Short‐Term Side Effects of 0.2% Alcohol‐Free Chlorhexidine Mouthrinse Used as an Adjunct to Non‐Surgical Periodontal Treatment: A Double‐Blind Clinical Study
Background: The aims of this clinical study were to evaluate the short‐term subjective (by means of questionnaire) and objective (by means of clinical examination) side effects of 0.2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non‐surgical periodontal treatment and to eluc...
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| Veröffentlicht in: | Journal of periodontology (1970) 2006-03, Vol.77 (3), p.370-384 |
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| creator | Gürgan, Cem A. Zaim, Eylem Bakirsoy, Işıl Soykan, Emel |
| description | Background: The aims of this clinical study were to evaluate the short‐term subjective (by means of questionnaire) and objective (by means of clinical examination) side effects of 0.2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non‐surgical periodontal treatment and to elucidate the relationship between the subjective and objective evaluations.
Methods: This was a randomized, double‐blind, placebo‐controlled clinical trial with two groups: 1) the test group, rinsing with the test product (0.2% CHX without alcohol) twice per day for 1 week, and 2) the control (placebo) group, rinsing with a placebo solution twice per day for 1 week. Following the start of rinsing, patients were subjectively and objectively evaluated for the presence and severity of side effects (pain, burning sensation, pruritus, dryness of mouth, taste disturbance, mucosal irritations, and discoloration of tooth and tongue surfaces) at days 1, 3, and 7 of the rinsing period. The presence of subjective and objective side effects of the groups was compared via use of χ2 and Fisher exact tests. Analysis of the subjective and objective side effects within the evaluation periods was done by McNemar test. Spearman correlation analysis was used to assess the relationships between the subjective and objective side effects.
Results: None of the patients in either group complained of dryness of the mouth. The most commonly reported side effect was the change in color of the labial and buccal mucosa, particularly of the gingiva, after day 3 of rinsing. There were significant (r = 0.308 to 0.835; P |
| doi_str_mv | 10.1902/jop.2006.050141 |
| format | Article |
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Methods: This was a randomized, double‐blind, placebo‐controlled clinical trial with two groups: 1) the test group, rinsing with the test product (0.2% CHX without alcohol) twice per day for 1 week, and 2) the control (placebo) group, rinsing with a placebo solution twice per day for 1 week. Following the start of rinsing, patients were subjectively and objectively evaluated for the presence and severity of side effects (pain, burning sensation, pruritus, dryness of mouth, taste disturbance, mucosal irritations, and discoloration of tooth and tongue surfaces) at days 1, 3, and 7 of the rinsing period. The presence of subjective and objective side effects of the groups was compared via use of χ2 and Fisher exact tests. Analysis of the subjective and objective side effects within the evaluation periods was done by McNemar test. Spearman correlation analysis was used to assess the relationships between the subjective and objective side effects.
Results: None of the patients in either group complained of dryness of the mouth. The most commonly reported side effect was the change in color of the labial and buccal mucosa, particularly of the gingiva, after day 3 of rinsing. There were significant (r = 0.308 to 0.835; P <0.05) correlations between the discolorations of tongue and tooth surfaces reported by the patients and clinically detected at all evaluation periods. There was a significant and positive relationship between the subjective side effects and the soft tissue irritations when the duration of rinsing increased.
Conclusion: Within the limits of this clinical evaluation, rinsing with 0.2% alcohol‐free CHX for 1 week caused more irritation to oral mucosa, greater burning sensation, and increased altered taste perception compared to the placebo rinse.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2006.050141</identifier><identifier>PMID: 16512751</identifier><language>eng</language><publisher>United States: American Academy of Periodontology</publisher><subject>Adolescent ; Adult ; Anti-Infective Agents, Local - adverse effects ; Chi-Square Distribution ; Chlorhexidine ; Chlorhexidine - adverse effects ; Chlorhexidine - analogs & derivatives ; Chlorhexidine - chemistry ; Double-Blind Method ; Ethanol ; Female ; Gingivitis - drug therapy ; Humans ; Male ; Middle Aged ; Mouth Mucosa - drug effects ; Mouthwashes - adverse effects ; Pain - chemically induced ; Periodontal Index ; Pruritus - chemically induced ; side effects ; Statistics, Nonparametric ; Surveys and Questionnaires ; Taste - drug effects</subject><ispartof>Journal of periodontology (1970), 2006-03, Vol.77 (3), p.370-384</ispartof><rights>2006 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4480-41e44276b30aaf582077106cc795b70331281ca31a0bdaf17770e10ddefaa7bb3</citedby><cites>FETCH-LOGICAL-c4480-41e44276b30aaf582077106cc795b70331281ca31a0bdaf17770e10ddefaa7bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2006.050141$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2006.050141$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16512751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gürgan, Cem A.</creatorcontrib><creatorcontrib>Zaim, Eylem</creatorcontrib><creatorcontrib>Bakirsoy, Işıl</creatorcontrib><creatorcontrib>Soykan, Emel</creatorcontrib><title>Short‐Term Side Effects of 0.2% Alcohol‐Free Chlorhexidine Mouthrinse Used as an Adjunct to Non‐Surgical Periodontal Treatment: A Double‐Blind Clinical Study</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: The aims of this clinical study were to evaluate the short‐term subjective (by means of questionnaire) and objective (by means of clinical examination) side effects of 0.2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non‐surgical periodontal treatment and to elucidate the relationship between the subjective and objective evaluations.
