Characterization, Antioxidant and Anticholinesterase Activity of Compounds Isolated from Alkaloid Extracts of Citrus aurantifolia Root Bark

Characterization, Antioxidant and Anticholinesterase Activity of Compounds Isolated from Alkaloid Extracts of Citrus aurantifolia Root Bark

Xanthyletin (1), edulinin (2), 1-methyl-2-[(E)-(prop-1-enyl)]quinolin-4-one (3), 1,2-dimethylquinolin-4-one (4), lonchocarpol A (5), grandisinin (6), citracridone-I (7) and 5-hydroxynoracronycin (8) were isolated from alkaloid extracts of the root bark of Citrus aurantifolia. Their structures were c...

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Veröffentlicht in:Journal of the Turkish Chemical Society, Section A, Chemistry Section A, Chemistry, 2024-08, Vol.11 (3), p.1227-1236
Hauptverfasser: Zıale, Djélé Alette Edwige, Adou, Demel Axel, N'gaman-kouassı, Kohue Christelle Chantal, Deschamp, Julia, Bouchemal, Nadia, Palama, Tony Lionel, Lecouvey, Marc, Mamyrbekova-békro, Janat Akhanovna, Bekro, Yves-alain
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container_issue 3
container_start_page 1227
container_title Journal of the Turkish Chemical Society, Section A, Chemistry
container_volume 11
creator Zıale, Djélé Alette Edwige
Adou, Demel Axel
N'gaman-kouassı, Kohue Christelle Chantal
Deschamp, Julia
Bouchemal, Nadia
Palama, Tony Lionel
Lecouvey, Marc
Mamyrbekova-békro, Janat Akhanovna
Bekro, Yves-alain
description Xanthyletin (1), edulinin (2), 1-methyl-2-[(E)-(prop-1-enyl)]quinolin-4-one (3), 1,2-dimethylquinolin-4-one (4), lonchocarpol A (5), grandisinin (6), citracridone-I (7) and 5-hydroxynoracronycin (8) were isolated from alkaloid extracts of the root bark of Citrus aurantifolia. Their structures were characterized using spectral data (NMR, HRMS, and IR). Furthermore, compounds 2, 3, 4, and 6 known in the literature have been isolated for the first time in Citrus aurantifolia. However, compounds 1, 5, 7 and 8 are already known from the plant studied. The concentration required to reduce 50% of free radicals (RC50) was carried out. Compounds 3 (RC50= 185.836 µmol/L) and 4 (RC50= 218.277 µmol/L) compared with vitamin C (RC50= 17.033 µmol/L) showed antioxidant efficacy. The highest anticholinesterase activity was observed for compound 6 at 21.129 µM followed by compounds 3 and 4 at 251.130, 287.208 µM, respectively.
doi_str_mv 10.18596/jotcsa.1395690
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title Characterization, Antioxidant and Anticholinesterase Activity of Compounds Isolated from Alkaloid Extracts of Citrus aurantifolia Root Bark
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