Activated coagulation factor X: A novel mitogenic stimulus for human mesangial cells

Intraglomerular activation of the coagulation cascade is a common feature of mesangioproliferative glomerulonephritis. Besides thrombin, very little is known about the cellular effects of other components of the coagulation system. This study investigated the effect of activated factor X (FXa) on cu...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2001-05, Vol.12 (5), p.891-899
Hauptverfasser:	MONNO, Raffaella, GRANDALIANO, Giuseppe, FACCIO, Roberta, RANIERI, Elena, MARTINO, Carmela, GESUALDO, Loreto, SCHENA, Francesco P
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Calcium Signaling - drug effects Cells, Cultured DNA - biosynthesis DNA Primers - genetics Factor Xa - pharmacology Gene Expression - drug effects Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Glomerulonephritis Glomerulonephritis, Membranoproliferative - etiology Humans Inhibitor of Apoptosis Proteins Medical sciences Mitogens - pharmacology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Platelet-Derived Growth Factor - genetics Protein Kinase C - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-sis - genetics Receptors, Cell Surface - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Survivin Type C Phospholipases - metabolism
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