Methods: This was a randomized, double‐blind, placebo‐controlled clinical trial with two groups: 1) the test group, rinsing with the test product (0.2% CHX without alcohol) twice per day for 1 week, and 2) the control (placebo) group, rinsing with a placebo solution twice per day for 1 week. Following the start of rinsing, patients were subjectively and objectively evaluated for the presence and severity of side effects (pain, burning sensation, pruritus, dryness of mouth, taste disturbance, mucosal irritations, and discoloration of tooth and tongue surfaces) at days 1, 3, and 7 of the rinsing period. The presence of subjective and objective side effects of the groups was compared via use of χ2 and Fisher exact tests. Analysis of the subjective and objective side effects within the evaluation periods was done by McNemar test. Spearman correlation analysis was used to assess the relationships between the subjective and objective side effects.
Results: None of the patients in either group complained of dryness of the mouth. The most commonly reported side effect was the change in color of the labial and buccal mucosa, particularly of the gingiva, after day 3 of rinsing. There were significant (r = 0.308 to 0.835; P <0.05) correlations between the discolorations of tongue and tooth surfaces reported by the patients and clinically detected at all evaluation periods. There was a significant and positive relationship between the subjective side effects and the soft tissue irritations when the duration of rinsing increased.
Conclusion: Within the limits of this clinical evaluation, rinsing with 0.2% alcohol‐free CHX for 1 week caused more irritation to oral mucosa, greater burning sensation, and increased altered taste perception compared to the placebo rinse.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Infective Agents, Local - adverse effects</subject><subject>Chi-Square Distribution</subject><subject>Chlorhexidine</subject><subject>Chlorhexidine - adverse effects</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Chlorhexidine - chemistry</subject><subject>Double-Blind Method</subject><subject>Ethanol</subject><subject>Female</subject><subject>Gingivitis - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouthwashes - adverse effects</subject><subject>Pain - chemically induced</subject><subject>Periodontal Index</subject><subject>Pruritus - chemically induced</subject><subject>side effects</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Taste - drug effects</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtuEzEUhi1ERUNhzQ55w3LS48uME3YhpKWoQEXS9chjn2EcTcaR7RFk10fgJfpiPAluU4klm3ORvv_o6CPkDYMpmwM_3_r9lANUUyiBSfaMTNhcikJUCp6TCQDnhZBzfkpexrjNK5MCXpBTVpWMq5JNyP268yH9ufu9wbCja2eRrtoWTYrUtxSm_B1d9MZ3vs_MRUCky673ocNfzroB6Rc_pi64ISK9jWipjlQPdGG342ASTZ5-9UNOrsfwwxnd0xsMzls_pDxvAuq0wyG9pwv60Y9Njxn90LvB0mWuj4F1Gu3hFTlpdR_x9VM_I7cXq83yU3H97fJqubgujJQzKCRDKbmqGgFat-WMg1IMKmPUvGwUCMH4jBktmIbG6pYppQAZWIut1qppxBk5P941wccYsK33we10ONQM6gfhdRZePwivj8Jz4u0xsR-bHdp__JPhDJRH4Kfr8fC_e_Xnm9V3EPnXv-m9kRo</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Gürgan, Cem A.</creator><creator>Zaim, Eylem</creator><creator>Bakirsoy, Işıl</creator><creator>Soykan, Emel</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200603</creationdate><title>Short‐Term Side Effects of 0.2% Alcohol‐Free Chlorhexidine Mouthrinse Used as an Adjunct to Non‐Surgical Periodontal Treatment: A Double‐Blind Clinical Study</title><author>Gürgan, Cem A. ; Zaim, Eylem ; Bakirsoy, Işıl ; Soykan, Emel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4480-41e44276b30aaf582077106cc795b70331281ca31a0bdaf17770e10ddefaa7bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Infective Agents, Local - adverse effects</topic><topic>Chi-Square Distribution</topic><topic>Chlorhexidine</topic><topic>Chlorhexidine - adverse effects</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Chlorhexidine - chemistry</topic><topic>Double-Blind Method</topic><topic>Ethanol</topic><topic>Female</topic><topic>Gingivitis - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - drug effects</topic><topic>Mouthwashes - adverse effects</topic><topic>Pain - chemically induced</topic><topic>Periodontal Index</topic><topic>Pruritus - chemically induced</topic><topic>side effects</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Taste - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gürgan, Cem A.