Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats
To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN). Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From...
Gespeichert in:
| Veröffentlicht in: | Acta cirurgica brasileira 2012-08, Vol.27 (8), p.529-536 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 536 |
|---|---|
| container_issue | 8 |
| container_start_page | 529 |
| container_title | Acta cirurgica brasileira |
| container_volume | 27 |
| creator | Dornelas, Conceição Aparecida Fechine-Jamacaru, Francisco Vagnaldo Albuquerque, Irineu Lima Magalhães, Hemerson Iury Ferreira Dias, Thiago Alves Faria, Mário Henrique Girão Alves, Markênia Kely Santos Rabenhorst, Silvia Helena Barem de Almeida, Paulo Roberto Carvalho Lemos, Telma Leda Gomes de Castro, José Daniel Vieira de Moraes, Maria Elisabete Amaral Moraes, Manoel Odorico |
| description | To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN).
Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software.
The microvascular density in bladder carcinomas was lower (p |
| doi_str_mv | 10.1590/s0102-86502012000800003 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1590_S0102_86502012000800003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>22850703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c364t-e92549bccb70fedb2ebac344ce661c712f547f16be4c2b554d7c070e4189bbe83</originalsourceid><addsrcrecordid>eNplkMtOwzAQRS0EoqXwC-AfCIwdP5JlVfGSKrEA1pHtjFuj1InssOjfk6rQDYvRXcw9I80h5I7BPZM1PGRgwItKSeDAOABU00B5RuZM6argSotzMj-VZuQq5y8AJhQrL8mM80qChnJOwjJuQr_BiDlkGuI22DCGPlK7p5uEGOmQ-qHvpqWJLR23OOWRCI6i9-hG2nu6Lrp9DhHpAe1M22KizkQ3RYg0mTFfkwtvuow3v7kgn0-PH6uXYv32_LpargtXKjEWWHMpauuc1eCxtRytcaUQDpViTjPupdCeKYvCcSulaLWbXkHBqtparMoF0ce7LvU5J_TNkMLOpH3DoDnIa94PXpp_8iby9kgO33aH7Yn7s1X-AEMda-M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Dornelas, Conceição Aparecida ; Fechine-Jamacaru, Francisco Vagnaldo ; Albuquerque, Irineu Lima ; Magalhães, Hemerson Iury Ferreira ; Dias, Thiago Alves ; Faria, Mário Henrique Girão ; Alves, Markênia Kely Santos ; Rabenhorst, Silvia Helena Barem ; de Almeida, Paulo Roberto Carvalho ; Lemos, Telma Leda Gomes de ; Castro, José Daniel Vieira de ; Moraes, Maria Elisabete Amaral ; Moraes, Manoel Odorico</creator><creatorcontrib>Dornelas, Conceição Aparecida ; Fechine-Jamacaru, Francisco Vagnaldo ; Albuquerque, Irineu Lima ; Magalhães, Hemerson Iury Ferreira ; Dias, Thiago Alves ; Faria, Mário Henrique Girão ; Alves, Markênia Kely Santos ; Rabenhorst, Silvia Helena Barem ; de Almeida, Paulo Roberto Carvalho ; Lemos, Telma Leda Gomes de ; Castro, José Daniel Vieira de ; Moraes, Maria Elisabete Amaral ; Moraes, Manoel Odorico</creatorcontrib><description>To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN).
Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software.
The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls.
