Role of conserved peptide in taurine transporter inactivation modulated by protein kinase C

Activation of protein kinase C (PKC) by the active phorbol ester 12-myristate 13-acetate (PMA, 100 nM) or phorbol-12, 13-dibutyrate (100 nM) reduced taurine uptake by 80% in oocytes given injections with cRNA from and expressing the Madin-Darby canine kidney cell taurine transporter pNCT. Inhibition...

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Veröffentlicht in:	Journal of the American Society of Nephrology 1996-10, Vol.7 (10), p.2088-2096
Hauptverfasser:	Han, X, Budreau, A M, Chesney, R W
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Animals Antibodies - immunology Antibody Specificity Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Cell Line - metabolism Conserved Sequence Dogs Enzyme Activation Female Kidney - cytology Kidney - metabolism Kinetics Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Membrane Transport Proteins Oocytes - metabolism Phosphorylation Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase C - physiology Tetradecanoylphorbol Acetate - pharmacology Xenopus laevis
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