</creatorcontrib><creatorcontrib>Zaim, Eylem</creatorcontrib><creatorcontrib>Bakirsoy, Işıl</creatorcontrib><creatorcontrib>Soykan, Emel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gürgan, Cem A.</au><au>Zaim, Eylem</au><au>Bakirsoy, Işıl</au><au>Soykan, Emel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short‐Term Side Effects of 0.2% Alcohol‐Free Chlorhexidine Mouthrinse Used as an Adjunct to Non‐Surgical Periodontal Treatment: A Double‐Blind Clinical Study</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>77</volume><issue>3</issue><spage>370</spage><epage>384</epage><pages>370-384</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: The aims of this clinical study were to evaluate the short‐term subjective (by means of questionnaire) and objective (by means of clinical examination) side effects of 0.2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non‐surgical periodontal treatment and to elucidate the relationship between the subjective and objective evaluations.
Methods: This was a randomized, double‐blind, placebo‐controlled clinical trial with two groups: 1) the test group, rinsing with the test product (0.2% CHX without alcohol) twice per day for 1 week, and 2) the control (placebo) group, rinsing with a placebo solution twice per day for 1 week. Following the start of rinsing, patients were subjectively and objectively evaluated for the presence and severity of side effects (pain, burning sensation, pruritus, dryness of mouth, taste disturbance, mucosal irritations, and discoloration of tooth and tongue surfaces) at days 1, 3, and 7 of the rinsing period. The presence of subjective and objective side effects of the groups was compared via use of χ2 and Fisher exact tests. Analysis of the subjective and objective side effects within the evaluation periods was done by McNemar test. Spearman correlation analysis was used to assess the relationships between the subjective and objective side effects.
Results: None of the patients in either group complained of dryness of the mouth. The most commonly reported side effect was the change in color of the labial and buccal mucosa, particularly of the gingiva, after day 3 of rinsing. There were significant (r = 0.308 to 0.835; P <0.05) correlations between the discolorations of tongue and tooth surfaces reported by the patients and clinically detected at all evaluation periods. There was a significant and positive relationship between the subjective side effects and the soft tissue irritations when the duration of rinsing increased.
Conclusion: Within the limits of this clinical evaluation, rinsing with 0.2% alcohol‐free CHX for 1 week caused more irritation to oral mucosa, greater burning sensation, and increased altered taste perception compared to the placebo rinse.</abstract><cop>United States</cop><pub>American Academy of Periodontology</pub><pmid>16512751</pmid><doi>10.1902/jop.2006.050141</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of periodontology (1970), 2006-03, Vol.77 (3), p.370-384 |
| issn | 0022-3492 1943-3670 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Anti-Infective Agents, Local - adverse effects Chi-Square Distribution Chlorhexidine Chlorhexidine - adverse effects Chlorhexidine - analogs & derivatives Chlorhexidine - chemistry Double-Blind Method Ethanol Female Gingivitis - drug therapy Humans Male Middle Aged Mouth Mucosa - drug effects Mouthwashes - adverse effects Pain - chemically induced Periodontal Index Pruritus - chemically induced side effects Statistics, Nonparametric Surveys and Questionnaires Taste - drug effects |
| title | Short‐Term Side Effects of 0.2% Alcohol‐Free Chlorhexidine Mouthrinse Used as an Adjunct to Non‐Surgical Periodontal Treatment: A Double‐Blind Clinical Study |
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