Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner

MIF is a potent proinflammatory cytokine involved in inflammatory arthritis. Glucocorticoids (GC) have been reported to induce secretion of MIF in rodent cells, and as MIF counteracts the anti-inflammatory effects of GC, this has implications for human inflammatory disease. Transient transfection st...

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Veröffentlicht in:	Journal of molecular endocrinology 2005-04, Vol.34 (2), p.583-595
Hauptverfasser:	Alourfi, Z, Donn, R P, Stevens, A, Berry, A, McMaster, A, Ray, D W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cyclic AMP - metabolism Gene Expression Regulation Glucocorticoids - metabolism Humans Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Molecular Sequence Data Promoter Regions, Genetic Rats Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Regular papers RNA, Messenger - metabolism Tetradecanoylphorbol Acetate - metabolism
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