Serum homocysteine levels in patients with probable vascular dementia
Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of...
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| Veröffentlicht in: | Medicinski glasnik 2017-08, Vol.14 (2), p.257-261 |
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| creator | Alajbegović, Salem Lepara, Orhan Hadžović-Džuvo, Almira Mutevelić-Turković, Alma Alajbegović, Lejla Zaćiragić, Asija Avdagić, Nesina Valjevac, Amina Babić, Nermina Dervišević, Amela |
| description | Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD. |
| doi_str_mv | 10.17392/916-17 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_17392_916_17</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>28786967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2297-375da73fa47f3e22217e9deed7ae50738fec2871634333238e12c849705fe5803</originalsourceid><addsrcrecordid>eNo9UEtLxDAYDKK4axX_geTmqZrkS5r0KMv6gAUP6rmk7Rc20hdJu7L_3uqunmZghmFmCLnm7I5ryMV9zrOU6xOy5EayVEipTo-ccRALchHjJ2NKZYyfk4Uw2mR5ppdk_YZhaum2b_tqH0f0HdIGd9hE6js62NFjN0b65cctHUJf2rJBurOxmhobaI3tLHt7Sc6cbSJeHTEhH4_r99Vzunl9elk9bNJKiFynoFVtNTgrtQMUQnCNeY1Ya4uKaTAOq7kaz0ACgACDXFRG5poph8owSMjtIbcKfYwBXTEE39qwLzgrfo8o5iN-WEJuDs5hKlus_31_y-EbmqFXdQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Serum homocysteine levels in patients with probable vascular dementia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Alajbegović, Salem ; Lepara, Orhan ; Hadžović-Džuvo, Almira ; Mutevelić-Turković, Alma ; Alajbegović, Lejla ; Zaćiragić, Asija ; Avdagić, Nesina ; Valjevac, Amina ; Babić, Nermina ; Dervišević, Amela</creator><creatorcontrib>Alajbegović, Salem ; Lepara, Orhan ; Hadžović-Džuvo, Almira ; Mutevelić-Turković, Alma ; Alajbegović, Lejla ; Zaćiragić, Asija ; Avdagić, Nesina ; Valjevac, Amina ; Babić, Nermina ; Dervišević, Amela</creatorcontrib><description>Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.</description><identifier>ISSN: 1840-0132</identifier><identifier>EISSN: 1840-2445</identifier><identifier>EISSN: 1840-0132</identifier><identifier>DOI: 10.17392/916-17</identifier><identifier>PMID: 28786967</identifier><language>eng</language><publisher>Bosnia and Herzegovina</publisher><subject>Aged ; Aged, 80 and over ; Brief Psychiatric Rating Scale ; Case-Control Studies ; Cognition Disorders - blood ; Cross-Sectional Studies ; Dementia, Vascular - blood ; Female ; Homocysteine - blood ; Humans ; Male</subject><ispartof>Medicinski glasnik, 2017-08, Vol.14 (2), p.257-261</ispartof><rights>Copyright© by the Medical Assotiation of Zenica-Doboj Canton.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2297-375da73fa47f3e22217e9deed7ae50738fec2871634333238e12c849705fe5803</citedby><cites>FETCH-LOGICAL-c2297-375da73fa47f3e22217e9deed7ae50738fec2871634333238e12c849705fe5803</cites><orcidid>0000-0003-3191-6356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28786967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alajbegović, Salem</creatorcontrib><creatorcontrib>Lepara, Orhan</creatorcontrib><creatorcontrib>Hadžović-Džuvo, Almira</creatorcontrib><creatorcontrib>Mutevelić-Turković, Alma</creatorcontrib><creatorcontrib>Alajbegović, Lejla</creatorcontrib><creatorcontrib>Zaćiragić, Asija</creatorcontrib><creatorcontrib>Avdagić, Nesina</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Babić, Nermina</creatorcontrib><creatorcontrib>Dervišević, Amela</creatorcontrib><title>Serum homocysteine levels in patients with probable vascular dementia</title><title>Medicinski glasnik</title><addtitle>Med Glas (Zenica)</addtitle><description>Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Case-Control Studies</subject><subject>Cognition Disorders - blood</subject><subject>Cross-Sectional