Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure
Noninvasive ventilation (NIV) has changed the prognosis of patients with chronic obstructive pulmonary disease (COPD) suffering from hypercapnic exacerbations. The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD exacerbation treate...
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| Veröffentlicht in: | Polskie archiwum medycyny wewne̦trznej 2014-01, Vol.124 (10), p.525-531 |
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| container_title | Polskie archiwum medycyny wewne̦trznej |
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| creator | Nicolini, Antonello Ferrera, Lorenzo Santo, Mario Ferrari-Bravo, Maura Del Forno, Manuela Sclifò, Francesca |
| description | Noninvasive ventilation (NIV) has changed the prognosis of patients with chronic obstructive pulmonary disease (COPD) suffering from hypercapnic exacerbations.
The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD exacerbation treated with NIV and to estimate factors related to either success or failure of NIV in a real-life setting.
In a multicenter prospective study conducted over a period of 10 years (2002-2012), we assessed 1809 patients with COPD with hypercapnic exacerbation on admission who were treated with NIV. The primary outcomes were the intubation rate and hospital mortality.
In all patients, NIV was conducted by experienced specialists. The intubation rate was 6.6% and the mortality rate was 5.3%. The severity of exacerbations, defined by pH and the Simplified Acute Physiology Score (SAPS II) on admission, worsened during the study period. The presence of comorbidities, SAPS II, pH, the ratio of oxygen arterial pressure to oxygen inspiratory fraction on admission, and, above all, no increase in pH after 1 hour of NIV were closely related to hospital mortality.
Team expertise in NIV and identification of the risk factors for NIV failure may allow to treat patients with more severe hypercapnic exacerbations of COPD during and improve treatment success rates. |
| doi_str_mv | 10.20452/pamw.2460 |
| format | Article |
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The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD exacerbation treated with NIV and to estimate factors related to either success or failure of NIV in a real-life setting.
In a multicenter prospective study conducted over a period of 10 years (2002-2012), we assessed 1809 patients with COPD with hypercapnic exacerbation on admission who were treated with NIV. The primary outcomes were the intubation rate and hospital mortality.
In all patients, NIV was conducted by experienced specialists. The intubation rate was 6.6% and the mortality rate was 5.3%. The severity of exacerbations, defined by pH and the Simplified Acute Physiology Score (SAPS II) on admission, worsened during the study period. The presence of comorbidities, SAPS II, pH, the ratio of oxygen arterial pressure to oxygen inspiratory fraction on admission, and, above all, no increase in pH after 1 hour of NIV were closely related to hospital mortality.
Team expertise in NIV and identification of the risk factors for NIV failure may allow to treat patients with more severe hypercapnic exacerbations of COPD during and improve treatment success rates.</description><identifier>ISSN: 1897-9483</identifier><identifier>EISSN: 1897-9483</identifier><identifier>DOI: 10.20452/pamw.2460</identifier><identifier>PMID: 25188226</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Aged ; Female ; Humans ; Hypercapnia - etiology ; Hypercapnia - mortality ; Male ; Middle Aged ; Monitoring, Physiologic - methods ; Monitoring, Physiologic - statistics & numerical data ; Noninvasive Ventilation - adverse effects ; Noninvasive Ventilation - methods ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - therapy ; Risk Factors ; Survival Rate</subject><ispartof>Polskie archiwum medycyny wewne̦trznej, 2014-01, Vol.124 (10), p.525-531</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c290t-ada9df6fdf9d8d575b5f5a52b431395774e74815666cb35e0f7533a07c66236f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25188226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicolini, Antonello</creatorcontrib><creatorcontrib>Ferrera, Lorenzo</creatorcontrib><creatorcontrib>Santo, Mario</creatorcontrib><creatorcontrib>Ferrari-Bravo, Maura</creatorcontrib><creatorcontrib>Del Forno, Manuela</creatorcontrib><creatorcontrib>Sclifò, Francesca</creatorcontrib><title>Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure</title><title>Polskie archiwum medycyny wewne̦trznej</title><addtitle>Pol Arch Med Wewn</addtitle><description>Noninvasive ventilation (NIV) has changed the prognosis of patients with chronic obstructive pulmonary disease (COPD) suffering from hypercapnic exacerbations.
The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD exacerbation treated with NIV and to estimate factors related to either success or failure of NIV in a real-life setting.
In a multicenter prospective study conducted over a period of 10 years (2002-2012), we assessed 1809 patients with COPD with hypercapnic exacerbation on admission who were treated with NIV. The primary outcomes were the intubation rate and hospital mortality.
In all patients, NIV was conducted by experienced specialists. The intubation rate was 6.6% and the mortality rate was 5.3%. The severity of exacerbations, defined by pH and the Simplified Acute Physiology Score (SAPS II) on admission, worsened during the study period. The presence of comorbidities, SAPS II, pH, the ratio of oxygen arterial pressure to oxygen inspiratory fraction on admission, and, above all, no increase in pH after 1 hour of NIV were closely related to hospital mortality.
