Small Peptide Analogue of SDF‐1α Supports Survival of Cord Blood CD34+ Cells in Synergy with Other Cytokines and Enhances Their Ex Vivo Expansion and Engraftment into Nonobese Diabetic/Severe Combined Immunodeficient Mice

The SDF‐1/CXCR4 axis has been implicated in the chemotaxis, homing, mobilization, and expansion of hematopoietic stem and progenitor cells. We studied the effects of a SDF‐1 peptide analogue CTCE‐0214 on the survival of cord blood CD34+ cells in culture, expansion, and engraftment of expanded cells...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2006-01, Vol.24 (1), p.55-64
Hauptverfasser:	Li, Karen, Chuen, Carmen Ka Yee, Lee, Shuk Man, Law, Ping, Fok, Tai Fai, Ng, Pak Cheung, Li, Chi Kong, Wong, Donald, Merzouk, Ahmed, Salari, Hassan, Gu, Goldie Jia‐Shi, Yuen, Patrick Man Pan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cord blood CD34+ cells CXCR4 Engraftment Ex vivo expansion Nonobese diabetic/severe combined immunodeficient mice SDF‐1
Online-Zugang:	Volltext
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