Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease

Exendin-4 is a naturally occurring more potent and stable analog of glucagon-like peptide-1 (GLP-1) that selectively binds at the GLP-1 receptor. It has been recently demonstrated that GLP-1 receptor stimulation preserves dopaminergic neurons in cellular and rodent models of Parkinson's disease...

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Veröffentlicht in:	Journal of endocrinology 2009-09, Vol.202 (3), p.431-439
Hauptverfasser:	Kim, Sehee, Moon, Minho, Park, Seungjoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corpus Striatum - drug effects Corpus Striatum - immunology Corpus Striatum - pathology Disease Models, Animal Dopamine - physiology Gene Expression Regulation, Enzymologic - drug effects Gliosis - drug therapy Gliosis - immunology Gliosis - pathology Hypoglycemic Agents - pharmacology Inflammation Mediators - metabolism Male Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase Inhibitors Mice Mice, Inbred C57BL Microglia - drug effects Microglia - immunology Microglia - pathology Neuroprotective Agents - pharmacology Parkinsonian Disorders - drug therapy Parkinsonian Disorders - immunology Parkinsonian Disorders - pathology Peptides - pharmacology Regular papers Substantia Nigra - drug effects Substantia Nigra - immunology Substantia Nigra - pathology Venoms - pharmacology
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