Podocyte depletion causes glomerulosclerosis : Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene

Glomerular injury and proteinuria in diabetes (types 1 and 2) and IgA nephropathy is related to the degree of podocyte depletion in humans. For determining the causal relationship between podocyte depletion and glomerulosclerosis, a transgenic rat strain in which the human diphtheria toxin receptor...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2005-10, Vol.16 (10), p.2941-2952
Hauptverfasser:	WHARRAM, Bryan L, GOYAL, Meera, WIGGINS, Roger C, WIGGINS, Jocelyn E, SANDEN, Silja K, HUSSAIN, Sabiha, FILIPIAK, Wanda E, SAUNDERS, Thomas L, DYSKO, Robert C, KOHNO, Kenji, HOLZMAN, Lawrence B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Count Diphtheria Toxin - pharmacology Glomerulonephritis Glomerulosclerosis, Focal Segmental - etiology Heparin-binding EGF-like Growth Factor Humans Intercellular Signaling Peptides and Proteins Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Podocytes - drug effects Podocytes - physiology Rats Rats, Inbred F344 Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Transgenes
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