Team expertise in NIV and identification of the risk factors for NIV failure may allow to treat patients with more severe hypercapnic exacerbations of COPD during and improve treatment success rates.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Hypercapnia - etiology</subject><subject>Hypercapnia - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Monitoring, Physiologic - statistics & numerical data</subject><subject>Noninvasive Ventilation - adverse effects</subject><subject>Noninvasive Ventilation - methods</subject><subject>Prospective Studies</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><issn>1897-9483</issn><issn>1897-9483</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1OwzAQhS0EoqWw4QDIa6QUx47thB2qyo9UwQbWkWOPVaMkjuyk0GNwYxoKiA2rGc28eW_0IXSekjklGadXnWre5jQT5ABN07yQSZHl7PBPP0EnMb4SIgqWy2M0oTzNc0rFFH08-ta1GxXdBvAG2t7Vqne-xdYHvN52ELTqWqcxvCsNodovvcV6Hfw491Xsw6D78b4b6sa3KmyxcRFUhGtsle59iDjAzhcM7j1u_0tUrh4CnKIjq-oIZ991hl5ul8-L-2T1dPewuFklmhakT5RRhbHCGluY3HDJK2654rTKWMoKLmUGMstTLoTQFeNArOSMKSK1EJQJy2bocu-rg48xgC274Jrd82VKyi-u5ci1HLnuxBd7cTdUDZhf6Q9I9gn_l3kx</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Nicolini, Antonello</creator><creator>Ferrera, Lorenzo</creator><creator>Santo, Mario</creator><creator>Ferrari-Bravo, Maura</creator><creator>Del Forno, Manuela</creator><creator>Sclifò, Francesca</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140101</creationdate><title>Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure</title><author>Nicolini, Antonello ; Ferrera, Lorenzo ; Santo, Mario ; Ferrari-Bravo, Maura ; Del Forno, Manuela ; Sclifò, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-ada9df6fdf9d8d575b5f5a52b431395774e74815666cb35e0f7533a07c66236f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Hypercapnia - etiology</topic><topic>Hypercapnia - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic - methods</topic><topic>Monitoring, Physiologic - statistics & numerical data</topic><topic>Noninvasive Ventilation - adverse effects</topic><topic>Noninvasive Ventilation - methods</topic><topic>Prospective Studies</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicolini, Antonello</creatorcontrib><creatorcontrib>Ferrera, Lorenzo</creatorcontrib><creatorcontrib>Santo, Mario</creatorcontrib><creatorcontrib>Ferrari-Bravo, Maura</creatorcontrib><creatorcontrib>Del Forno, Manuela</creatorcontrib><creatorcontrib>Sclifò, Francesca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Polskie archiwum medycyny wewne̦trznej</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicolini, Antonello</au><au>Ferrera, Lorenzo</au><au>Santo, Mario</au><au>Ferrari-Bravo, Maura</au><au>Del Forno, Manuela</au><au>Sclifò, Francesca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure</atitle><jtitle>Polskie archiwum medycyny wewne̦trznej</jtitle><addtitle>Pol Arch Med Wewn</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>124</volume><issue>10</issue><spage>525</spage><epage>531</epage><pages>525-531</pages><issn>1897-9483</issn><eissn>1897-9483</eissn><abstract>Noninvasive ventilation (NIV) has changed the prognosis of patients with chronic obstructive pulmonary disease (COPD) suffering from hypercapnic exacerbations.
The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD exacerbation treated with NIV and to estimate factors related to either success or failure of NIV in a real-life setting.
In a multicenter prospective study conducted over a period of 10 years (2002-2012), we assessed 1809 patients with COPD with hypercapnic exacerbation on admission who were treated with NIV. The primary outcomes were the intubation rate and hospital mortality.
In all patients, NIV was conducted by experienced specialists. The intubation rate was 6.6% and the mortality rate was 5.3%. The severity of exacerbations, defined by pH and the Simplified Acute Physiology Score (SAPS II) on admission, worsened during the study period. The presence of comorbidities, SAPS II, pH, the ratio of oxygen arterial pressure to oxygen inspiratory fraction on admission, and, above all, no increase in pH after 1 hour of NIV were closely related to hospital mortality.
Team expertise in NIV and identification of the risk factors for NIV failure may allow to treat patients with more severe hypercapnic exacerbations of COPD during and improve treatment success rates.</abstract><cop>Poland</cop><pmid>25188226</pmid><doi>10.20452/pamw.2460</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1897-9483 |
| ispartof | Polskie archiwum medycyny wewne̦trznej, 2014-01, Vol.124 (10), p.525-531 |
| issn | 1897-9483 1897-9483 |
| language | eng |
| recordid | cdi_crossref_primary_10_20452_pamw_2460 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Female Humans Hypercapnia - etiology Hypercapnia - mortality Male Middle Aged Monitoring, Physiologic - methods Monitoring, Physiologic - statistics & numerical data Noninvasive Ventilation - adverse effects Noninvasive Ventilation - methods Prospective Studies Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - therapy Risk Factors Survival Rate |
| title | Noninvasive ventilation for hypercapnic exacerbation of chronic obstructive pulmonary disease: factors related to noninvasive ventilation failure |
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