Chemotherapy and targeted therapy near the end of life affects aggressiveness of palliative care
The purpose of this study was to explore the difference in quality indicators for chemotherapy or targeted therapy for patients with cancer in their last month of life. A total of 585 patients who had received targeted therapy or palliative chemotherapy (PCT) from April 2007 to December 2018 at the...
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| Veröffentlicht in: | Annals of palliative medicine 2021-03, Vol.10 (3), p.2917-2925 |
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| container_title | Annals of palliative medicine |
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| creator | Zhang, Zhe Chen, Meng-Lei Liu, Ming-Hui Cheng, Wen-Wu |
| description | The purpose of this study was to explore the difference in quality indicators for chemotherapy or targeted therapy for patients with cancer in their last month of life.
A total of 585 patients who had received targeted therapy or palliative chemotherapy (PCT) from April 2007 to December 2018 at the Department of Integrated Therapy of Fudan University Shanghai Cancer Center were included in this retrospective study. The patients' social demographic and clinical data were collected, and variables judged to be independent predictors of PCT or targeted therapy were selected for univariate and multivariate analyses of differences.
Treatment with PCT was independently associated with age (P |
| doi_str_mv | 10.21037/apm-20-1845 |
| format | Article |
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A total of 585 patients who had received targeted therapy or palliative chemotherapy (PCT) from April 2007 to December 2018 at the Department of Integrated Therapy of Fudan University Shanghai Cancer Center were included in this retrospective study. The patients' social demographic and clinical data were collected, and variables judged to be independent predictors of PCT or targeted therapy were selected for univariate and multivariate analyses of differences.
Treatment with PCT was independently associated with age (P<0.001) and performance status (PS) (P<0.001). Treatment with targeted therapy was independently associated with PS (P<0.001). Patients who received continued chemotherapy or cardiopulmonary resuscitation (CPR) within the last month of life were subjected to more intensive treatment in comparison with those who did not know when they were admitted to the intensive care unit (ICU) in the last month of life (P<0.001). Subgroup analysis showed that lung cancer was independently associated with targeted therapy (P<0.001), and admission to the ICU was independently associated with PCT (P<0.001).
In the last month of life, approximately 14.9% of patients with cancer received PCT, which conformed to international recommendations. Lower CPR rates and admission to the ICU were positively correlated with targeted therapy versus those who received chemotherapy at the end of life (EOL).]]></description><identifier>ISSN: 2224-5820</identifier><identifier>EISSN: 2224-5839</identifier><identifier>DOI: 10.21037/apm-20-1845</identifier><identifier>PMID: 33549022</identifier><language>eng</language><publisher>China</publisher><subject>China ; Death ; Humans ; Neoplasms - drug therapy ; Palliative Care ; Retrospective Studies ; Terminal Care</subject><ispartof>Annals of palliative medicine, 2021-03, Vol.10 (3), p.2917-2925</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-d607f1ea044d2eef1a827bde326dcf1b99809fee36e29ff891f2a154d128428e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33549022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Chen, Meng-Lei</creatorcontrib><creatorcontrib>Liu, Ming-Hui</creatorcontrib><creatorcontrib>Cheng, Wen-Wu</creatorcontrib><title>Chemotherapy and targeted therapy near the end of life affects aggressiveness of palliative care</title><title>Annals of palliative medicine</title><addtitle>Ann Palliat Med</addtitle><description><![CDATA[The purpose of this study was to explore the difference in quality indicators for chemotherapy or targeted therapy for patients with cancer in their last month of life.
A total of 585 patients who had received targeted therapy or palliative chemotherapy (PCT) from April 2007 to December 2018 at the Department of Integrated Therapy of Fudan University Shanghai Cancer Center were included in this retrospective study. The patients' social demographic and clinical data were collected, and variables judged to be independent predictors of PCT or targeted therapy were selected for univariate and multivariate analyses of differences.
Treatment with PCT was independently associated with age (P<0.001) and performance status (PS) (P<0.001). Treatment with targeted therapy was independently associated with PS (P<0.001). Patients who received continued chemotherapy or cardiopulmonary resuscitation (CPR) within the last month of life were subjected to more intensive treatment in comparison with those who did not know when they were admitted to the intensive care unit (ICU) in the last month of life (P<0.001). Subgroup analysis showed that lung cancer was independently associated with targeted therapy (P<0.001), and admission to the ICU was independently associated with PCT (P<0.001).
