Chemotherapy and Radiotherapy for Treatment of Cutaneous Lymphoma in a Ground Cuscus (Phalanger gymnotis)
A 15-year-old female ground cuscus (Phalanger gymnotis) was presented with an isolated ulcerated, nonhealing lesion on the lateral thorax. Histopathology and immunohistochemistry were diagnostic for cutaneous T-cell lymphoma with incomplete excision. Oral chemotherapy with CCNU (lomustine) resulted...
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| Veröffentlicht in: | Journal of zoo and wildlife medicine 2008-09, Vol.39 (3), p.472-475 |
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| container_title | Journal of zoo and wildlife medicine |
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| creator | Goodnight, Andrea L Couto, C. Guillermo Green, Eric Barrie, Michael Myers, Gwen |
| description | A 15-year-old female ground cuscus (Phalanger gymnotis) was presented with an isolated ulcerated, nonhealing lesion on the lateral thorax. Histopathology and immunohistochemistry were diagnostic for cutaneous T-cell lymphoma with incomplete excision. Oral chemotherapy with CCNU (lomustine) resulted in clinical remission that lasted 255 days, with no appreciable toxicity. Tumor recurrence was treated with radiation therapy, which resulted in 120 additional days of clinical remission. Subsequently, the tumor developed at a distant site and the cuscus was humanely euthanized. A slight decrease in appetite early in disease progression was the only adverse effect noted throughout the treatment period. Oral, minimally invasive chemotherapy, and adjunct radiation therapy were viable treatment options for this ground cuscus and should be considered for treatment of neoplasia in other nontraditional species. |
| doi_str_mv | 10.1638/2007-0132.1 |
| format | Article |
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Guillermo</creatorcontrib><creatorcontrib>Green, Eric</creatorcontrib><creatorcontrib>Barrie, Michael</creatorcontrib><creatorcontrib>Myers, Gwen</creatorcontrib><title>Chemotherapy and Radiotherapy for Treatment of Cutaneous Lymphoma in a Ground Cuscus (Phalanger gymnotis)</title><title>Journal of zoo and wildlife medicine</title><addtitle>J Zoo Wildl Med</addtitle><description>A 15-year-old female ground cuscus (Phalanger gymnotis) was presented with an isolated ulcerated, nonhealing lesion on the lateral thorax. Histopathology and immunohistochemistry were diagnostic for cutaneous T-cell lymphoma with incomplete excision. Oral chemotherapy with CCNU (lomustine) resulted in clinical remission that lasted 255 days, with no appreciable toxicity. Tumor recurrence was treated with radiation therapy, which resulted in 120 additional days of clinical remission. Subsequently, the tumor developed at a distant site and the cuscus was humanely euthanized. A slight decrease in appetite early in disease progression was the only adverse effect noted throughout the treatment period. Oral, minimally invasive chemotherapy, and adjunct radiation therapy were viable treatment options for this ground cuscus and should be considered for treatment of neoplasia in other nontraditional species.</description><subject>Animals</subject><subject>Antineoplastic Agents, Alkylating - therapeutic use</subject><subject>Appetite</subject><subject>Biopsies</subject><subject>BRIEF COMMUNICATIONS</subject><subject>CCNU</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>cutaneous lymphoma</subject><subject>Dosage</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>ground cuscus</subject><subject>Lesions</subject><subject>lomustine</subject><subject>Lomustine - therapeutic use</subject><subject>Lymphoma</subject><subject>Lymphoma, T-Cell, Cutaneous - drug therapy</subject><subject>Lymphoma, T-Cell, Cutaneous - radiotherapy</subject><subject>Lymphoma, T-Cell, Cutaneous - veterinary</subject><subject>Neoplasia</subject><subject>Phalanger gymnotis</subject><subject>Phalangeridae</subject><subject>Radiotherapy</subject><subject>Remission Induction - methods</subject><subject>Thoracic Neoplasms - drug therapy</subject><subject>Thoracic Neoplasms - radiotherapy</subject><subject>Thoracic