlrtg5GnFB6Cxn5AJ9L5su-K012DpXgYYB69bgqJ3tB-wdrv1XZny02O90XXW17qt22tn1kFTaSiMffaNrbPzOh01ZQfJfM4qDXVeNbXHVYm22uoVEr3XsQwUY9m24wxqD__Chx7HfmOESnTldRzv5q2P0_vjwtnjOVi9Py8X9KgPOVJ-BEGV6diaELJUBADXLOVVz46SSUlDgxMwcmFKquVIymSAtLQV3xnHFgI_RzeEuBB9jsK7oQtXoMBSUFL-xFinWpIp9rAm_PuDdpmysOcL_IfIfgVp2HQ</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Ma, Jian</creator><creator>Xiao, Min</creator><creator>Li, Xiaoqian</creator><creator>Zhao, Qiu</creator><creator>Ye, Wei</creator><creator>Ji, Wenjing</creator><creator>Ling, Yang</creator><creator>Yang, Quanliang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202112</creationdate><title>Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study</title><author>Ma, Jian ; Xiao, Min ; Li, Xiaoqian ; Zhao, Qiu ; Ye, Wei ; Ji, Wenjing ; Ling, Yang ; Yang, Quanliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-c55beff6558b9dccc9643197df898851c30d6fcdb897998643c8e1b53fdf392c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Cohort Studies</topic><topic>Doxorubicin - analogs & derivatives</topic><topic>Humans</topic><topic>Oxaliplatin - therapeutic use</topic><topic>Polyethylene Glycols</topic><topic>Stomach Neoplasms - drug therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jian</creatorcontrib><creatorcontrib>Xiao, Min</creatorcontrib><creatorcontrib>Li, Xiaoqian</creatorcontrib><creatorcontrib>Zhao, Qiu</creatorcontrib><creatorcontrib>Ye, Wei</creatorcontrib><creatorcontrib>Ji, Wenjing</creatorcontrib><creatorcontrib>Ling, Yang</creatorcontrib><creatorcontrib>Yang, Quanliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of palliative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jian</au><au>Xiao, Min</au><au>Li, Xiaoqian</au><au>Zhao, Qiu</au><au>Ye, Wei</au><au>Ji, Wenjing</au><au>Ling, Yang</au><au>Yang, Quanliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study</atitle><jtitle>Annals of palliative medicine</jtitle><addtitle>Ann Palliat Med</addtitle><date>2021-12</date><risdate>2021</risdate><volume>10</volume><issue>12</issue><spage>12821</spage><epage>12830</epage><pages>12821-12830</pages><issn>2224-5820</issn><eissn>2224-5839</eissn><abstract>Dose-limiting neurotoxicity is the major side effect caused by oxaliplatin treatment. Optimization of oxaliplatin-containing chemotherapeutic regimens may potentially benefit advanced gastric cancer (AGC) patients. We tried to reduce the dose of oxaliplatin and add a drug to compensate for the efficacy. This cohort study evaluated the efficacy and side effects of low-dose oxaliplatin combined with pegylated liposomal doxorubicin and S-1 (D-SOX) as first-line treatment for AGC.
64 AGC patients treated in our hospital between January 2015 and December 2018 were included in this study. Among them, 29 cases received standard S-1 and oxaliplatin (SOX) regimen, and 35 cases received D-SOX. Progression-free survival (PFS), overall survival (OS), response rate (RR), and safety were analyzed.
The median PFS was 7.0 months [95% confidence interval (CI): 5.77 to 8.23 months] in the SOX group and 9.3 months (95% CI: 8.145 to 10.45 months) in the D-SOX group (P=0.021). The median OS was 12.5 months (95% CI: 7.00 to 17.97 months) in the SOX group and 18.7 months (95% CI: 14.485 to 22.9 months) in the D-SOX group (P=0.027). The incidence of treatment-related grade III-IV adverse events (AEs) was less than 10%. The RRs to these 2 regimens were similar (P=0.609). The incidence of neurotoxicity was significantly reduced in the D-SOX group (62.8% vs. 82.7%).
Low-dose oxaliplatin combined with S-1 and pegylated liposomal doxorubicin (PLD) regimen improved OS and PFS, while exhibiting better toxicity profile as compared with standard SOX regimen for AGC.</abstract><cop>China</cop><pmid>35016420</pmid><doi>10.21037/apm-21-3584</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Antineoplastic Combined Chemotherapy Protocols - adverse effects Cohort Studies Doxorubicin - analogs & derivatives Humans Oxaliplatin - therapeutic use Polyethylene Glycols Stomach Neoplasms - drug therapy |
title | Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study |
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