Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas
Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer...
Gespeichert in:
| Veröffentlicht in: | Endocrine-related cancer 2010-03, Vol.17 (1), p.F91-F104 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | F104 |
|---|---|
| container_issue | 1 |
| container_start_page | F91 |
| container_title | Endocrine-related cancer |
| container_volume | 17 |
| creator | Pallante, Pierlorenzo Visone, Rosa Croce, Carlo Maria Fusco, Alfredo |
| description | Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms. |
| doi_str_mv | 10.1677/ERC-09-0217 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1677_ERC_09_0217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19942715</sourcerecordid><originalsourceid>FETCH-LOGICAL-b476t-e9cf5c2832c0adf7b7e4727a5e2135a6809499c8db61ee78b8eb46c28bd449ce3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlZP3iV3iSZpdpMcS60fUBSK4nHJZmfbyH6UZKv235uyFcWDpxmG5x1eHoTOGb1iqZTXs8WUUE0oZ_IADZmQmqSKs8O4jxNGKFVqgE5CeKOUpipJjtGAaS24ZMkQvd6Ah-WmMp1rG9yWuHbWt4vHCYbPtYcQdmfX4LKtKmcj57GFqiIFePcOBV5tatPgbrX1rSuwNd66pq1NOEVHpakCnO3nCL3czp6n92T-dPcwncxJLmTaEdC2TCxXY26pKUqZSxCSS5MAj-VNqqgWWltV5CkDkCpXkIs0BvJCCG1hPEKX_d_YOgQPZbb2rjZ-mzGa7fRkUU9GdbbTE-mLnl5v8hqKH3bvIwK8B1ZuufpwHrLctcE6aDpXOmt-f_2WHkOsD_1h_2vyBVhsghg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Society for Endocrinology Journals</source><creator>Pallante, Pierlorenzo ; Visone, Rosa ; Croce, Carlo Maria ; Fusco, Alfredo</creator><creatorcontrib>Pallante, Pierlorenzo ; Visone, Rosa ; Croce, Carlo Maria ; Fusco, Alfredo</creatorcontrib><description>Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.</description><identifier>ISSN: 1351-0088</identifier><identifier>EISSN: 1479-6821</identifier><identifier>DOI: 10.1677/ERC-09-0217</identifier><identifier>PMID: 19942715</identifier><language>eng</language><publisher>England: Society for Endocrinology</publisher><subject>Adenocarcinoma, Follicular - diagnosis ; Adenocarcinoma, Follicular - genetics ; Adenocarcinoma, Follicular - pathology ; Animals ; Biomarkers, Tumor - analysis ; Carcinoma - diagnosis ; Carcinoma, Papillary - diagnosis ; Cell Transformation, Neoplastic - genetics ; Diagnosis, Differential ; Focus Review ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Transgenic ; MicroRNAs - analysis ; MicroRNAs - genetics ; Mutation ; Neoplasms, Radiation-Induced - diagnosis ; Neoplasms, Radiation-Induced - genetics ; Neoplasms, Radiation-Induced - pathology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; RNA, Neoplasm - analysis ; RNA, Neoplasm - genetics ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology</subject><ispartof>Endocrine-related cancer, 2010-03, Vol.17 (1), p.F91-F104</ispartof><rights>2010 Society for Endocrinology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-e9cf5c2832c0adf7b7e4727a5e2135a6809499c8db61ee78b8eb46c28bd449ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3948,3949,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19942715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pallante, Pierlorenzo</creatorcontrib><creatorcontrib>Visone, Rosa</creatorcontrib><creatorcontrib>Croce, Carlo Maria</creatorcontrib><creatorcontrib>Fusco, Alfredo</creatorcontrib><title>Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas</title><title>Endocrine-related cancer</title><addtitle>Endocr Relat Cancer</addtitle><description>Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.</description><subject>Adenocarcinoma, Follicular - diagnosis</subject><subject>Adenocarcinoma, Follicular - genetics</subject><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Animals</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Diagnosis, Differential</subject><subject>Focus Review</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>MicroRNAs - analysis</subject><subject>MicroRNAs - genetics</subject><subject>Mutation</subject><subject>Neoplasms, Radiation-Induced - diagnosis</subject><subject>Neoplasms, Radiation-Induced - genetics</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncogenes</subject><subject>RNA, Neoplasm - analysis</subject><subject>RNA, Neoplasm - genetics</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><issn>1351-0088</issn><issn>1479-6821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZP3iV3iSZpdpMcS60fUBSK4nHJZmfbyH6UZKv235uyFcWDpxmG5x1eHoTOGb1iqZTXs8WUUE0oZ_IADZmQmqSKs8O4jxNGKFVqgE5CeKOUpipJjtGAaS24ZMkQvd6Ah-WmMp1rG9yWuHbWt4vHCYbPtYcQdmfX4LKtKmcj57GFqiIFePcOBV5tatPgbrX1rSuwNd66pq1NOEVHpakCnO3nCL3czp6n92T-dPcwncxJLmTaEdC2TCxXY26pKUqZSxCSS5MAj-VNqqgWWltV5CkDkCpXkIs0BvJCCG1hPEKX_d_YOgQPZbb2rjZ-mzGa7fRkUU9GdbbTE-mLnl5v8hqKH3bvIwK8B1ZuufpwHrLctcE6aDpXOmt-f_2WHkOsD_1h_2vyBVhsghg</recordid><startdate>201003</startdate><enddate>201003</enddate><creator>Pallante, Pierlorenzo</creator><creator>Visone, Rosa</creator><creator>Croce, Carlo Maria</creator><creator>Fusco, Alfredo</creator><general>Society for Endocrinology</general><general>BioScientifica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201003</creationdate><title>Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas</title><author>Pallante, Pierlorenzo ; Visone, Rosa ; Croce, Carlo Maria ; Fusco, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-e9cf5c2832c0adf7b7e4727a5e2135a6809499c8db61ee78b8eb46c28bd449ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma, Follicular - diagnosis</topic><topic>Adenocarcinoma, Follicular - genetics</topic><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Animals</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Diagnosis, Differential</topic><topic>Focus Review</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>MicroRNAs - analysis</topic><topic>MicroRNAs - genetics</topic><topic>Mutation</topic><topic>Neoplasms, Radiation-Induced - diagnosis</topic><topic>Neoplasms, Radiation-Induced - genetics</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncogenes</topic><topic>RNA, Neoplasm - analysis</topic><topic>RNA, Neoplasm - genetics</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pallante, Pierlorenzo</creatorcontrib><creatorcontrib>Visone, Rosa</creatorcontrib><creatorcontrib>Croce, Carlo Maria</creatorcontrib><creatorcontrib>Fusco, Alfredo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Endocrine-related cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pallante, Pierlorenzo</au><au>Visone, Rosa</au><au>Croce, Carlo Maria</au><au>Fusco, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas</atitle><jtitle>Endocrine-related cancer</jtitle><addtitle>Endocr Relat Cancer</addtitle><date>2010-03</date><risdate>2010</risdate><volume>17</volume><issue>1</issue><spage>F91</spage><epage>F104</epage><pages>F91-F104</pages><issn>1351-0088</issn><eissn>1479-6821</eissn><abstract>Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.</abstract><cop>England</cop><pub>Society for Endocrinology</pub><pmid>19942715</pmid><doi>10.1677/ERC-09-0217</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-0088 |
| ispartof | Endocrine-related cancer, 2010-03, Vol.17 (1), p.F91-F104 |
| issn | 1351-0088 1479-6821 |
| language | eng |
| recordid | cdi_crossref_primary_10_1677_ERC_09_0217 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Society for Endocrinology Journals |
| subjects | Adenocarcinoma, Follicular - diagnosis Adenocarcinoma, Follicular - genetics Adenocarcinoma, Follicular - pathology Animals Biomarkers, Tumor - analysis Carcinoma - diagnosis Carcinoma, Papillary - diagnosis Cell Transformation, Neoplastic - genetics Diagnosis, Differential Focus Review Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Mice Mice, Transgenic MicroRNAs - analysis MicroRNAs - genetics Mutation Neoplasms, Radiation-Induced - diagnosis Neoplasms, Radiation-Induced - genetics Neoplasms, Radiation-Induced - pathology Oligonucleotide Array Sequence Analysis Oncogenes RNA, Neoplasm - analysis RNA, Neoplasm - genetics Thyroid Neoplasms - diagnosis Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology |
| title | Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T00%3A33%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deregulation%20of%20microRNA%20expression%20in%20follicular%20cell-derived%20human%20thyroid%20carcinomas&rft.jtitle=Endocrine-related%20cancer&rft.au=Pallante,%20Pierlorenzo&rft.date=2010-03&rft.volume=17&rft.issue=1&rft.spage=F91&rft.epage=F104&rft.pages=F91-F104&rft.issn=1351-0088&rft.eissn=1479-6821&rft_id=info:doi/10.1677/ERC-09-0217&rft_dat=%3Cpubmed_cross%3E19942715%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19942715&rfr_iscdi=true |