In the last month of life, approximately 14.9% of patients with cancer received PCT, which conformed to international recommendations. Lower CPR rates and admission to the ICU were positively correlated with targeted therapy versus those who received chemotherapy at the end of life (EOL).]]></description><subject>China</subject><subject>Death</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>Palliative Care</subject><subject>Retrospective Studies</subject><subject>Terminal Care</subject><issn>2224-5820</issn><issn>2224-5839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhC0EolXpjTPyAxCw105rH1HEn1SJC5zDNt5tg5I2sgNS356Ulp5mdma0h0-Ia63uQCszv8euzUBl2tn8TIwBwGa5M_785EGNxDSlL6WUBuOsh0sxMia3XgGMxWexpnbbrylit5O4CbLHuKKeBnMMN4Rxf0ga2i3LpmaSyExVnySuVpFSqn9oM8i-7rBpauyHRFYY6UpcMDaJpkediI-nx_fiJVu8Pb8WD4usMuD7LMzUnDWhsjYAEWt0MF8GMjALFeul9055JjIzAs_svGZAndugwVlwZCbi9vC3ituUInHZxbrFuCu1Kv9YlQOrElS5ZzXMbw7z7nvZUjiN_8mYXy5JZiE</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Zhang, Zhe</creator><creator>Chen, Meng-Lei</creator><creator>Liu, Ming-Hui</creator><creator>Cheng, Wen-Wu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210301</creationdate><title>Chemotherapy and targeted therapy near the end of life affects aggressiveness of palliative care</title><author>Zhang, Zhe ; Chen, Meng-Lei ; Liu, Ming-Hui ; Cheng, Wen-Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-d607f1ea044d2eef1a827bde326dcf1b99809fee36e29ff891f2a154d128428e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>China</topic><topic>Death</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>Palliative Care</topic><topic>Retrospective Studies</topic><topic>Terminal Care</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Chen, Meng-Lei</creatorcontrib><creatorcontrib>Liu, Ming-Hui</creatorcontrib><creatorcontrib>Cheng, Wen-Wu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of palliative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhe</au><au>Chen, Meng-Lei</au><au>Liu, Ming-Hui</au><au>Cheng, Wen-Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotherapy and targeted therapy near the end of life affects aggressiveness of palliative care</atitle><jtitle>Annals of palliative medicine</jtitle><addtitle>Ann Palliat Med</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>10</volume><issue>3</issue><spage>2917</spage><epage>2925</epage><pages>2917-2925</pages><issn>2224-5820</issn><eissn>2224-5839</eissn><abstract><![CDATA[The purpose of this study was to explore the difference in quality indicators for chemotherapy or targeted therapy for patients with cancer in their last month of life.
A total of 585 patients who had received targeted therapy or palliative chemotherapy (PCT) from April 2007 to December 2018 at the Department of Integrated Therapy of Fudan University Shanghai Cancer Center were included in this retrospective study. The patients' social demographic and clinical data were collected, and variables judged to be independent predictors of PCT or targeted therapy were selected for univariate and multivariate analyses of differences.
Treatment with PCT was independently associated with age (P<0.001) and performance status (PS) (P<0.001). Treatment with targeted therapy was independently associated with PS (P<0.001). Patients who received continued chemotherapy or cardiopulmonary resuscitation (CPR) within the last month of life were subjected to more intensive treatment in comparison with those who did not know when they were admitted to the intensive care unit (ICU) in the last month of life (P<0.001). Subgroup analysis showed that lung cancer was independently associated with targeted therapy (P<0.001), and admission to the ICU was independently associated with PCT (P<0.001).
In the last month of life, approximately 14.9% of patients with cancer received PCT, which conformed to international recommendations. Lower CPR rates and admission to the ICU were positively correlated with targeted therapy versus those who received chemotherapy at the end of life (EOL).]]></abstract><cop>China</cop><pmid>33549022</pmid><doi>10.21037/apm-20-1845</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Annals of palliative medicine, 2021-03, Vol.10 (3), p.2917-2925 |
| issn | 2224-5820 2224-5839 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | China Death Humans Neoplasms - drug therapy Palliative Care Retrospective Studies Terminal Care |
| title | Chemotherapy and targeted therapy near the end of life affects aggressiveness of palliative care |
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