Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines
Kim, K-U., Xiao, J., Ni, H-T., Cho, K. H., Spellman, S. R., Low, W. C. and Hall, W. A. Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines. Radiat. Res. 160, 224–231 (2003). Various imm...
Gespeichert in:
| Veröffentlicht in: | Radiation research 2003-08, Vol.160 (2), p.224-231 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 231 |
|---|---|
| container_issue | 2 |
| container_start_page | 224 |
| container_title | Radiation research |
| container_volume | 160 |
| creator | Kim, Ki-Uk Xiao, Jing Ni, Hsiao-Tzu Cho, Kwan H. Spellman, Stephen R. Low, Walter C. Hall, Walter A. |
| description | Kim, K-U., Xiao, J., Ni, H-T., Cho, K. H., Spellman, S. R., Low, W. C. and Hall, W. A. Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines. Radiat. Res. 160, 224–231 (2003). Various immunotoxins have been developed for the treatment of cancer. The toxin is internalized by target cells through cell-surface receptors, and it is essential for these receptors to be expressed for the immunotoxin to have specific anti-tumor activity. Radiation therapy is one of the main treatment modalities for primary malignant brain tumors. The purpose of this study was to determine whether radiation influences the expression of cell-surface receptors. Cells of one human medulloblastoma (Daoy) and two glioblastoma (U373-MG and T98-G) cell lines were tested by exposing the cells to a single dose of 5 Gy γ rays. Expression of transferrin receptors, type-1 insulin-like growth factor receptors (IGF1R), and interleukin 4 receptors (IL4R) was measured by flow cytometry analysis on unirradiated cells and on cells 3 to 120 h after irradiation. In Daoy cells, the absolute expression index of transferrin receptors increased during the 24 h after irradiation with the greatest change of 26% above control at 9 h. The absolute expression index of IGF1R increased 26.5% above control at 12 h. The absolute expression index of IL4R decreased 9 h after irradiation. In U373-MG cells the absolute expression index of transferrin receptors increased during the 24 h after irradiation, and the greatest increase was 45% above control at 9 h. The absolute expression index of IGF1R increased during the 12 h after irradiation with a maximum increase of 33% above control at 6 h. The absolute expression index of IL4R decreased with time after irradiation. In T98-G cells, the absolute expression index of both transferrin receptors and IL4R decreased after irradiation. The results suggest that the expression of growth factor receptors on brain tumor cells may be influenced by radiation. The effect of ionizing radiation on receptor expression should be considered when administration of targeted toxin is combined with radiation. Similar studies with other growth factor receptors used in targeted toxin therapy are recommended. |
| doi_str_mv | 10.1667/RR3040 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1667_RR3040</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3581171</jstor_id><sourcerecordid>3581171</sourcerecordid><originalsourceid>FETCH-LOGICAL-b355t-67952cfd9e1217fa3b435d0d1b25aff2e74fe3cc834ea0cb7b9cfdd908a64e463</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMoWm9PIJKFunI0mSRzWWrxUqgopa7LmcyJRqeZkkxRX8jnNGWKrlydnPwfH4efkEPOLniW5ZeTiWCSbZABL0WRKMnkJhkwJkSSqyLfIbshvLG486zcJjs8LVSZCjkg38NXcC8YqHX05nPhMQTbOtoaOvXggkHvrTunIxeWjXVJY9-R3vn2o3ult6C71lN-TsHVkejQN7h8jyJJJ6hxEdNAwcR_OvIeagvd2j3Epgmrx5O3c_Bf9AEa--LAdfTaQzRMl_OoXmF0bB2GfbJloAl4sJ575Pn2Zjq8T8aPd6Ph1TiphFJdkuWlSrWpS-Qpzw2ISgpVs5pXqQJjUsylQaF1ISQC01VelZGuS1ZAJlFmYo-c9V7t2xA8mtmiv3DG2WxV9KwvOoLHPbhYVnOs_7B1sxE4XQMQNDQmtqlt-OMUS5lSaeSOeu4txL5-c6EKznMe45M-rmzbOvzvnB8iAZxR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines</title><source>MEDLINE</source><source>BioOne Complete</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Kim, Ki-Uk ; Xiao, Jing ; Ni, Hsiao-Tzu ; Cho, Kwan H. ; Spellman, Stephen R. ; Low, Walter C. ; Hall, Walter A.</creator><creatorcontrib>Kim, Ki-Uk ; Xiao, Jing ; Ni, Hsiao-Tzu ; Cho, Kwan H. ; Spellman, Stephen R. ; Low, Walter C. ; Hall, Walter A.</creatorcontrib><description>Kim, K-U., Xiao, J., Ni, H-T., Cho, K. H., Spellman, S. R., Low, W. C. and Hall, W. A. Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines. Radiat. Res. 160, 224–231 (2003). Various immunotoxins have been developed for the treatment of cancer. The toxin is internalized by target cells through cell-surface receptors, and it is essential for these receptors to be expressed for the immunotoxin to have specific anti-tumor activity. Radiation therapy is one of the main treatment modalities for primary malignant brain tumors. The purpose of this study was to determine whether radiation influences the expression of cell-surface receptors. Cells of one human medulloblastoma (Daoy) and two glioblastoma (U373-MG and T98-G) cell lines were tested by exposing the cells to a single dose of 5 Gy γ rays. Expression of transferrin receptors, type-1 insulin-like growth factor receptors (IGF1R), and interleukin 4 receptors (IL4R) was measured by flow cytometry analysis on unirradiated cells and on cells 3 to 120 h after irradiation. In Daoy cells, the absolute expression index of transferrin receptors increased during the 24 h after irradiation with the greatest change of 26% above control at 9 h. The absolute expression index of IGF1R increased 26.5% above control at 12 h. The absolute expression index of IL4R decreased 9 h after irradiation. In U373-MG cells the absolute expression index of transferrin receptors increased during the 24 h after irradiation, and the greatest increase was 45% above control at 9 h. The absolute expression index of IGF1R increased during the 12 h after irradiation with a maximum increase of 33% above control at 6 h. The absolute expression index of IL4R decreased with time after irradiation. In T98-G cells, the absolute expression index of both transferrin receptors and IL4R decreased after irradiation. The results suggest that the expression of growth factor receptors on brain tumor cells may be influenced by radiation. The effect of ionizing radiation on receptor expression should be considered when administration of targeted toxin is combined with radiation. Similar studies with other growth factor receptors used in targeted toxin therapy are recommended.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.1667/RR3040</identifier><identifier>PMID: 12859234</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Biological and medical sciences ; Brain neoplasms ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cell lines ; Flow Cytometry - methods ; Gene Expression Regulation, Neoplastic - radiation effects ; Glioblastoma - metabolism ; Glioblastoma - pathology ; Immunotoxins ; Irradiation ; Medical sciences ; Medulloblastoma - metabolism ; Medulloblastoma - pathology ; Neurons ; Receptor, IGF Type 1 - genetics ; Receptor, IGF Type 1 - metabolism ; Receptors ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, Interleukin-4 - genetics ; Receptors, Interleukin-4 - metabolism ; Receptors, Transferrin - genetics ; Receptors, Transferrin - metabolism ; REGULAR PAPERS ; Somatomedins ; Transferrin ; Transferrin receptors ; Tumor cell line ; Tumor Cells, Cultured - metabolism ; Tumor Cells, Cultured - radiation effects ; Tumors</subject><ispartof>Radiation research, 2003-08, Vol.160 (2), p.224-231</ispartof><rights>Radiation Research Society</rights><rights>Copyright 2003 The Radiation Research Society</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b355t-67952cfd9e1217fa3b435d0d1b25aff2e74fe3cc834ea0cb7b9cfdd908a64e463</citedby><cites>FETCH-LOGICAL-b355t-67952cfd9e1217fa3b435d0d1b25aff2e74fe3cc834ea0cb7b9cfdd908a64e463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1667/RR3040$$EPDF$$P50$$Gbioone$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3581171$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,26978,27924,27925,52363,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15020552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12859234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ki-Uk</creatorcontrib><creatorcontrib>Xiao, Jing</creatorcontrib><creatorcontrib>Ni, Hsiao-Tzu</creatorcontrib><creatorcontrib>Cho, Kwan H.</creatorcontrib><creatorcontrib>Spellman, Stephen R.</creatorcontrib><creatorcontrib>Low, Walter C.</creatorcontrib><creatorcontrib>Hall, Walter A.</creatorcontrib><title>Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Kim, K-U., Xiao, J., Ni, H-T., Cho, K. H., Spellman, S. R., Low, W. C. and Hall, W. A. Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines. Radiat. Res. 160, 224–231 (2003). Various immunotoxins have been developed for the treatment of cancer. The toxin is internalized by target cells through cell-surface receptors, and it is essential for these receptors to be expressed for the immunotoxin to have specific anti-tumor activity. Radiation therapy is one of the main treatment modalities for primary malignant brain tumors. The purpose of this study was to determine whether radiation influences the expression of cell-surface receptors. Cells of one human medulloblastoma (Daoy) and two glioblastoma (U373-MG and T98-G) cell lines were tested by exposing the cells to a single dose of 5 Gy γ rays. Expression of transferrin receptors, type-1 insulin-like growth factor receptors (IGF1R), and interleukin 4 receptors (IL4R) was measured by flow cytometry analysis on unirradiated