Uric Acid Elevation by Favipiravir, an Antiviral Drug

In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). Increase in blood uric acid level is a frequent side effect of favipiravir. Here...

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Veröffentlicht in:	The Tohoku Journal of Experimental Medicine 2020, Vol.251(2), pp.87-90
Hauptverfasser:	Mishima, Eikan, Anzai, Naohiko, Miyazaki, Mariko, Abe, Takaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Oxidase - metabolism Amides - adverse effects Amides - pharmacokinetics Amides - urine Antiviral Agents - adverse effects Antiviral Agents - pharmacokinetics Biotransformation Coronavirus Infections - drug therapy COVID-19 Drug Interactions favipiravir Humans hyperuricemia Hyperuricemia - chemically induced Hyperuricemia - physiopathology influenza Kidney - metabolism Kidney Diseases - metabolism Molecular Structure Organic Anion Transport Protein 1 - antagonists & inhibitors Organic Anion Transporters - metabolism Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Cation Transport Proteins - metabolism Pandemics Pneumonia, Viral - drug therapy Pyrazines - adverse effects Pyrazines - pharmacokinetics Pyrazines - urine SARS-CoV-2 Uric Acid - blood Xanthine Oxidase - metabolism
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