Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil
The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (...
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| Veröffentlicht in: | Acta biochimica Polonica 2020-03, Vol.67 (1), p.53 |
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| creator | Djaber, Nesrine Ounaceur, Lynda Sabrina Moubine, Baya Nouha Khaldi, Taha Rouag, Mereim Berrouague, Salma Amara, Hichem Taibi, Faiza Boumendjel, Mahieddine Boumendjel, Amel Messarah, Mahfoud |
| description | The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO. |
| doi_str_mv | 10.18388/abp.2020_2898 |
| format | Article |
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Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. 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The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Biomarkers - blood</subject><subject>Flax - chemistry</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - toxicity</subject><subject>Glyphosate</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Linseed Oil - pharmacology</subject><subject>Linseed Oil - therapeutic use</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Oxidative Stress - drug effects</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Rats</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKxDAUhoMozji6dSl5gY7JSTpN3Yl4gwFBFGZXcus02jalaYV5CZ_Z2NHZnMP5L2fxIXRJyZIKJsS1VN0SCJACRC6O0JxmjCc05ZtjNCeE0CSFbDNDZyF8EAKM5vwUzRhQkfGczNH3qx9bM3aJi1Nbg5XzurKN07LGsjW4cmHwnRwqX_vtpOpKtlsbsGvxUFlcuy_bT9FPZ1q7w77EvRzCzeTKxtbOxzumsC1Lq4fwm1i7dmzwGNwQrRBcEy_v6nN0Uso62Iu_vUDvD_dvd0_J-uXx-e52nWiAdEgk5zmDFcBKSAvSlIKYLMuAGi1IllIlQOclBW0sRJ1JwxVnygiZplZxxRZouf-rex9Cb8ui610j-11BSTGBLSLY4gA2Fq72hW5UjTWH-D9J9gOFhHgH</recordid><startdate>20200318</startdate><enddate>20200318</enddate><creator>Djaber, Nesrine</creator><creator>Ounaceur, Lynda Sabrina</creator><creator>Moubine, Baya Nouha</creator><creator>Khaldi, Taha</creator><creator>Rouag, Mereim</creator><creator>Berrouague, Salma</creator><creator>Amara, Hichem</creator><creator>Taibi, Faiza</creator><creator>Boumendjel, Mahieddine</creator><creator>Boumendjel, Amel</creator><creator>Messarah, Mahfoud</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-4278-2317</orcidid><orcidid>https://orcid.org/0000-0002-3163-6058</orcidid><orcidid>https://orcid.org/0000-0002-1455-566X</orcidid><orcidid>https://orcid.org/0000-0002-0928-0542</orcidid></search><sort><creationdate>20200318</creationdate><title>Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil</title><author>Djaber, Nesrine ; Ounaceur, Lynda Sabrina ; Moubine, Baya Nouha ; Khaldi, Taha ; Rouag, Mereim ; Berrouague, Salma ; Amara, Hichem ; Taibi, Faiza ; Boumendjel, Mahieddine ; Boumendjel, Amel ; Messarah, Mahfoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c225t-a4493262268ae2adf80d77721dc80751b82c9f12cde27773ad4b43bd8a55eb4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Biomarkers - blood</topic><topic>Flax - chemistry</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - toxicity</topic><topic>Glyphosate</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Linseed Oil - pharmacology</topic><topic>Linseed Oil - therapeutic use</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Oxidative Stress - drug effects</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Djaber, Nesrine</creatorcontrib><creatorcontrib>Ounaceur, Lynda Sabrina</creatorcontrib><creatorcontrib>Moubine, Baya Nouha</creatorcontrib><creatorcontrib>Khaldi, Taha</creatorcontrib><creatorcontrib>Rouag, Mereim</creatorcontrib><creatorcontrib>Berrouague, Salma</creatorcontrib><creatorcontrib>Amara, Hichem</creatorcontrib><creatorcontrib>Taibi, Faiza</creatorcontrib><creatorcontrib>Boumendjel, Mahieddine</creatorcontrib><creatorcontrib>Boumendjel, Amel</creatorcontrib><creatorcontrib>Messarah, Mahfoud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta biochimica Polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djaber, Nesrine</au><au>Ounaceur, Lynda Sabrina</au><au>Moubine, Baya Nouha</au><au>Khaldi, Taha</au><au>Rouag, Mereim</au><au>Berrouague, Salma</au><au>Amara, Hichem</au><au>Taibi, Faiza</au><au>Boumendjel, Mahieddine</au><au>Boumendjel, Amel</au><au>Messarah, Mahfoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil</atitle><jtitle>Acta biochimica Polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2020-03-18</date><risdate>2020</risdate><volume>67</volume><issue>1</issue><spage>53</spage><pages>53-</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antioxidants - pharmacology Biomarkers - blood Flax - chemistry Glycine - analogs & derivatives Glycine - toxicity Glyphosate Kidney - drug effects Kidney - pathology Linseed Oil - pharmacology Linseed Oil - therapeutic use Liver - drug effects Liver - pathology Oxidative Stress - drug effects Protective Agents - pharmacology Protective Agents - therapeutic use Rats |
| title | Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil |
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