Water-soluble derivative of propolis inhibits angiogenesis in BBN-induced rat bladder cancer, while L-lysine treatment stimulates angiogenesis if initiated concurrently with BBN.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/s0102-86502012000800003</identifier><identifier>PMID: 22850703</identifier><language>eng</language><publisher>Brazil</publisher><subject>Angiogenesis Inhibitors - therapeutic use ; Animals ; Butylhydroxybutylnitrosamine - therapeutic use ; Carcinoma - drug therapy ; Carcinoma - pathology ; Disease Models, Animal ; Female ; Lysine - therapeutic use ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Pathologic - pathology ; Plant Extracts - therapeutic use ; Propolis - therapeutic use ; Rats ; Rats, Wistar ; Time Factors ; Treatment Outcome ; Urinary Bladder Neoplasms - blood supply ; Urinary Bladder Neoplasms - drug therapy ; Water - chemistry</subject><ispartof>Acta cirurgica brasileira, 2012-08, Vol.27 (8), p.529-536</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-e92549bccb70fedb2ebac344ce661c712f547f16be4c2b554d7c070e4189bbe83</citedby><cites>FETCH-LOGICAL-c364t-e92549bccb70fedb2ebac344ce661c712f547f16be4c2b554d7c070e4189bbe83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22850703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dornelas, Conceição Aparecida</creatorcontrib><creatorcontrib>Fechine-Jamacaru, Francisco Vagnaldo</creatorcontrib><creatorcontrib>Albuquerque, Irineu Lima</creatorcontrib><creatorcontrib>Magalhães, Hemerson Iury Ferreira</creatorcontrib><creatorcontrib>Dias, Thiago Alves</creatorcontrib><creatorcontrib>Faria, Mário Henrique Girão</creatorcontrib><creatorcontrib>Alves, Markênia Kely Santos</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><creatorcontrib>de Almeida, Paulo Roberto Carvalho</creatorcontrib><creatorcontrib>Lemos, Telma Leda Gomes de</creatorcontrib><creatorcontrib>Castro, José Daniel Vieira de</creatorcontrib><creatorcontrib>Moraes, Maria Elisabete Amaral</creatorcontrib><creatorcontrib>Moraes, Manoel Odorico</creatorcontrib><title>Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN).
Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software.
The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls.
Water-soluble derivative of propolis inhibits angiogenesis in BBN-induced rat bladder cancer, while L-lysine treatment stimulates angiogenesis if initiated concurrently with BBN.</description><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Butylhydroxybutylnitrosamine - therapeutic use</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Lysine - therapeutic use</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Propolis - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urinary Bladder Neoplasms - blood supply</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Water - chemistry</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtOwzAQRS0EoqXwC-AfCIwdP5JlVfGSKrEA1pHtjFuj1InssOjfk6rQDYvRXcw9I80h5I7BPZM1PGRgwItKSeDAOABU00B5RuZM6argSotzMj-VZuQq5y8AJhQrL8mM80qChnJOwjJuQr_BiDlkGuI22DCGPlK7p5uEGOmQ-qHvpqWJLR23OOWRCI6i9-hG2nu6Lrp9DhHpAe1M22KizkQ3RYg0mTFfkwtvuow3v7kgn0-PH6uXYv32_LpargtXKjEWWHMpauuc1eCxtRytcaUQDpViTjPupdCeKYvCcSulaLWbXkHBqtparMoF0ce7LvU5J_TNkMLOpH3DoDnIa94PXpp_8iby9kgO33aH7Yn7s1X-AEMda-M</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Dornelas, Conceição Aparecida</creator><creator>Fechine-Jamacaru, Francisco Vagnaldo</creator><creator>Albuquerque, Irineu Lima</creator><creator>Magalhães, Hemerson Iury Ferreira</creator><creator>Dias, Thiago Alves</creator><creator>Faria, Mário Henrique Girão</creator><creator>Alves, Markênia Kely Santos</creator><creator>Rabenhorst, Silvia Helena Barem</creator><creator>de Almeida, Paulo Roberto Carvalho</creator><creator>Lemos, Telma Leda Gomes de</creator><creator>Castro, José Daniel Vieira de</creator><creator>Moraes, Maria Elisabete Amaral</creator><creator>Moraes, Manoel Odorico</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201208</creationdate><title>Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats</title><author>Dornelas, Conceição Aparecida ; Fechine-Jamacaru, Francisco Vagnaldo ; Albuquerque, Irineu Lima ; Magalhães, Hemerson Iury Ferreira ; Dias, Thiago