Studies</subject><subject>Dementia, Vascular - blood</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><issn>1840-0132</issn><issn>1840-2445</issn><issn>1840-0132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UEtLxDAYDKK4axX_geTmqZrkS5r0KMv6gAUP6rmk7Rc20hdJu7L_3uqunmZghmFmCLnm7I5ryMV9zrOU6xOy5EayVEipTo-ccRALchHjJ2NKZYyfk4Uw2mR5ppdk_YZhaum2b_tqH0f0HdIGd9hE6js62NFjN0b65cctHUJf2rJBurOxmhobaI3tLHt7Sc6cbSJeHTEhH4_r99Vzunl9elk9bNJKiFynoFVtNTgrtQMUQnCNeY1Ya4uKaTAOq7kaz0ACgACDXFRG5poph8owSMjtIbcKfYwBXTEE39qwLzgrfo8o5iN-WEJuDs5hKlus_31_y-EbmqFXdQ</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Alajbegović, Salem</creator><creator>Lepara, Orhan</creator><creator>Hadžović-Džuvo, Almira</creator><creator>Mutevelić-Turković, Alma</creator><creator>Alajbegović, Lejla</creator><creator>Zaćiragić, Asija</creator><creator>Avdagić, Nesina</creator><creator>Valjevac, Amina</creator><creator>Babić, Nermina</creator><creator>Dervišević, Amela</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3191-6356</orcidid></search><sort><creationdate>20170801</creationdate><title>Serum homocysteine levels in patients with probable vascular dementia</title><author>Alajbegović, Salem ; Lepara, Orhan ; Hadžović-Džuvo, Almira ; Mutevelić-Turković, Alma ; Alajbegović, Lejla ; Zaćiragić, Asija ; Avdagić, Nesina ; Valjevac, Amina ; Babić, Nermina ; Dervišević, Amela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2297-375da73fa47f3e22217e9deed7ae50738fec2871634333238e12c849705fe5803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Case-Control Studies</topic><topic>Cognition Disorders - blood</topic><topic>Cross-Sectional Studies</topic><topic>Dementia, Vascular - blood</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alajbegović, Salem</creatorcontrib><creatorcontrib>Lepara, Orhan</creatorcontrib><creatorcontrib>Hadžović-Džuvo, Almira</creatorcontrib><creatorcontrib>Mutevelić-Turković, Alma</creatorcontrib><creatorcontrib>Alajbegović, Lejla</creatorcontrib><creatorcontrib>Zaćiragić, Asija</creatorcontrib><creatorcontrib>Avdagić, Nesina</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Babić, Nermina</creatorcontrib><creatorcontrib>Dervišević, Amela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Medicinski glasnik</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alajbegović, Salem</au><au>Lepara, Orhan</au><au>Hadžović-Džuvo, Almira</au><au>Mutevelić-Turković, Alma</au><au>Alajbegović, Lejla</au><au>Zaćiragić, Asija</au><au>Avdagić, Nesina</au><au>Valjevac, Amina</au><au>Babić, Nermina</au><au>Dervišević, Amela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum homocysteine levels in patients with probable vascular dementia</atitle><jtitle>Medicinski glasnik</jtitle><addtitle>Med Glas (Zenica)</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>14</volume><issue>2</issue><spage>257</spage><epage>261</epage><pages>257-261</pages><issn>1840-0132</issn><eissn>1840-2445</eissn><eissn>1840-0132</eissn><abstract>Aim To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD. Methods Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study. Results Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found. Conclusion Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.</abstract><cop>Bosnia and Herzegovina</cop><pmid>28786967</pmid><doi>10.17392/916-17</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3191-6356</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Brief Psychiatric Rating Scale Case-Control Studies Cognition Disorders - blood Cross-Sectional Studies Dementia, Vascular - blood Female Homocysteine - blood Humans Male |
| title | Serum homocysteine levels in patients with probable vascular dementia |
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