Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats"....
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| Veröffentlicht in: | Acta cirurgica brasileira 2012-08, Vol.27 (8), p.589-594 |
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| container_end_page | 594 |
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| container_issue | 8 |
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| container_title | Acta cirurgica brasileira |
| container_volume | 27 |
| creator | Marques, Thamirys Guimarães Chaib, Eleazar da Fonseca, Juliana Hamati Lourenço, Ana Cecília Rodrigues Silva, Felipe Duarte Ribeiro, Jr, Marcelo Augusto Fontenelle Galvão, Flavio Henrique Ferreira D'Albuquerque, Luiz Augusto Carneiro |
| description | To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011.
The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery.
For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it. |
| doi_str_mv | 10.1590/s0102-86502012000800013 |
| format | Article |
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This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011.
The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery.
For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/s0102-86502012000800013</identifier><identifier>PMID: 22850713</identifier><language>eng</language><publisher>Brazil</publisher><subject>Animals ; Bile Ducts - surgery ; Carbon Tetrachloride - toxicity ; Ligation ; Liver Cirrhosis, Experimental - chemically induced ; Liver Cirrhosis, Experimental - surgery ; Rats ; Time Factors</subject><ispartof>Acta cirurgica brasileira, 2012-08, Vol.27 (8), p.589-594</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-7a0cceccf604eeceeffac86b5815d5d3af2f2237ad062cb5306dbb98eb3ae883</citedby><cites>FETCH-LOGICAL-c488t-7a0cceccf604eeceeffac86b5815d5d3af2f2237ad062cb5306dbb98eb3ae883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22850713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Thamirys Guimarães</creatorcontrib><creatorcontrib>Chaib, Eleazar</creatorcontrib><creatorcontrib>da Fonseca, Juliana Hamati</creatorcontrib><creatorcontrib>Lourenço, Ana Cecília Rodrigues</creatorcontrib><creatorcontrib>Silva, Felipe Duarte</creatorcontrib><creatorcontrib>Ribeiro, Jr, Marcelo Augusto Fontenelle</creatorcontrib><creatorcontrib>Galvão, Flavio Henrique Ferreira</creatorcontrib><creatorcontrib>D'Albuquerque, Luiz Augusto Carneiro</creatorcontrib><title>Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011.
The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery.
For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.</description><subject>Animals</subject><subject>Bile Ducts - surgery</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>Ligation</subject><subject>Liver Cirrhosis, Experimental - chemically induced</subject><subject>Liver Cirrhosis, Experimental - surgery</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkNtKAzEQhoMotlZfQfMCq5NkN5teSvEEBUF7v-QwaVO2uyXZqn17U6reeDHMwHz_wHyE3DC4ZdUU7hIw4IWSFXBgHABULiZOyJjJWhVc1uUpGf9BI3KR0joTpWTinIw4VxXUTIzJ7g0_An7S3lP82mIMG-wG3dJN77BN1PeRhs7tbOiWdIVbPQRLbYhx1aeQqNlTE1qkGRhoG5Z53XdUd45aHU0eBxyitqu2j8FhvrRGe0AuyZnXbcKrnz4hi8eHxey5mL8-vczu54UtlRqKWoO1aK2XUCJaRO-1VdJUilWuckJ77jkXtXYguTWVAOmMmSo0QqNSYkLq41kb-5Qi-mabH9Rx3zBoDh6b94Oi5p_HnLw-Jrc7s0H3l_sVJ74BWzNyPA</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Marques, Thamirys Guimarães</creator><creator>Chaib, Eleazar</creator><creator>da Fonseca, Juliana Hamati</creator><creator>Lourenço, Ana Cecília Rodrigues</creator><creator>Silva, Felipe Duarte</creator><creator>Ribeiro, Jr, Marcelo Augusto Fontenelle</creator><creator>Galvão, Flavio Henrique Ferreira</creator><creator>D'Albuquerque, Luiz Augusto Carneiro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120801</creationdate><title>Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection</title><author>Marques, Thamirys Guimarães ; Chaib, Eleazar ; da Fonseca, Juliana Hamati ; Lourenço, Ana Cecília Rodrigues ; Silva, Felipe Duarte ; Ribeiro, Jr, Marcelo Augusto Fontenelle ; Galvão, Flavio Henrique Ferreira ; D'Albuquerque, Luiz Augusto Carneiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-7a0cceccf604eeceeffac86b5815d5d3af2f2237ad062cb5306dbb98eb3ae883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bile Ducts - surgery</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>Ligation</topic><topic>Liver Cirrhosis, Experimental - chemically induced</topic><topic>Liver Cirrhosis, Experimental - surgery</topic><topic>Rats</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Thamirys Guimarães</creatorcontrib><creatorcontrib>Chaib, Eleazar</creatorcontrib><creatorcontrib>da Fonseca, Juliana Hamati</creatorcontrib><creatorcontrib>Lourenço, Ana Cecília Rodrigues</creatorcontrib><creatorcontrib>Silva, Felipe Duarte</creatorcontrib><creatorcontrib>Ribeiro, Jr, Marcelo Augusto Fontenelle</creatorcontrib><creatorcontrib>Galvão, Flavio Henrique Ferreira</creatorcontrib><creatorcontrib>D'Albuquerque, Luiz Augusto Carneiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Thamirys Guimarães</au><au>Chaib, Eleazar</au><au>da Fonseca, Juliana Hamati</au><au>Lourenço, Ana Cecília Rodrigues</au><au>Silva, Felipe Duarte</au><au>Ribeiro, Jr, Marcelo Augusto Fontenelle</au><au>Galvão, Flavio Henrique Ferreira</au><au>D'Albuquerque, Luiz Augusto Carneiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>27</volume><issue>8</issue><spage>589</spage><epage>594</epage><pages>589-594</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011.
The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery.
For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.</abstract><cop>Brazil</cop><pmid>22850713</pmid><doi>10.1590/s0102-86502012000800013</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0102-8650 |
| ispartof | Acta cirurgica brasileira, 2012-08, Vol.27 (8), p.589-594 |
| issn | 0102-8650 1678-2674 0102-8650 |
| language | eng |
| recordid | cdi_crossref_primary_10_1590_S0102_86502012000800013 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Bile Ducts - surgery Carbon Tetrachloride - toxicity Ligation Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - surgery Rats Time Factors |
| title | Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection |
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