Study on the effectiveness of a multi-toxin immunoaffinity clean-up for reliable cost-effective HPLC-FLD analysis of mycotoxins in corn-based foods

Study on the effectiveness of a multi-toxin immunoaffinity clean-up for reliable cost-effective HPLC-FLD analysis of mycotoxins in corn-based foods

A different, reliable, and cost-effective strategy for the analysis of aflatoxins, ochratoxin A, and zearalenone in corn-based foods was proposed, including one multi-toxin immunoaffinity column (IAC) sample preparation and three different high-performance liquid chromatography fluorescence detectio...

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Veröffentlicht in:Macedonian Journal of Chemistry and Chemical Engineering 2022-01, Vol.41 (1), p.77-88
Hauptverfasser: Stojanovska Dimzoska, Biljana, Hajrulai Musliu, Zehra, Uzunov, Risto, Angeleska, Aleksandra, Blagoevska, Katerina, Crceva Nikolovska, Radmila, Ilievska, Gordana, Dimitrieska Stojkovic, Elizabeta
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container_issue 1
container_start_page 77
container_title Macedonian Journal of Chemistry and Chemical Engineering
container_volume 41
creator Stojanovska Dimzoska, Biljana
Hajrulai Musliu, Zehra
Uzunov, Risto
Angeleska, Aleksandra
Blagoevska, Katerina
Crceva Nikolovska, Radmila
Ilievska, Gordana
Dimitrieska Stojkovic, Elizabeta
description A different, reliable, and cost-effective strategy for the analysis of aflatoxins, ochratoxin A, and zearalenone in corn-based foods was proposed, including one multi-toxin immunoaffinity column (IAC) sample preparation and three different high-performance liquid chromatography fluorescence detection methods. The analytical procedures were tested and verified, keeping in mind their occurrence at trace levels in corn-based foods. With the validation of the proposed multi-toxin IAC methodology and comparison of the performance characteristics with methods using a single-toxin IAC, we confirmed the reliability of the multi-toxin IAC procedure versus the single-toxin IAC. The methods were validated by revealing satisfactory performance characteristics; for example, the obtained values of limit of detection were significantly lower than the maximum limits for all mycotoxins of concern. In addition, the recovery values were between 70.9 % and 106.1 % for all mycotoxins of interest, with precision values lower than 10.5 %.  
doi_str_mv 10.20450/mjcce.2022.2422
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title Study on the effectiveness of a multi-toxin immunoaffinity clean-up for reliable cost-effective HPLC-FLD analysis of mycotoxins in corn-based foods
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