Role of the host genetic variability in the influenza A virus susceptibility

Role of the host genetic variability in the influenza A virus susceptibility

The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta biochimica Polonica 2014-01, Vol.61 (3), p.403
Hauptverfasser: Arcanjo, Ana Carolina, Mazzocco, Giovanni, de Oliveira, Silviene Fabiana, Plewczynski, Dariusz, Radomski, Jan P
Format: Artikel
Sprache:eng
Schlagworte:
Genetic Predisposition to Disease
Genetic Variation
Host-Pathogen Interactions - genetics
Humans
Influenza A virus - pathogenicity
Influenza, Human - genetics
Influenza, Human - virology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 3
container_start_page 403
container_title Acta biochimica Polonica
container_volume 61
creator Arcanjo, Ana Carolina
Mazzocco, Giovanni
de Oliveira, Silviene Fabiana
Plewczynski, Dariusz
Radomski, Jan P
description The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.
doi_str_mv 10.18388/abp.2014_1858
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_18388_abp_2014_1858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>25184407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c262t-92158b54845187e4f50230c5774834adbf6aac30a78afa46072f7f5f6af20d283</originalsourceid><addsrcrecordid>eNo9kF9LwzAUxYMork5ffZR8gdabf032OIZOYSCIwt5C2iYu0rUlaQfz01tW3dOBe865HH4I3RPIiGJKPZqiyygQrokS6gIlRDKeEsG3lygBAJIKKrczdBPjNwBlZMGv0YwKojgHmaDNe1tb3Drc7yzetbHHX7axvS_xwQRvCl_7_oh9c_J94-rBNj8GL_HBhyHiOMTSdr2fcrfoypk62rs_naPP56eP1Uu6eVu_rpabtKQ57dMFJUIVgis-zpCWOzEOg1JIyRXjpipcbkzJwEhlnOE5SOqkE-PVUaioYnOUTX_L0MYYrNNd8HsTjpqAPmHRIxZ9xjIWHqZCNxR7W53j_xzYL44UXmc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Role of the host genetic variability in the influenza A virus susceptibility</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Arcanjo, Ana Carolina ; Mazzocco, Giovanni ; de Oliveira, Silviene Fabiana ; Plewczynski, Dariusz ; Radomski, Jan P</creator><creatorcontrib>Arcanjo, Ana Carolina ; Mazzocco, Giovanni ; de Oliveira, Silviene Fabiana ; Plewczynski, Dariusz ; Radomski, Jan P</creatorcontrib><description>The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.</description><identifier>ISSN: 0001-527X</identifier><identifier>EISSN: 1734-154X</identifier><identifier>DOI: 10.18388/abp.2014_1858</identifier><identifier>PMID: 25184407</identifier><language>eng</language><publisher>Poland</publisher><subject>Genetic Predisposition to Disease ; Genetic Variation ; Host-Pathogen Interactions - genetics ; Humans ; Influenza A virus - pathogenicity ; Influenza, Human - genetics ; Influenza, Human - virology</subject><ispartof>Acta biochimica Polonica, 2014-01, Vol.61 (3), p.403</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c262t-92158b54845187e4f50230c5774834adbf6aac30a78afa46072f7f5f6af20d283</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25184407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arcanjo, Ana Carolina</creatorcontrib><creatorcontrib>Mazzocco, Giovanni</creatorcontrib><creatorcontrib>de Oliveira, Silviene Fabiana</creatorcontrib><creatorcontrib>Plewczynski, Dariusz</creatorcontrib><creatorcontrib>Radomski, Jan P</creatorcontrib><title>Role of the host genetic variability in the influenza A virus susceptibility</title><title>Acta biochimica Polonica</title><addtitle>Acta Biochim Pol</addtitle><description>The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.</description><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Humans</subject><subject>Influenza A virus - pathogenicity</subject><subject>Influenza, Human - genetics</subject><subject>Influenza, Human - virology</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF9LwzAUxYMork5ffZR8gdabf032OIZOYSCIwt5C2iYu0rUlaQfz01tW3dOBe865HH4I3RPIiGJKPZqiyygQrokS6gIlRDKeEsG3lygBAJIKKrczdBPjNwBlZMGv0YwKojgHmaDNe1tb3Drc7yzetbHHX7axvS_xwQRvCl_7_oh9c_J94-rBNj8GL_HBhyHiOMTSdr2fcrfoypk62rs_naPP56eP1Uu6eVu_rpabtKQ57dMFJUIVgis-zpCWOzEOg1JIyRXjpipcbkzJwEhlnOE5SOqkE-PVUaioYnOUTX_L0MYYrNNd8HsTjpqAPmHRIxZ9xjIWHqZCNxR7W53j_xzYL44UXmc</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Arcanjo, Ana Carolina</creator><creator>Mazzocco, Giovanni</creator><creator>de Oliveira, Silviene Fabiana</creator><creator>Plewczynski, Dariusz</creator><creator>Radomski, Jan P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140101</creationdate><title>Role of the host genetic variability in the influenza A virus susceptibility</title><author>Arcanjo, Ana Carolina ; Mazzocco, Giovanni ; de Oliveira, Silviene Fabiana ; Plewczynski, Dariusz ; Radomski, Jan P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c262t-92158b54845187e4f50230c5774834adbf6aac30a78afa46072f7f5f6af20d283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Humans</topic><topic>Influenza A virus - pathogenicity</topic><topic>Influenza, Human - genetics</topic><topic>Influenza, Human - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arcanjo, Ana Carolina</creatorcontrib><creatorcontrib>Mazzocco, Giovanni</creatorcontrib><creatorcontrib>de Oliveira, Silviene Fabiana</creatorcontrib><creatorcontrib>Plewczynski, Dariusz</creatorcontrib><creatorcontrib>Radomski, Jan P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta biochimica Polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arcanjo, Ana Carolina</au><au>Mazzocco, Giovanni</au><au>de Oliveira, Silviene Fabiana</au><au>Plewczynski, Dariusz</au><au>Radomski, Jan P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the host genetic variability in the influenza A virus susceptibility</atitle><jtitle>Acta biochimica Polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>61</volume><issue>3</issue><spage>403</spage><pages>403-</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.</abstract><cop>Poland</cop><pmid>25184407</pmid><doi>10.18388/abp.2014_1858</doi></addata></record>
fulltext fulltext
identifier ISSN: 0001-527X
ispartof Acta biochimica Polonica, 2014-01, Vol.61 (3), p.403
issn 0001-527X
1734-154X
language eng
recordid cdi_crossref_primary_10_18388_abp_2014_1858
source MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry
subjects Genetic Predisposition to Disease
Genetic Variation
Host-Pathogen Interactions - genetics
Humans
Influenza A virus - pathogenicity
Influenza, Human - genetics
Influenza, Human - virology
title Role of the host genetic variability in the influenza A virus susceptibility
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T10%3A07%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20the%20host%20genetic%20variability%20in%20the%20influenza%20A%20virus%20susceptibility&rft.jtitle=Acta%20biochimica%20Polonica&rft.au=Arcanjo,%20Ana%20Carolina&rft.date=2014-01-01&rft.volume=61&rft.issue=3&rft.spage=403&rft.pages=403-&rft.issn=0001-527X&rft.eissn=1734-154X&rft_id=info:doi/10.18388/abp.2014_1858&rft_dat=%3Cpubmed_cross%3E25184407%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25184407&rfr_iscdi=true