East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population
Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight of them were with genome-wide significance and two with a border line association. Since these data have not been studied in an independent Han Chinese population, we aimed to inv...
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| Veröffentlicht in: | Acta biochimica Polonica 2019-05, Vol.66 (2), p.159 |
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| creator | Zhang, Sijia Jamaspishvili, Esma Tong, Huixin Chen, Yongjie Zhou, Zhongyu Sun, Lulu Kazakova, Elena Hong, Qiao |
| description | Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight of them were with genome-wide significance and two with a border line association. Since these data have not been studied in an independent Han Chinese population, we aimed to investigate the association of these susceptibility loci with type 2 diabetes in an independent Han Chinese population. We executed a case-control study in 2 000 Chinese by the SNPscan method. Firstly, the repetitive sequences of 10 loci were assessed. Next, we investigated the association of 8 SNPs out of 10 with type 2 diabetes and constructed the GRS of those 8 SNPs. Finally, the relationship of the 8 loci and diabetes-related traits was analyzed. Based on the fact, that highly repetitive sequences were detected in 2 SNPs, we investigated the remaining 8 SNPs. With the exception of four SNPs (CMIP rs16955379, PEPD rs3786897, PSMD6 rs831571, ZFAND3 rs9470794), the other SNPs had the same direction of effect (odds ratio [OR]>1.0) as in the original reports, especially GLIS3 rs7041847 and KCNK16 rs1535500 were significantly associated with type 2 diabetes (rs1535500: p=0.005, OR=1.224, 95% CI 1.062-1.409; rs7041847: p=0.035, OR=1.118, 95% CI 1.070-1.388). The GRS constructed from the 8 SNPs was significantly associated with type 2 diabetes in the Chinese population (p=0.004, OR=1.065, 95% CI: 1.021-1.111). Among the participants with 24≤BMI |
| doi_str_mv | 10.18388/abp.2018_2632 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_18388_abp_2018_2632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31145772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c262t-611dfa31e9434d60b6852da041040421c7f25e3bb5833f3ccaaf6fca9b8999df3</originalsourceid><addsrcrecordid>eNo9kFFLwzAUhYMobk5ffZT8gc7cJG3TxzHmJgx8UdhbSZobFtnakmTK_r3Vqk8X7jnfefgIuQc2ByWUetSmn3MGquaF4BdkCqWQGeRyd0mmjDHIcl7uJuQmxnfGuIBKXpOJAJB5WfIpCSsdE11Er1u6xrY7YvbpLVIdY9d4nXzX0phO9kwtBv-Blh6GP_UtDXgY49TRdO6Rcmq9Npgwfsdpj3QzjC73vsWItO_60wjckiunDxHvfu-MvD2tXpebbPuyfl4utlnDC56yAsA6LQArKaQtmClUzq1mEphkkkNTOp6jMCZXQjjRNFq7wjW6MqqqKuvEjMzH3SZ0MQZ0dR_8UYdzDaz-kVcP8up_eQPwMAL9yRzR_tf_bIkvtnlsRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Zhang, Sijia ; Jamaspishvili, Esma ; Tong, Huixin ; Chen, Yongjie ; Zhou, Zhongyu ; Sun, Lulu ; Kazakova, Elena ; Hong, Qiao</creator><creatorcontrib>Zhang, Sijia ; Jamaspishvili, Esma ; Tong, Huixin ; Chen, Yongjie ; Zhou, Zhongyu ; Sun, Lulu ; Kazakova, Elena ; Hong, Qiao</creatorcontrib><description>Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight of them were with genome-wide significance and two with a border line association. Since these data have not been studied in an independent Han Chinese population, we aimed to investigate the association of these susceptibility loci with type 2 diabetes in an independent Han Chinese population. We executed a case-control study in 2 000 Chinese by the SNPscan method. Firstly, the repetitive sequences of 10 loci were assessed. Next, we investigated the association of 8 SNPs out of 10 with type 2 diabetes and constructed the GRS of those 8 SNPs. Finally, the relationship of the 8 loci and diabetes-related traits was analyzed. Based on the fact, that highly repetitive sequences were detected in 2 SNPs, we investigated the remaining 8 SNPs. With the exception of four SNPs (CMIP rs16955379, PEPD rs3786897, PSMD6 rs831571, ZFAND3 rs9470794), the other SNPs had the same direction of effect (odds ratio [OR]>1.0) as in the original reports, especially GLIS3 rs7041847 and KCNK16 rs1535500 were significantly associated with type 2 diabetes (rs1535500: p=0.005, OR=1.224, 95% CI 1.062-1.409; rs7041847: p=0.035, OR=1.118, 95% CI 1.070-1.388). The GRS constructed from the 8 SNPs was significantly associated with type 2 diabetes in the Chinese population (p=0.004, OR=1.065, 95% CI: 1.021-1.111). Among the participants with 24≤BMI<28 kg/m2 the 8 SNPs were significantly associated with type 2 diabetes (p=0.040, OR=1.079, 95% CI: 1.003-1.160). In quantitative trait analyses, WWOX rs17797882 was associated with decreased HOMA-β and increased level of TG and HDL-Ch, while PEPD rs3786897 and MAEA rs6815464 were associated with decreased fasting plasma glucose, and KCNK16 rs1535500 has shown a significant association with increased T-Ch and PSMD6 rs831571 had a significant association with decreased HDL-Ch. In Conclusion, with high probability the 8 loci identified in the East Asian GWAS meta-analysis are associated with type 2 diabetes in the Han Chinese population.