Antibacterial activity of caffeine against plant pathogenic bacteria
The objective of the present study was to evaluate the antibacterial properties of a plant secondary metabolite - caffeine. Caffeine is present in over 100 plant species. Antibacterial activity of caffeine was examined against the following plant-pathogenic bacteria: Ralstonia solanacearum (Rsol), C...
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| Veröffentlicht in: | Acta biochimica Polonica 2015, Vol.62 (3), p.605-612 |
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| container_title | Acta biochimica Polonica |
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| creator | Sledz, Wojciech Los, Emilia Paczek, Agnieszka Rischka, Jacek Motyka, Agata Zoledowska, Sabina Piosik, Jacek Lojkowska, Ewa |
| description | The objective of the present study was to evaluate the antibacterial properties of a plant secondary metabolite - caffeine. Caffeine is present in over 100 plant species. Antibacterial activity of caffeine was examined against the following plant-pathogenic bacteria: Ralstonia solanacearum (Rsol), Clavibacter michiganesis subsp. sepedonicus (Cms), Dickeya solani (Dsol), Pectobacterium atrosepticum (Pba), Pectobacterium carotovorum subsp. carotovorum (Pcc), Pseudomonas syringae pv. tomato (Pst), and Xanthomonas campestris subsp. campestris (Xcc). MIC and MBC values ranged from 5 to 20 mM and from 43 to 100 mM, respectively. Caffeine increased the bacterial generation time of all tested species and caused changes in cell morphology. The influence of caffeine on the synthesis of DNA, RNA and proteins was investigated in cultures of plant pathogenic bacteria with labelled precursors: [(3)H]thymidine, [(3)H]uridine or (14)C leucine, respectively. RNA biosynthesis was more affected than DNA or protein biosynthesis in bacterial cells treated with caffeine. Treatment of Pba with caffeine for 336 h did not induce resistance to this compound. Caffeine application reduced disease symptoms caused by Dsol on chicory leaves, potato slices, and whole potato tubers. The data presented indicate caffeine as a potential tool for the control of diseases caused by plant-pathogenic bacteria, especially under storage conditions. |
| doi_str_mv | 10.18388/abp.2015_1092 |
| format | Article |
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Caffeine is present in over 100 plant species. Antibacterial activity of caffeine was examined against the following plant-pathogenic bacteria: Ralstonia solanacearum (Rsol), Clavibacter michiganesis subsp. sepedonicus (Cms), Dickeya solani (Dsol), Pectobacterium atrosepticum (Pba), Pectobacterium carotovorum subsp. carotovorum (Pcc), Pseudomonas syringae pv. tomato (Pst), and Xanthomonas campestris subsp. campestris (Xcc). MIC and MBC values ranged from 5 to 20 mM and from 43 to 100 mM, respectively. Caffeine increased the bacterial generation time of all tested species and caused changes in cell morphology. The influence of caffeine on the synthesis of DNA, RNA and proteins was investigated in cultures of plant pathogenic bacteria with labelled precursors: [(3)H]thymidine, [(3)H]uridine or (14)C leucine, respectively. RNA biosynthesis was more affected than DNA or protein biosynthesis in bacterial cells treated with caffeine. Treatment of Pba with caffeine for 336 h did not induce resistance to this compound. Caffeine application reduced disease symptoms caused by Dsol on chicory leaves, potato slices, and whole potato tubers. The data presented indicate caffeine as a potential tool for the control of diseases caused by plant-pathogenic bacteria, especially under storage conditions.