Cholinergic inhibition of Na-K-ATPase via activation of protein kinase C in Madin-Darby canine kidney cells

Recently, it was reported that muscarinic-type cholinergic receptors coupled to the phosphoinositide messenger system are present in the rabbit inner medullary collecting duct and Madin-Darby canine kidney (MDCK) cells. The receptor density in MDCK cells is 50 times more than that in inner medullary...

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Veröffentlicht in:	Journal of the American Society of Nephrology 1993-08, Vol.4 (2), p.195-205
Hauptverfasser:	Garg, L C, Saha, P K, Mohuczy-Dominiak, D
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Alkaloids - pharmacology Animals Atropine - pharmacology Carbachol - pharmacology Cells, Cultured Dogs Enzyme Activation - drug effects Epithelium Inositol Phosphates - metabolism Isoquinolines - pharmacology Kidney - cytology Kidney - metabolism Naphthalenes - pharmacology Parasympathomimetics - pharmacology Phorbol Esters - pharmacology Piperazines - pharmacology Protein Kinase C - metabolism Receptors, Muscarinic - drug effects Receptors, Muscarinic - physiology Signal Transduction - drug effects Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Staurosporine Sulfonamides - pharmacology
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