Cyclooxygenase pathways
This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a th...
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| Veröffentlicht in: | Acta biochimica Polonica 2014-01, Vol.61 (4), p.639 |
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| container_title | Acta biochimica Polonica |
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| creator | Korbecki, Jan Baranowska-Bosiacka, Irena Gutowska, Izabela Chlubek, Dariusz |
| description | This review compiles the current knowledge on the effects of prostanoids - arachidonic acid metabolites - on their own synthesis, activity and degradation. Interaction mechanisms between the receptors for the relevant compounds are presented, in particular with regard to the cooperation between a thromboxane A₂ and prostaglandin I₂ receptors. The questions of desensitization and internalization of receptors are discussed. The stages of the inflammatory response and tumor progression are analyzed against the background of the disruption of the synthesis of prostanoids. Special attention is given to the significance of 15-deoxy-Δ(12,14)-prostaglandin J₂ in the regulation of the synthesis of prostanoids and its role as an anti-inflammatory agent. Ultimately, therapeutic approaches as used in various treatments are discussed in the light of the available knowledge. |
| doi_str_mv | 10.18388/abp.2014_1825 |
| format | Article |
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| ispartof | Acta biochimica Polonica, 2014-01, Vol.61 (4), p.639 |
| issn | 0001-527X 1734-154X |
| language | eng |
| recordid | cdi_crossref_primary_10_18388_abp_2014_1825 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Humans Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - metabolism Receptors, Epoprostenol - metabolism Receptors, Thromboxane A2, Prostaglandin H2 - metabolism |
| title | Cyclooxygenase pathways |
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