</description><identifier>ISSN: 0001-527X</identifier><identifier>EISSN: 1734-154X</identifier><identifier>DOI: 10.18388/abp.2018_2632</identifier><identifier>PMID: 31145772</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Aged ; Body Mass Index ; Case-Control Studies ; China ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Genetic Loci ; Genome-Wide Association Study ; Genotype ; Humans ; Insulin Resistance ; Logistic Models ; Male ; Middle Aged ; Obesity - complications ; Polymorphism, Single Nucleotide ; Repetitive Sequences, Nucleic Acid - genetics ; Risk ; Young Adult</subject><ispartof>Acta biochimica Polonica, 2019-05, Vol.66 (2), p.159</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c262t-611dfa31e9434d60b6852da041040421c7f25e3bb5833f3ccaaf6fca9b8999df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31145772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Sijia</creatorcontrib><creatorcontrib>Jamaspishvili, Esma</creatorcontrib><creatorcontrib>Tong, Huixin</creatorcontrib><creatorcontrib>Chen, Yongjie</creatorcontrib><creatorcontrib>Zhou, Zhongyu</creatorcontrib><creatorcontrib>Sun, Lulu</creatorcontrib><creatorcontrib>Kazakova, Elena</creatorcontrib><creatorcontrib>Hong, Qiao</creatorcontrib><title>East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population</title><title>Acta biochimica Polonica</title><addtitle>Acta Biochim Pol</addtitle><description>Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight of them were with genome-wide significance and two with a border line association. Since these data have not been studied in an independent Han Chinese population, we aimed to investigate the association of these susceptibility loci with type 2 diabetes in an independent Han Chinese population. We executed a case-control study in 2 000 Chinese by the SNPscan method. Firstly, the repetitive sequences of 10 loci were assessed. Next, we investigated the association of 8 SNPs out of 10 with type 2 diabetes and constructed the GRS of those 8 SNPs. Finally, the relationship of the 8 loci and diabetes-related traits was analyzed. Based on the fact, that highly repetitive sequences were detected in 2 SNPs, we investigated the remaining 8 SNPs. With the exception of four SNPs (CMIP rs16955379, PEPD rs3786897, PSMD6 rs831571, ZFAND3 rs9470794), the other SNPs had the same direction of effect (odds ratio [OR]>1.0) as in the original reports, especially GLIS3 rs7041847 and KCNK16 rs1535500 were significantly associated with type 2 diabetes (rs1535500: p=0.005, OR=1.224, 95% CI 1.062-1.409; rs7041847: p=0.035, OR=1.118, 95% CI 1.070-1.388). The GRS constructed from the 8 SNPs was significantly associated with type 2 diabetes in the Chinese population (p=0.004, OR=1.065, 95% CI: 1.021-1.111). Among the participants with 24≤BMI<28 kg/m2 the 8 SNPs were significantly associated with type 2 diabetes (p=0.040, OR=1.079, 95% CI: 1.003-1.160). In quantitative trait analyses, WWOX rs17797882 was associated with decreased HOMA-β and increased level of TG and HDL-Ch, while PEPD rs3786897 and MAEA rs6815464 were associated with decreased fasting plasma glucose, and KCNK16 rs1535500 has shown a significant association with increased T-Ch and PSMD6 rs831571 had a significant association with decreased HDL-Ch. In Conclusion, with high probability the 8 loci identified in the East Asian GWAS meta-analysis are associated with type 2 diabetes in the Han Chinese population.