Sensitive Voltammetric Determination of Paracetamol on Poly(4-Aminobenzene Sulfonic Acid) Modified Glassy Carbon Electrode

A poly (4-aminobenzene sulfonic acid) (4-ABSA) modified glassy carbon electrode (GCE) was prepared for the quantitative determination of paracetamol (PCT). The 4-ABSA-modified GCE was prepared by electrochemical polymerization method in phosphate buffer solution (PBS) (pH 7.0). The polymer film-modified electrode has high catalytic ability for electrooxidation of PCT, which appeared at pH range of 5-8 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The best results for the determination of PCT were obtained by DPV in PBS (pH 7.00). Calibration curve was obtained in the PCT concentration range of 6x10-7 to 9x10-6 mol L-1 by DPV. Limit of detection (LOD) and quantification (LOQ) were found as 9.33x10-8 mol L-1 and 3.10x10-7 mol L-1, respectively. The results of experiments indicated that modified electrode have good stability, sensitivity and reproducibility for at least one month if stored dry in air.