Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence
The integrity of the peritoneal membrane in peritoneal dialysis (PD) is of major importance for adequate dialysis and fluid balance. However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid tran...
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| Veröffentlicht in: | Journal of the American Society of Nephrology 2002-04, Vol.13 (4), p.1055-1060 |
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| creator | FUSSHÖLLER, Andreas ZUR NIEDEN, Sandra GRABENSEE, Bernd PLUM, Jorg |
| description | The integrity of the peritoneal membrane in peritoneal dialysis (PD) is of major importance for adequate dialysis and fluid balance. However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid transport and to analyze the influence of treatment time, peritonitis incidence, and PD modality (continuous ambulatory PD [CAPD] or automated PD [APD]), a cross-sectional study with an extended peritoneal transport test that used dextran 70 in 2 L of glucose was performed in 23 nonselected chronic PD patients. Compared were long-term (>40 mo) with short-term PD patients (0.25/yr to those with an incidence of |
| doi_str_mv | 10.1681/ASN.V1341055 |
| format | Article |
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However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid transport and to analyze the influence of treatment time, peritonitis incidence, and PD modality (continuous ambulatory PD [CAPD] or automated PD [APD]), a cross-sectional study with an extended peritoneal transport test that used dextran 70 in 2 L of glucose was performed in 23 nonselected chronic PD patients. Compared were long-term (>40 mo) with short-term PD patients (<40 mo), CAPD with APD patients, and those with a peritonitis incidence of >0.25/yr to those with an incidence of <0.25/yr. Dialysate/plasma (D/P) ratio and mass transfer area coefficient of creatinine, lymphatic absorption rate (LAR), transcapillary ultrafiltration, and effective ultrafiltration were measured. Long-term PD patients had higher D/P ratio of creatinine (73.5 +/- 2.3% versus 65.9 +/- 2.2%; P < 0.01) and higher LAR (243 +/- 69 ml/4 h versus 96 +/- 31 ml/4 h; P < 0.03), both resulting in lower effective ultrafiltration (242 +/- 35 ml/4 h versus 324 +/- 30 ml/4 h; P < 0.05). D/P ratio (r = 0.66) and LAR (r = 0.67) were positively correlated to PD duration. Patients on APD compared with those on CAPD and patients with a history of peritonitis compared with those without did not differ in terms of D/P ratio, mass transfer area coefficient, LAR, transcapillary ultrafiltration, and effective ultrafiltration. Lower ultrafiltration after long-term PD is both the result of increased small solute transport and increased lymphatic absorption. APD or CAPD modality and peritonitis incidence do not have a significant influence on small solute transport or fluid kinetics.</description><identifier>ISSN: 1046-6673</identifier><identifier>EISSN: 1533-3450</identifier><identifier>DOI: 10.1681/ASN.V1341055</identifier><identifier>PMID: 11912266</identifier><identifier>CODEN: JASNEU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Ascitic Fluid - metabolism ; Automation ; Biological and medical sciences ; Biological Transport ; Cross-Sectional Studies ; Dextrans - pharmacokinetics ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Humans ; Incidence ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Peritoneal Dialysis - adverse effects ; Peritoneal Dialysis - methods ; Peritoneal Dialysis, Continuous Ambulatory - adverse effects ; Peritonitis - epidemiology ; Peritonitis - etiology ; Time Factors</subject><ispartof>Journal of the American Society of Nephrology, 2002-04, Vol.13 (4), p.1055-1060</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13613997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11912266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUSSHÖLLER, Andreas</creatorcontrib><creatorcontrib>ZUR NIEDEN, Sandra</creatorcontrib><creatorcontrib>GRABENSEE, Bernd</creatorcontrib><creatorcontrib>PLUM, Jorg</creatorcontrib><title>Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence</title><title>Journal of the American Society of Nephrology</title><addtitle>J Am Soc Nephrol</addtitle><description>The integrity of the peritoneal membrane in peritoneal dialysis (PD) is of major importance for adequate dialysis and fluid balance. However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid transport and to analyze the influence of treatment time, peritonitis incidence, and PD modality (continuous ambulatory PD [CAPD] or automated PD [APD]), a cross-sectional study with an extended peritoneal transport test that used dextran 70 in 2 L of glucose was performed in 23 nonselected chronic PD patients. Compared were long-term (>40 mo) with short-term PD patients (<40 mo), CAPD with APD patients, and those with a peritonitis incidence of >0.25/yr to those with an incidence of <0.25/yr. Dialysate/plasma (D/P) ratio and mass transfer area coefficient of creatinine, lymphatic absorption rate (LAR), transcapillary ultrafiltration, and effective ultrafiltration were measured. Long-term PD patients had higher D/P ratio of creatinine (73.5 +/- 2.3% versus 65.9 +/- 2.2%; P < 0.01) and higher LAR (243 +/- 69 ml/4 h versus 96 +/- 31 ml/4 h; P < 0.03), both resulting in lower effective ultrafiltration (242 +/- 35 ml/4 h versus 324 +/- 30 ml/4 h; P < 0.05). D/P ratio (r = 0.66) and LAR (r = 0.67) were positively correlated to PD duration. Patients on APD compared with those on CAPD and patients with a history of peritonitis compared with those without did not differ in terms of D/P ratio, mass transfer area coefficient, LAR, transcapillary ultrafiltration, and effective ultrafiltration. Lower ultrafiltration after long-term PD is both the result of increased small solute transport and increased lymphatic absorption. APD or CAPD modality and peritonitis incidence do not have a significant influence on small solute transport or fluid kinetics.