</description><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Genetic Loci</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Repetitive Sequences, Nucleic Acid - genetics</subject><subject>Risk</subject><subject>Young Adult</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFFLwzAUhYMobk5ffZT8gc7cJG3TxzHmJgx8UdhbSZobFtnakmTK_r3Vqk8X7jnfefgIuQc2ByWUetSmn3MGquaF4BdkCqWQGeRyd0mmjDHIcl7uJuQmxnfGuIBKXpOJAJB5WfIpCSsdE11Er1u6xrY7YvbpLVIdY9d4nXzX0phO9kwtBv-Blh6GP_UtDXgY49TRdO6Rcmq9Npgwfsdpj3QzjC73vsWItO_60wjckiunDxHvfu-MvD2tXpebbPuyfl4utlnDC56yAsA6LQArKaQtmClUzq1mEphkkkNTOp6jMCZXQjjRNFq7wjW6MqqqKuvEjMzH3SZ0MQZ0dR_8UYdzDaz-kVcP8up_eQPwMAL9yRzR_tf_bIkvtnlsRA</recordid><startdate>20190530</startdate><enddate>20190530</enddate><creator>Zhang, Sijia</creator><creator>Jamaspishvili, Esma</creator><creator>Tong, Huixin</creator><creator>Chen, Yongjie</creator><creator>Zhou, Zhongyu</creator><creator>Sun, Lulu</creator><creator>Kazakova, Elena</creator><creator>Hong, Qiao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190530</creationdate><title>East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population</title><author>Zhang, Sijia ; Jamaspishvili, Esma ; Tong, Huixin ; Chen, Yongjie ; Zhou, Zhongyu ; Sun, Lulu ; Kazakova, Elena ; Hong, Qiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c262t-611dfa31e9434d60b6852da041040421c7f25e3bb5833f3ccaaf6fca9b8999df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Genetic Loci</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Repetitive Sequences, Nucleic Acid - genetics</topic><topic>Risk</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Sijia</creatorcontrib><creatorcontrib>Jamaspishvili, Esma</creatorcontrib><creatorcontrib>Tong, Huixin</creatorcontrib><creatorcontrib>Chen, Yongjie</creatorcontrib><creatorcontrib>Zhou, Zhongyu</creatorcontrib><creatorcontrib>Sun, Lulu</creatorcontrib><creatorcontrib>Kazakova, Elena</creatorcontrib><creatorcontrib>Hong, Qiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta biochimica Polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Sijia</au><au>Jamaspishvili, Esma</au><au>Tong, Huixin</au><au>Chen, Yongjie</au><au>Zhou, Zhongyu</au><au>Sun, Lulu</au><au>Kazakova, Elena</au><au>Hong, Qiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population</atitle><jtitle>Acta biochimica Polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2019-05-30</date><risdate>2019</risdate><volume>66</volume><issue>2</issue><spage>159</spage><pages>159-</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>Meta-analysis of GWAS in East Asian populations had established 10 loci that were associated with type 2 diabetes. Eight of them were with genome-wide significance and two with a border line association. Since these data have not been studied in an independent Han Chinese population, we aimed to investigate the association of these susceptibility loci with type 2 diabetes in an independent Han Chinese population. We executed a case-control study in 2 000 Chinese by the SNPscan method. Firstly, the repetitive sequences of 10 loci were assessed. Next, we investigated the association of 8 SNPs out of 10 with type 2 diabetes and constructed the GRS of those 8 SNPs. Finally, the relationship of the 8 loci and diabetes-related traits was analyzed. Based on the fact, that highly repetitive sequences were detected in 2 SNPs, we investigated the remaining 8 SNPs. With the exception of four SNPs (CMIP rs16955379, PEPD rs3786897, PSMD6 rs831571, ZFAND3 rs9470794), the other SNPs had the same direction of effect (odds ratio [OR]>1.0) as in the original reports, especially GLIS3 rs7041847 and KCNK16 rs1535500 were significantly associated with type 2 diabetes (rs1535500: p=0.005, OR=1.224, 95% CI 1.062-1.409; rs7041847: p=0.035, OR=1.118, 95% CI 1.070-1.388). The GRS constructed from the 8 SNPs was significantly associated with type 2 diabetes in the Chinese population (p=0.004, OR=1.065, 95% CI: 1.021-1.111). Among the participants with 24≤BMI<28 kg/m2 the 8 SNPs were significantly associated with type 2 diabetes (p=0.040, OR=1.079, 95% CI: 1.003-1.160). In quantitative trait analyses, WWOX rs17797882 was associated with decreased HOMA-β and increased level of TG and HDL-Ch, while PEPD rs3786897 and MAEA rs6815464 were associated with decreased fasting plasma glucose, and KCNK16 rs1535500 has shown a significant association with increased T-Ch and PSMD6 rs831571 had a significant association with decreased HDL-Ch. In Conclusion, with high probability the 8 loci identified in the East Asian GWAS meta-analysis are associated with type 2 diabetes in the Han Chinese population.</abstract><cop>Poland</cop><pmid>31145772</pmid><doi>10.18388/abp.2018_2632</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Body Mass Index Case-Control Studies China Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Female Genetic Loci Genome-Wide Association Study Genotype Humans Insulin Resistance Logistic Models Male Middle Aged Obesity - complications Polymorphism, Single Nucleotide Repetitive Sequences, Nucleic Acid - genetics Risk Young Adult |
| title | East Asian Genome-wide association study derived loci in relation to type 2 diabetes in the Han Chinese population |
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