Alves ; Faria, Mário Henrique Girão ; Alves, Markênia Kely Santos ; Rabenhorst, Silvia Helena Barem ; de Almeida, Paulo Roberto Carvalho ; Lemos, Telma Leda Gomes de ; Castro, José Daniel Vieira de ; Moraes, Maria Elisabete Amaral ; Moraes, Manoel Odorico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-e92549bccb70fedb2ebac344ce661c712f547f16be4c2b554d7c070e4189bbe83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Angiogenesis Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Butylhydroxybutylnitrosamine - therapeutic use</topic><topic>Carcinoma - drug therapy</topic><topic>Carcinoma - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Lysine - therapeutic use</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Propolis - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Urinary Bladder Neoplasms - blood supply</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dornelas, Conceição Aparecida</creatorcontrib><creatorcontrib>Fechine-Jamacaru, Francisco Vagnaldo</creatorcontrib><creatorcontrib>Albuquerque, Irineu Lima</creatorcontrib><creatorcontrib>Magalhães, Hemerson Iury Ferreira</creatorcontrib><creatorcontrib>Dias, Thiago Alves</creatorcontrib><creatorcontrib>Faria, Mário Henrique Girão</creatorcontrib><creatorcontrib>Alves, Markênia Kely Santos</creatorcontrib><creatorcontrib>Rabenhorst, Silvia Helena Barem</creatorcontrib><creatorcontrib>de Almeida, Paulo Roberto Carvalho</creatorcontrib><creatorcontrib>Lemos, Telma Leda Gomes de</creatorcontrib><creatorcontrib>Castro, José Daniel Vieira de</creatorcontrib><creatorcontrib>Moraes, Maria Elisabete Amaral</creatorcontrib><creatorcontrib>Moraes, Manoel Odorico</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dornelas, Conceição Aparecida</au><au>Fechine-Jamacaru, Francisco Vagnaldo</au><au>Albuquerque, Irineu Lima</au><au>Magalhães, Hemerson Iury Ferreira</au><au>Dias, Thiago Alves</au><au>Faria, Mário Henrique Girão</au><au>Alves, Markênia Kely Santos</au><au>Rabenhorst, Silvia Helena Barem</au><au>de Almeida, Paulo Roberto Carvalho</au><au>Lemos, Telma Leda Gomes de</au><au>Castro, José Daniel Vieira de</au><au>Moraes, Maria Elisabete Amaral</au><au>Moraes, Manoel Odorico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2012-08</date><risdate>2012</risdate><volume>27</volume><issue>8</issue><spage>529</spage><epage>536</epage><pages>529-536</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN).
Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software.
The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls.
Water-soluble derivative of propolis inhibits angiogenesis in BBN-induced rat bladder cancer, while L-lysine treatment stimulates angiogenesis if initiated concurrently with BBN.</abstract><cop>Brazil</cop><pmid>22850703</pmid><doi>10.1590/s0102-86502012000800003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0102-8650 |
| ispartof | Acta cirurgica brasileira, 2012-08, Vol.27 (8), p.529-536 |
| issn | 0102-8650 1678-2674 0102-8650 |
| language | eng |
| recordid | cdi_crossref_primary_10_1590_S0102_86502012000800003 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Angiogenesis Inhibitors - therapeutic use Animals Butylhydroxybutylnitrosamine - therapeutic use Carcinoma - drug therapy Carcinoma - pathology Disease Models, Animal Female Lysine - therapeutic use Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Plant Extracts - therapeutic use Propolis - therapeutic use Rats Rats, Wistar Time Factors Treatment Outcome Urinary Bladder Neoplasms - blood supply Urinary Bladder Neoplasms - drug therapy Water - chemistry |
| title | Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T12%3A07%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiogenesis%20inhibition%20by%20green%20propolis%20and%20the%20angiogenic%20effect%20of%20L-lysine%20on%20bladder%20cancer%20in%20rats&rft.jtitle=Acta%20cirurgica%20brasileira&rft.au=Dornelas,%20Concei%C3%A7%C3%A3o%20Aparecida&rft.date=2012-08&rft.volume=27&rft.issue=8&rft.spage=529&rft.epage=536&rft.pages=529-536&rft.issn=0102-8650&rft.eissn=1678-2674&rft_id=info:doi/10.1590/s0102-86502012000800003&rft_dat=%3Cpubmed_cross%3E22850703%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/22850703&rfr_iscdi=true |