Trends of analgesic nephropathy in two high-endemic regions with different legislation
Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained f...
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| Veröffentlicht in: | Journal of the American Society of Nephrology 2001-03, Vol.12 (3), p.550-556 |
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| container_title | Journal of the American Society of Nephrology |
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| creator | MICHIELSEN, Paul DE SCHEPPER, Paul |
| description | Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined analgesics were also prohibited. This study compared the evolution of end-stage renal disease as a result of analgesic nephropathy (AN) in these two high-endemic regions with different legislation. In both regions, the time trend of the age-specific incidence of end-stage renal disease as a result of AN is similar in the age group 45 to 54 yr. In all age groups combined, the time trend of the percentage of AN among the patients admitted for renal replacement therapy is also similar. This finding does not support the hypothesis that non-phenacetin mixed analgesics play a significant role in the occurrence of AN. |
| doi_str_mv | 10.1681/ASN.V123550 |
| format | Article |
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In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined analgesics were also prohibited. This study compared the evolution of end-stage renal disease as a result of analgesic nephropathy (AN) in these two high-endemic regions with different legislation. In both regions, the time trend of the age-specific incidence of end-stage renal disease as a result of AN is similar in the age group 45 to 54 yr. In all age groups combined, the time trend of the percentage of AN among the patients admitted for renal replacement therapy is also similar. This finding does not support the hypothesis that non-phenacetin mixed analgesics play a significant role in the occurrence of AN.</description><identifier>ISSN: 1046-6673</identifier><identifier>EISSN: 1533-3450</identifier><identifier>DOI: 10.1681/ASN.V123550</identifier><identifier>PMID: 11181803</identifier><identifier>CODEN: JASNEU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Analgesics - adverse effects ; Belgium - epidemiology ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Humans ; Kidney Failure, Chronic - chemically induced ; Kidney Failure, Chronic - epidemiology ; Legislation, Drug ; Medical sciences ; Middle Aged ; Nephritis, Interstitial - chemically induced ; Nephritis, Interstitial - epidemiology ; New South Wales - epidemiology ; Pharmacology. 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In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined analgesics were also prohibited. This study compared the evolution of end-stage renal disease as a result of analgesic nephropathy (AN) in these two high-endemic regions with different legislation. In both regions, the time trend of the age-specific incidence of end-stage renal disease as a result of AN is similar in the age group 45 to 54 yr. In all age groups combined, the time trend of the percentage of AN among the patients admitted for renal replacement therapy is also similar. This finding does not support the hypothesis that non-phenacetin mixed analgesics play a significant role in the occurrence of AN.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics - adverse effects</subject><subject>Belgium - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - chemically induced</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Legislation, Drug</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephritis, Interstitial - chemically induced</subject><subject>Nephritis, Interstitial - epidemiology</subject><subject>New South Wales - epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenacetin - adverse effects</subject><subject>Substance-Related Disorders - complications</subject><subject>Time Factors</subject><subject>Toxicity: urogenital system</subject><issn>1046-6673</issn><issn>1533-3450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LwzAYxoMobk5P3iXgUapvms8dx_ALhh6cu5Y0TdZI15akMvbfG1nR0_vwPj-eww-hawL3RCjysPh4u9-QnHIOJ2hKOKUZZRxOUwYmMiEknaCLGL8ACM-lPEcTQogiCugUbdbBtlXEncO61c3WRm9wa_s6dL0e6gP2LR72Ha79ts4SaXepD3bruzbivR9qXHnnbBoZcJPesdFD6i7RmdNNtFfjnaHPp8f18iVbvT-_LherzFAOQyaUFIwQ5lzFS-VKYVQuKa9KAHBu7hyfM6qpFJIBz41gUhnQvDSSgshLQmfo7rhrQhdjsK7og9_pcCgIFL92imSnGO0k-uZI99_lzlb_7KgjAbcjoKPRjQu6NT7-cXPgSgD9AcKEbFE</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>MICHIELSEN, Paul</creator><creator>DE SCHEPPER, Paul</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010301</creationdate><title>Trends of analgesic nephropathy in two high-endemic regions with different legislation</title><author>MICHIELSEN, Paul ; DE SCHEPPER, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-68764114ffd5b8fb6c82735db000ff9ff5943a37674052c6478c0a5bc73062b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics - adverse effects</topic><topic>Belgium - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - chemically induced</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Legislation, Drug</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephritis, Interstitial - chemically induced</topic><topic>Nephritis, Interstitial - epidemiology</topic><topic>New South Wales - epidemiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenacetin - adverse effects</topic><topic>Substance-Related Disorders - complications</topic><topic>Time Factors</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MICHIELSEN, Paul</creatorcontrib><creatorcontrib>DE SCHEPPER, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MICHIELSEN, Paul</au><au>DE SCHEPPER, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends of analgesic nephropathy in two high-endemic regions with different legislation</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>12</volume><issue>3</issue><spage>550</spage><epage>556</epage><pages>550-556</pages><issn>1046-6673</issn><eissn>1533-3450</eissn><coden>JASNEU</coden><abstract>Analgesic abuse is related to a specific form of interstitial nephritis, but the exact nature of the causal agent remains controversial and this has resulted in differences in regulation. In Flanders, the free sale of phenacetin was banned, but the consumption of other combined analgesics remained free. In New South Wales, phenacetin was also banned, but 2 yr later the sales of all combined analgesics were also prohibited. This study compared the evolution of end-stage renal disease as a result of analgesic nephropathy (AN) in these two high-endemic regions with different legislation. In both regions, the time trend of the age-specific incidence of end-stage renal disease as a result of AN is similar in the age group 45 to 54 yr. In all age groups combined, the time trend of the percentage of AN among the patients admitted for renal replacement therapy is also similar. This finding does not support the hypothesis that non-phenacetin mixed analgesics play a significant role in the occurrence of AN.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11181803</pmid><doi>10.1681/ASN.V123550</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American Society of Nephrology, 2001-03, Vol.12 (3), p.550-556 |
| issn | 1046-6673 1533-3450 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Analgesics - adverse effects Belgium - epidemiology Biological and medical sciences Drug toxicity and drugs side effects treatment Humans Kidney Failure, Chronic - chemically induced Kidney Failure, Chronic - epidemiology Legislation, Drug Medical sciences Middle Aged Nephritis, Interstitial - chemically induced Nephritis, Interstitial - epidemiology New South Wales - epidemiology Pharmacology. Drug treatments Phenacetin - adverse effects Substance-Related Disorders - complications Time Factors Toxicity: urogenital system |
| title | Trends of analgesic nephropathy in two high-endemic regions with different legislation |
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