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Ascitic Fluid - metabolism</subject><subject>Automation</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Cross-Sectional Studies</subject><subject>Dextrans - pharmacokinetics</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>Peritoneal Dialysis - methods</subject><subject>Peritoneal Dialysis, Continuous Ambulatory - adverse effects</subject><subject>Peritonitis - epidemiology</subject><subject>Peritonitis - etiology</subject><subject>Time Factors</subject><issn>1046-6673</issn><issn>1533-3450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAURi0EoqWwMSMvbE2xY_s6YasqHpUqQOKxRo7tSEZ5KXaHij-PS4M63cd39A0HoWtKFhQyerd8f1l8UcYpEeIETalgLGFckNO4Ew4JgGQTdOH9NyFUpFKeowmlOU1TgCn6ebODC11rVY2reusMVq3Bvqu3weIwqNb33RDu8bqNqW21xV0V_1aFxrYBB9fYOe6PHcapeuedx01nVO3Cbv5XOBIuxMS12pl91SU6q1Tt7dU4Z-jz8eFj9ZxsXp_Wq-Um0amEkKgMFHCRG6sZqSDTKVGCECMJI7aMF815ySpFS2t5CiWAETKjKZcl0QY4m6H5oVcPnfeDrYp-cI0adgUlxd5hER0W_w4jfnPA-23ZWHOER2kRuB0B5bWqq2hJO3_kGFCW55L9AqtKe8E</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>FUSSHÖLLER, Andreas</creator><creator>ZUR NIEDEN, Sandra</creator><creator>GRABENSEE, Bernd</creator><creator>PLUM, Jorg</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20020401</creationdate><title>Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence</title><author>FUSSHÖLLER, Andreas ; ZUR NIEDEN, Sandra ; GRABENSEE, Bernd ; PLUM, Jorg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-a86a6459dec30f68c20a500d7030ebc20194b3fa1bee426b66d5781247b0cd643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Ascitic Fluid - metabolism</topic><topic>Automation</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Cross-Sectional Studies</topic><topic>Dextrans - pharmacokinetics</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peritoneal Dialysis - adverse effects</topic><topic>Peritoneal Dialysis - methods</topic><topic>Peritoneal Dialysis, Continuous Ambulatory - adverse effects</topic><topic>Peritonitis - epidemiology</topic><topic>Peritonitis - etiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUSSHÖLLER, Andreas</creatorcontrib><creatorcontrib>ZUR NIEDEN, Sandra</creatorcontrib><creatorcontrib>GRABENSEE, Bernd</creatorcontrib><creatorcontrib>PLUM, Jorg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUSSHÖLLER, Andreas</au><au>ZUR NIEDEN, Sandra</au><au>GRABENSEE, Bernd</au><au>PLUM, Jorg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>13</volume><issue>4</issue><spage>1055</spage><epage>1060</epage><pages>1055-1060</pages><issn>1046-6673</issn><eissn>1533-3450</eissn><coden>JASNEU</coden><abstract>The integrity of the peritoneal membrane in peritoneal dialysis (PD) is of major importance for adequate dialysis and fluid balance. However, alterations in peritoneal fluid transport, such as ultrafiltration failure, often develop during long-term PD. To investigate peritoneal solute and fluid transport and to analyze the influence of treatment time, peritonitis incidence, and PD modality (continuous ambulatory PD [CAPD] or automated PD [APD]), a cross-sectional study with an extended peritoneal transport test that used dextran 70 in 2 L of glucose was performed in 23 nonselected chronic PD patients. Compared were long-term (>40 mo) with short-term PD patients (<40 mo), CAPD with APD patients, and those with a peritonitis incidence of >0.25/yr to those with an incidence of <0.25/yr. Dialysate/plasma (D/P) ratio and mass transfer area coefficient of creatinine, lymphatic absorption rate (LAR), transcapillary ultrafiltration, and effective ultrafiltration were measured. Long-term PD patients had higher D/P ratio of creatinine (73.5 +/- 2.3% versus 65.9 +/- 2.2%; P < 0.01) and higher LAR (243 +/- 69 ml/4 h versus 96 +/- 31 ml/4 h; P < 0.03), both resulting in lower effective ultrafiltration (242 +/- 35 ml/4 h versus 324 +/- 30 ml/4 h; P < 0.05). D/P ratio (r = 0.66) and LAR (r = 0.67) were positively correlated to PD duration. Patients on APD compared with those on CAPD and patients with a history of peritonitis compared with those without did not differ in terms of D/P ratio, mass transfer area coefficient, LAR, transcapillary ultrafiltration, and effective ultrafiltration. Lower ultrafiltration after long-term PD is both the result of increased small solute transport and increased lymphatic absorption. APD or CAPD modality and peritonitis incidence do not have a significant influence on small solute transport or fluid kinetics.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11912266</pmid><doi>10.1681/ASN.V1341055</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Ascitic Fluid - metabolism Automation Biological and medical sciences Biological Transport Cross-Sectional Studies Dextrans - pharmacokinetics Emergency and intensive care: renal failure. Dialysis management Female Humans Incidence Intensive care medicine Male Medical sciences Middle Aged Peritoneal Dialysis - adverse effects Peritoneal Dialysis - methods Peritoneal Dialysis, Continuous Ambulatory - adverse effects Peritonitis - epidemiology Peritonitis - etiology Time Factors |
| title | Peritoneal fluid and solute transport: Influence of treatment time, peritoneal dialysis modality, and peritonitis incidence |
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