Neoplasms - veterinary</subject><subject>Tumors</subject><subject>Zoos</subject><issn>1042-7260</issn><issn>1937-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1PwzAQxS0EoqUwMYM8UqEU2_mwM6IIClIlEOoeXRK7SdXEke0M-e9xlapsTHe693t3uofQPSUrmoTihRHCA0JDtqIXaE7TkAdMsPjS9yRiAWcJmaEba_eE0ITR6BrNqBCUExrPUZPVstWulgb6EUNX4R-omvNAaYO3RoJrZeewVjgbHHRSDxZvxravdQu46TDgtdGDN2eDLb329F3DAbqdNHg3tp12jV3eoisFByvvTnWBtu9v2-wj2HytP7PXTVCEUeiCJFYpcJ4KkJxLkQpVpbJSUchlXCQsSoUsRakokASUKDjnhbfERepfhlKEC_Q8rS2NttZIlfemacGMOSX5Ma_8mFd-zCunnn6c6H4oWln9saeAPPAwAXvrtDnrjEQJiQnz-nLSi0brTv577BcDlHy6</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Goodnight, Andrea L</creator><creator>Couto, C. 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Guillermo ; Green, Eric ; Barrie, Michael ; Myers, Gwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b343t-65f9a7798ae77e898fd9edf437e5b62498ec8cf1a06af8b777b65f5b9825ac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - therapeutic use</topic><topic>Appetite</topic><topic>Biopsies</topic><topic>BRIEF COMMUNICATIONS</topic><topic>CCNU</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy</topic><topic>cutaneous lymphoma</topic><topic>Dosage</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>ground cuscus</topic><topic>Lesions</topic><topic>lomustine</topic><topic>Lomustine - therapeutic use</topic><topic>Lymphoma</topic><topic>Lymphoma, T-Cell, Cutaneous - drug therapy</topic><topic>Lymphoma, T-Cell, Cutaneous - radiotherapy</topic><topic>Lymphoma, T-Cell, Cutaneous - veterinary</topic><topic>Neoplasia</topic><topic>Phalanger gymnotis</topic><topic>Phalangeridae</topic><topic>Radiotherapy</topic><topic>Remission Induction - methods</topic><topic>Thoracic Neoplasms - drug therapy</topic><topic>Thoracic Neoplasms - radiotherapy</topic><topic>Thoracic Neoplasms - veterinary</topic><topic>Tumors</topic><topic>Zoos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodnight, Andrea L</creatorcontrib><creatorcontrib>Couto, C. Guillermo</creatorcontrib><creatorcontrib>Green, Eric</creatorcontrib><creatorcontrib>Barrie, Michael</creatorcontrib><creatorcontrib>Myers, Gwen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of zoo and wildlife medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodnight, Andrea L</au><au>Couto, C. 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Tumor recurrence was treated with radiation therapy, which resulted in 120 additional days of clinical remission. Subsequently, the tumor developed at a distant site and the cuscus was humanely euthanized. A slight decrease in appetite early in disease progression was the only adverse effect noted throughout the treatment period. Oral, minimally invasive chemotherapy, and adjunct radiation therapy were viable treatment options for this ground cuscus and should be considered for treatment of neoplasia in other nontraditional species.</abstract><cop>United States</cop><pub>American Association of Zoo Veterinarians</pub><pmid>18817015</pmid><doi>10.1638/2007-0132.1</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1042-7260 |
| ispartof | Journal of zoo and wildlife medicine, 2008-09, Vol.39 (3), p.472-475 |
| issn | 1042-7260 1937-2825 |
| language | eng |
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| source | MEDLINE; BioOne Complete; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Antineoplastic Agents, Alkylating - therapeutic use Appetite Biopsies BRIEF COMMUNICATIONS CCNU Chemotherapy Combined Modality Therapy cutaneous lymphoma Dosage Fatal Outcome Female ground cuscus Lesions lomustine Lomustine - therapeutic use Lymphoma Lymphoma, T-Cell, Cutaneous - drug therapy Lymphoma, T-Cell, Cutaneous - radiotherapy Lymphoma, T-Cell, Cutaneous - veterinary Neoplasia Phalanger gymnotis Phalangeridae Radiotherapy Remission Induction - methods Thoracic Neoplasms - drug therapy Thoracic Neoplasms - radiotherapy Thoracic Neoplasms - veterinary Tumors Zoos |
| title | Chemotherapy and Radiotherapy for Treatment of Cutaneous Lymphoma in a Ground Cuscus (Phalanger gymnotis) |
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