</description><identifier>ISSN: 0001-527X</identifier><identifier>EISSN: 1734-154X</identifier><identifier>DOI: 10.18388/abp.2015_1092</identifier><identifier>PMID: 26307771</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Anti-Bacterial Agents - chemistry ; Bacteria - drug effects ; Caffeine - chemistry ; Cichorium intybus - microbiology ; DNA - chemistry ; Dose-Response Relationship, Drug ; Leucine - chemistry ; Microbial Sensitivity Tests ; Pectobacterium - drug effects ; Pectobacterium carotovorum - drug effects ; Plant Diseases - microbiology ; Plant Leaves - microbiology ; Pseudomonas syringae - drug effects ; Ralstonia - drug effects ; RNA - chemistry ; Solanum tuberosum - microbiology ; Temperature ; Thymidine - chemistry ; Uridine - chemistry ; Xanthomonas campestris - drug effects</subject><ispartof>Acta biochimica Polonica, 2015, Vol.62 (3), p.605-612</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-8a0ee272021338a43447bafbac21b48cc8bd1a76d06eefa89f9656968806aeea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sledz, Wojciech</creatorcontrib><creatorcontrib>Los, Emilia</creatorcontrib><creatorcontrib>Paczek, Agnieszka</creatorcontrib><creatorcontrib>Rischka, Jacek</creatorcontrib><creatorcontrib>Motyka, Agata</creatorcontrib><creatorcontrib>Zoledowska, Sabina</creatorcontrib><creatorcontrib>Piosik, Jacek</creatorcontrib><creatorcontrib>Lojkowska, Ewa</creatorcontrib><title>Antibacterial activity of caffeine against plant pathogenic bacteria</title><title>Acta biochimica Polonica</title><addtitle>Acta Biochim Pol</addtitle><description>The objective of the present study was to evaluate the antibacterial properties of a plant secondary metabolite - caffeine. Caffeine is present in over 100 plant species. Antibacterial activity of caffeine was examined against the following plant-pathogenic bacteria: Ralstonia solanacearum (Rsol), Clavibacter michiganesis subsp. sepedonicus (Cms), Dickeya solani (Dsol), Pectobacterium atrosepticum (Pba), Pectobacterium carotovorum subsp. carotovorum (Pcc), Pseudomonas syringae pv. tomato (Pst), and Xanthomonas campestris subsp. campestris (Xcc). MIC and MBC values ranged from 5 to 20 mM and from 43 to 100 mM, respectively. Caffeine increased the bacterial generation time of all tested species and caused changes in cell morphology. The influence of caffeine on the synthesis of DNA, RNA and proteins was investigated in cultures of plant pathogenic bacteria with labelled precursors: [(3)H]thymidine, [(3)H]uridine or (14)C leucine, respectively. RNA biosynthesis was more affected than DNA or protein biosynthesis in bacterial cells treated with caffeine. Treatment of Pba with caffeine for 336 h did not induce resistance to this compound. Caffeine application reduced disease symptoms caused by Dsol on chicory leaves, potato slices, and whole potato tubers. The data presented indicate caffeine as a potential tool for the control of diseases caused by plant-pathogenic bacteria, especially under storage conditions.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Bacteria - drug effects</subject><subject>Caffeine - chemistry</subject><subject>Cichorium intybus - microbiology</subject><subject>DNA - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Leucine - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Pectobacterium - drug effects</subject><subject>Pectobacterium carotovorum - drug effects</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Leaves - microbiology</subject><subject>Pseudomonas syringae - drug effects</subject><subject>Ralstonia - drug effects</subject><subject>RNA - chemistry</subject><subject>Solanum tuberosum - microbiology</subject><subject>Temperature</subject><subject>Thymidine - chemistry</subject><subject>Uridine - chemistry</subject><subject>Xanthomonas campestris - drug effects</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRbK1ePUr-QOLM7mZ3cyz1EwpeFHoLk-1sXUnTkESh_95gbS8zc5jnhfcR4hYhQ6ecu6eqzSRgXiIU8kxM0SqdYq5X52IKAJjm0q4m4qrvvwCkwkJfiok0Cqy1OBUP82aIFfmBu0h1Mh7xJw77ZBcSTyFwbDihDcWmH5K2pmacNHzuNtxEnxy5a3ERqO755n_PxMfT4_viJV2-Pb8u5svUa8AhdQTM0kqQqJQjrbS2FYUxRWKlnfeuWiNZswbDHMgVoTC5KYxzYIiZ1Exkh1zf7fq-41C2XdxStx_Ll386ylFHedIxAncHoP2utrw-vR_7q1_RelyD</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Sledz, Wojciech</creator><creator>Los, Emilia</creator><creator>Paczek, Agnieszka</creator><creator>Rischka, Jacek</creator><creator>Motyka, Agata</creator><creator>Zoledowska, Sabina</creator><creator>Piosik, Jacek</creator><creator>Lojkowska, Ewa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2015</creationdate><title>Antibacterial activity of caffeine against plant pathogenic bacteria</title><author>Sledz, Wojciech ; Los, Emilia ; Paczek, Agnieszka ; Rischka, Jacek ; Motyka, Agata ; Zoledowska, Sabina ; Piosik, Jacek ; Lojkowska, Ewa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-8a0ee272021338a43447bafbac21b48cc8bd1a76d06eefa89f9656968806aeea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Bacteria - drug effects</topic><topic>Caffeine - chemistry</topic><topic>Cichorium intybus - microbiology</topic><topic>DNA - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Leucine - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Pectobacterium - drug effects</topic><topic>Pectobacterium carotovorum - drug effects</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Leaves - microbiology</topic><topic>Pseudomonas syringae - drug effects</topic><topic>Ralstonia - drug effects</topic><topic>RNA - chemistry</topic><topic>Solanum tuberosum - microbiology</topic><topic>Temperature</topic><topic>Thymidine - chemistry</topic><topic>Uridine - chemistry</topic><topic>Xanthomonas campestris - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sledz, Wojciech</creatorcontrib><creatorcontrib>Los, Emilia</creatorcontrib><creatorcontrib>Paczek, Agnieszka</creatorcontrib><creatorcontrib>Rischka, Jacek</creatorcontrib><creatorcontrib>Motyka, Agata</creatorcontrib><creatorcontrib>Zoledowska, Sabina</creatorcontrib><creatorcontrib>Piosik, Jacek</creatorcontrib><creatorcontrib>Lojkowska, Ewa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta biochimica Polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sledz, Wojciech</au><au>Los, Emilia</au><au>Paczek, Agnieszka</au><au>Rischka, Jacek</au><au>Motyka, Agata</au><au>Zoledowska, Sabina</au><au>Piosik, Jacek</au><au>Lojkowska, Ewa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial activity of caffeine against plant pathogenic bacteria</atitle><jtitle>Acta biochimica Polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2015</date><risdate>2015</risdate><volume>62</volume><issue>3</issue><spage>605</spage><epage>612</epage><pages>605-612</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>The objective of the present study was to evaluate the antibacterial properties of a plant secondary metabolite - caffeine. Caffeine is present in over 100 plant species. Antibacterial activity of caffeine was examined against the following plant-pathogenic bacteria: Ralstonia solanacearum (Rsol), Clavibacter michiganesis subsp. sepedonicus (Cms), Dickeya solani (Dsol), Pectobacterium atrosepticum (Pba), Pectobacterium carotovorum subsp. carotovorum (Pcc), Pseudomonas syringae pv. tomato (Pst), and Xanthomonas campestris subsp. campestris (Xcc). MIC and MBC values ranged from 5 to 20 mM and from 43 to 100 mM, respectively. Caffeine increased the bacterial generation time of all tested species and caused changes in cell morphology. The influence of caffeine on the synthesis of DNA, RNA and proteins was investigated in cultures of plant pathogenic bacteria with labelled precursors: [(3)H]thymidine, [(3)H]uridine or (14)C leucine, respectively. RNA biosynthesis was more affected than DNA or protein biosynthesis in bacterial cells treated with caffeine. Treatment of Pba with caffeine for 336 h did not induce resistance to this compound. Caffeine application reduced disease symptoms caused by Dsol on chicory leaves, potato slices, and whole potato tubers. The data presented indicate caffeine as a potential tool for the control of diseases caused by plant-pathogenic bacteria, especially under storage conditions.</abstract><cop>Switzerland</cop><pmid>26307771</pmid><doi>10.18388/abp.2015_1092</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Anti-Bacterial Agents - chemistry Bacteria - drug effects Caffeine - chemistry Cichorium intybus - microbiology DNA - chemistry Dose-Response Relationship, Drug Leucine - chemistry Microbial Sensitivity Tests Pectobacterium - drug effects Pectobacterium carotovorum - drug effects Plant Diseases - microbiology Plant Leaves - microbiology Pseudomonas syringae - drug effects Ralstonia - drug effects RNA - chemistry Solanum tuberosum - microbiology Temperature Thymidine - chemistry Uridine - chemistry Xanthomonas campestris - drug effects |
| title | Antibacterial activity of caffeine against plant pathogenic bacteria |
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