cells and on cells 3 to 120 h after irradiation. In Daoy cells, the absolute expression index of transferrin receptors increased during the 24 h after irradiation with the greatest change of 26% above control at 9 h. The absolute expression index of IGF1R increased 26.5% above control at 12 h. The absolute expression index of IL4R decreased 9 h after irradiation. In U373-MG cells the absolute expression index of transferrin receptors increased during the 24 h after irradiation, and the greatest increase was 45% above control at 9 h. The absolute expression index of IGF1R increased during the 12 h after irradiation with a maximum increase of 33% above control at 6 h. The absolute expression index of IL4R decreased with time after irradiation. In T98-G cells, the absolute expression index of both transferrin receptors and IL4R decreased after irradiation. The results suggest that the expression of growth factor receptors on brain tumor cells may be influenced by radiation. The effect of ionizing radiation on receptor expression should be considered when administration of targeted toxin is combined with radiation. Similar studies with other growth factor receptors used in targeted toxin therapy are recommended.</description><subject>Biological and medical sciences</subject><subject>Brain neoplasms</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell lines</subject><subject>Flow Cytometry - methods</subject><subject>Gene Expression Regulation, Neoplastic - radiation effects</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - pathology</subject><subject>Immunotoxins</subject><subject>Irradiation</subject><subject>Medical sciences</subject><subject>Medulloblastoma - metabolism</subject><subject>Medulloblastoma - pathology</subject><subject>Neurons</subject><subject>Receptor, IGF Type 1 - genetics</subject><subject>Receptor, IGF Type 1 - metabolism</subject><subject>Receptors</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Interleukin-4 - genetics</subject><subject>Receptors, Interleukin-4 - metabolism</subject><subject>Receptors, Transferrin - genetics</subject><subject>Receptors, Transferrin - metabolism</subject><subject>REGULAR PAPERS</subject><subject>Somatomedins</subject><subject>Transferrin</subject><subject>Transferrin receptors</subject><subject>Tumor cell line</subject><subject>Tumor Cells, Cultured - metabolism</subject><subject>Tumor Cells, Cultured - radiation effects</subject><subject>Tumors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMoWm9PIJKFunI0mSRzWWrxUqgopa7LmcyJRqeZkkxRX8jnNGWKrlydnPwfH4efkEPOLniW5ZeTiWCSbZABL0WRKMnkJhkwJkSSqyLfIbshvLG486zcJjs8LVSZCjkg38NXcC8YqHX05nPhMQTbOtoaOvXggkHvrTunIxeWjXVJY9-R3vn2o3ult6C71lN-TsHVkejQN7h8jyJJJ6hxEdNAwcR_OvIeagvd2j3Epgmrx5O3c_Bf9AEa--LAdfTaQzRMl_OoXmF0bB2GfbJloAl4sJ575Pn2Zjq8T8aPd6Ph1TiphFJdkuWlSrWpS-Qpzw2ISgpVs5pXqQJjUsylQaF1ISQC01VelZGuS1ZAJlFmYo-c9V7t2xA8mtmiv3DG2WxV9KwvOoLHPbhYVnOs_7B1sxE4XQMQNDQmtqlt-OMUS5lSaeSOeu4txL5-c6EKznMe45M-rmzbOvzvnB8iAZxR</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Kim, Ki-Uk</creator><creator>Xiao, Jing</creator><creator>Ni, Hsiao-Tzu</creator><creator>Cho, Kwan H.</creator><creator>Spellman, Stephen R.</creator><creator>Low, Walter C.</creator><creator>Hall, Walter A.</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030801</creationdate><title>Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines</title><author>Kim, Ki-Uk ; Xiao, Jing ; Ni, Hsiao-Tzu ; Cho, Kwan H. ; Spellman, Stephen R. ; Low, Walter C. ; Hall, Walter A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b355t-67952cfd9e1217fa3b435d0d1b25aff2e74fe3cc834ea0cb7b9cfdd908a64e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Brain neoplasms</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell lines</topic><topic>Flow Cytometry - methods</topic><topic>Gene Expression Regulation, Neoplastic - radiation effects</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - pathology</topic><topic>Immunotoxins</topic><topic>Irradiation</topic><topic>Medical sciences</topic><topic>Medulloblastoma - metabolism</topic><topic>Medulloblastoma - pathology</topic><topic>Neurons</topic><topic>Receptor, IGF Type 1 - genetics</topic><topic>Receptor, IGF Type 1 - metabolism</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Interleukin-4 - genetics</topic><topic>Receptors, Interleukin-4 - metabolism</topic><topic>Receptors, Transferrin - genetics</topic><topic>Receptors, Transferrin - metabolism</topic><topic>REGULAR PAPERS</topic><topic>Somatomedins</topic><topic>Transferrin</topic><topic>Transferrin receptors</topic><topic>Tumor cell line</topic><topic>Tumor Cells, Cultured - metabolism</topic><topic>Tumor Cells, Cultured - radiation effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ki-Uk</creatorcontrib><creatorcontrib>Xiao, Jing</creatorcontrib><creatorcontrib>Ni, Hsiao-Tzu</creatorcontrib><creatorcontrib>Cho, Kwan H.