Specific dose-dependent effects of ethane 1,2-dimethanesulfonate in rat and mouse Leydig cells and non-steroidogenic cells on programmed cell death

The mechanism by which ethane 1,2-dimethanesulfonate (EDS) selectively kills Leydig cells is poorly understood. To characterize further the cell-specific actions of EDS, we studied biochemical and morphological changes during apoptosis in different Leydig cell and non-steroidogenic cell models.Rat t...

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Veröffentlicht in:	Journal of endocrinology 2004-04, Vol.181 (1), p.169-178
Hauptverfasser:	Rommerts, FF, Kuhne, L, van Cappellen, GW, Stocco, DM, King, SR, Jankowska, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Animals Apoptosis - drug effects Biological and medical sciences Cell Line Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - ultrastructure Chemical and industrial products toxicology. Toxic occupational diseases DNA Fragmentation Dose-Response Relationship, Drug Leydig Cells - cytology Leydig Cells - ultrastructure Male Medical sciences Mesylates - pharmacology Mice Microscopy, Confocal Microscopy, Electron Mitochondria - drug effects Mitochondria - ultrastructure Necrosis Rats Time Factors Toxicology Various organic compounds
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