Adverse effects of Oxytetracycline hydrochloride, Florfenicol, Sulphadimethoxine and Ormetoprim in Tilapia (Oreochromis niloticus) at Therapeutic dose and Maximum Residual Limit (MRL) level

Background: In Aquaculture sector, antibiotics are commonly used for treating many diseases (because of intensification) and to promote fish growth. Since, many antibiotics have been used improperly, their deposits in aquatic environment are able to cause toxic effects in fish. However, studies based on toxicity of antibiotics in fish is very low. This study explains about the adverse/toxic effects of three commonly used antibiotics (Oxytetracycline hydrochloride, florfenicol, Sulphadimethoxine and ormetoprim) in fish. Inspite of their positive effects, antibiotics are able to cause damage to metabolic system and organs. Accordingly, there are serious worries about the harmfulness of antibiotics in fish and further exploration and methodologies are expected to forestall them in various districts of the world. Methods: The study discusses whether the presence of antibiotics alter the normal functioning of organs in Tilapia (Oreochromis niloticus). Hematology, biochemical parameters and histopathological analysis have been carried out to determine the effect of antibiotics. Result: The results revealed that the presence of antibiotics elevates toxic and biochemical lesions in Tilapia (Oreochromis niloticus). This study will help in getting information related to antibiotics effect in fish.