</creatorcontrib><creatorcontrib>Spellman, Stephen R.</creatorcontrib><creatorcontrib>Low, Walter C.</creatorcontrib><creatorcontrib>Hall, Walter A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ki-Uk</au><au>Xiao, Jing</au><au>Ni, Hsiao-Tzu</au><au>Cho, Kwan H.</au><au>Spellman, Stephen R.</au><au>Low, Walter C.</au><au>Hall, Walter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>160</volume><issue>2</issue><spage>224</spage><epage>231</epage><pages>224-231</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Kim, K-U., Xiao, J., Ni, H-T., Cho, K. H., Spellman, S. R., Low, W. C. and Hall, W. A. Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines. Radiat. Res. 160, 224–231 (2003). Various immunotoxins have been developed for the treatment of cancer. The toxin is internalized by target cells through cell-surface receptors, and it is essential for these receptors to be expressed for the immunotoxin to have specific anti-tumor activity. Radiation therapy is one of the main treatment modalities for primary malignant brain tumors. The purpose of this study was to determine whether radiation influences the expression of cell-surface receptors. Cells of one human medulloblastoma (Daoy) and two glioblastoma (U373-MG and T98-G) cell lines were tested by exposing the cells to a single dose of 5 Gy γ rays. Expression of transferrin receptors, type-1 insulin-like growth factor receptors (IGF1R), and interleukin 4 receptors (IL4R) was measured by flow cytometry analysis on unirradiated cells and on cells 3 to 120 h after irradiation. In Daoy cells, the absolute expression index of transferrin receptors increased during the 24 h after irradiation with the greatest change of 26% above control at 9 h. The absolute expression index of IGF1R increased 26.5% above control at 12 h. The absolute expression index of IL4R decreased 9 h after irradiation. In U373-MG cells the absolute expression index of transferrin receptors increased during the 24 h after irradiation, and the greatest increase was 45% above control at 9 h. The absolute expression index of IGF1R increased during the 12 h after irradiation with a maximum increase of 33% above control at 6 h. The absolute expression index of IL4R decreased with time after irradiation. In T98-G cells, the absolute expression index of both transferrin receptors and IL4R decreased after irradiation. The results suggest that the expression of growth factor receptors on brain tumor cells may be influenced by radiation. The effect of ionizing radiation on receptor expression should be considered when administration of targeted toxin is combined with radiation. Similar studies with other growth factor receptors used in targeted toxin therapy are recommended.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>12859234</pmid><doi>10.1667/RR3040</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 2003-08, Vol.160 (2), p.224-231 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_1667_RR3040 |
| source | MEDLINE; BioOne Complete; JSTOR Archive Collection A-Z Listing |
| subjects | Biological and medical sciences Brain neoplasms Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell lines Flow Cytometry - methods Gene Expression Regulation, Neoplastic - radiation effects Glioblastoma - metabolism Glioblastoma - pathology Immunotoxins Irradiation Medical sciences Medulloblastoma - metabolism Medulloblastoma - pathology Neurons Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Interleukin-4 - genetics Receptors, Interleukin-4 - metabolism Receptors, Transferrin - genetics Receptors, Transferrin - metabolism REGULAR PAPERS Somatomedins Transferrin Transferrin receptors Tumor cell line Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - radiation effects Tumors |
| title | Changes in Expression of Transferrin, Insulin-like Growth Factor 1, and Interleukin 4 Receptors after Irradiation of Cells of Primary Malignant Brain Tumor Cell Lines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T10%3A59%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20Expression%20of%20Transferrin,%20Insulin-like%20Growth%20Factor%201,%20and%20Interleukin%204%20Receptors%20after%20Irradiation%20of%20Cells%20of%20Primary%20Malignant%20Brain%20Tumor%20Cell%20Lines&rft.jtitle=Radiation%20research&rft.au=Kim,%20Ki-Uk&rft.date=2003-08-01&rft.volume=160&rft.issue=2&rft.spage=224&rft.epage=231&rft.pages=224-231&rft.issn=0033-7587&rft.eissn=1938-5404&rft.coden=RAREAE&rft_id=info:doi/10.1667/RR3040&rft_dat=%3Cjstor_cross%3E3581171%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12859234&rft_jstor_id=3581171&rfr_iscdi=true |