Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats
To verify the effects of tibolone administration on trabecular and cortical bone of ovariectomized female rats by computed radiography system (CRS). The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did not (OVX), those groups...
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| Veröffentlicht in: | Acta cirurgica brasileira 2012-03, Vol.27 (3), p.217-222 |
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| creator | Carvalho, Ana Carolina Bergmann de Fernandes, Gustavo Vieira Oliveira Lima, Inayá Oliveira, Davi Ferreira de Henriques, Helene Nara Pantaleão, José Augusto Soares Granjeiro, José Mauro Lopes, Ricardo Tadeu Guzmán-Silva, Maria Angélica |
| description | To verify the effects of tibolone administration on trabecular and cortical bone of ovariectomized female rats by computed radiography system (CRS).
The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did not (OVX), those groups were compared to a control group (C) not ovariectomized. Tibolone administration (1mg/day) began thirty days after the ovariectomy and the treatment remained for five months. At last, the animals were euthanized and femurs and tibias collected. Computed radiographies of the bones were obtained and the digital images were used to determine the bone optical density and cortical thickness on every group. All results were statistically evaluated with significance set at P |
| doi_str_mv | 10.1590/s0102-86502012000300003 |
| format | Article |
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The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did not (OVX), those groups were compared to a control group (C) not ovariectomized. Tibolone administration (1mg/day) began thirty days after the ovariectomy and the treatment remained for five months. At last, the animals were euthanized and femurs and tibias collected. Computed radiographies of the bones were obtained and the digital images were used to determine the bone optical density and cortical thickness on every group. All results were statistically evaluated with significance set at P<0.05%.
Tibolone administration was shown to be beneficial only in the densitometric analysis of the femoral head, performing higher optical density compared to OVX. No difference was found in cortical bone thickness.
Ovariectomy caused bone loss in the analyzed regions and tibolone administered in high doses over a long period showed not to be fully beneficial, but preserved bone mass in the femoral head.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/s0102-86502012000300003</identifier><identifier>PMID: 22460251</identifier><language>eng</language><publisher>Brazil</publisher><subject>Animals ; Bone Density - drug effects ; Disease Models, Animal ; Epidemiologic Methods ; Estrogen Receptor Modulators - administration & dosage ; Estrogen Receptor Modulators - adverse effects ; Estrogens - deficiency ; Female ; Femur - diagnostic imaging ; Femur - drug effects ; Femur - pathology ; Image Processing, Computer-Assisted ; Norpregnenes - administration & dosage ; Norpregnenes - adverse effects ; Ovariectomy - adverse effects ; Radiography ; Rats ; Rats, Wistar ; Tibia - diagnostic imaging ; Tibia - drug effects ; Tibia - pathology</subject><ispartof>Acta cirurgica brasileira, 2012-03, Vol.27 (3), p.217-222</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-330357da116c45039af2664a121fa29a66d9589baf443eeac2cb424e1ff3dc813</citedby><cites>FETCH-LOGICAL-c368t-330357da116c45039af2664a121fa29a66d9589baf443eeac2cb424e1ff3dc813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22460251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho, Ana Carolina Bergmann de</creatorcontrib><creatorcontrib>Fernandes, Gustavo Vieira Oliveira</creatorcontrib><creatorcontrib>Lima, Inayá</creatorcontrib><creatorcontrib>Oliveira, Davi Ferreira de</creatorcontrib><creatorcontrib>Henriques, Helene Nara</creatorcontrib><creatorcontrib>Pantaleão, José Augusto Soares</creatorcontrib><creatorcontrib>Granjeiro, José Mauro</creatorcontrib><creatorcontrib>Lopes, Ricardo Tadeu</creatorcontrib><creatorcontrib>Guzmán-Silva, Maria Angélica</creatorcontrib><title>Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To verify the effects of tibolone administration on trabecular and cortical bone of ovariectomized female rats by computed radiography system (CRS).
The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did not (OVX), those groups were compared to a control group (C) not ovariectomized. Tibolone administration (1mg/day) began thirty days after the ovariectomy and the treatment remained for five months. At last, the animals were euthanized and femurs and tibias collected. Computed radiographies of the bones were obtained and the digital images were used to determine the bone optical density and cortical thickness on every group. All results were statistically evaluated with significance set at P<0.05%.
Tibolone administration was shown to be beneficial only in the densitometric analysis of the femoral head, performing higher optical density compared to OVX. No difference was found in cortical bone thickness.
Ovariectomy caused bone loss in the analyzed regions and tibolone administered in high doses over a long period showed not to be fully beneficial, but preserved bone mass in the femoral head.</description><subject>Animals</subject><subject>Bone Density - drug effects</subject><subject>Disease Models, Animal</subject><subject>Epidemiologic Methods</subject><subject>Estrogen Receptor Modulators - administration & dosage</subject><subject>Estrogen Receptor Modulators - adverse effects</subject><subject>Estrogens - deficiency</subject><subject>Female</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - drug effects</subject><subject>Femur - pathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Norpregnenes - administration & dosage</subject><subject>Norpregnenes - adverse effects</subject><subject>Ovariectomy - adverse effects</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tibia - diagnostic imaging</subject><subject>Tibia - drug effects</subject><subject>Tibia - pathology</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtOwzAQRS0EoqXwC-AfCPgVJ1miikelSiyAdTRxxm1QXrIdpPwA301CoRs2M6M7997FIeSGs1seZ-zOM85ElOqYCcYFY0yyeZyQJddJGgmdqFOyPJoW5ML7D8a40lyek4UQSjMR8yX52rS2HrA1SDtL0QfX7bClJdrKVJM8UmhLGqqiq7sWadijg36kXUuDgwLNUIP7sZjOhcpATYvZh59QDxCwpMU4vZp-mG8HZdXtpoL9SP3oAza0aic1-EtyZqH2ePW7V-T98eFt_RxtX5426_ttZKROQyQlk3FSAufaqJjJDKzQWgEX3ILIQOsyi9OsAKuURAQjTKGEQm6tLE3K5Yokh17jOu8d2rx3VQNuzDnLZ7L56wwt_0d2Sl4fkv1QNFgec38o5Teu93b5</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Carvalho, Ana Carolina Bergmann de</creator><creator>Fernandes, Gustavo Vieira Oliveira</creator><creator>Lima, Inayá</creator><creator>Oliveira, Davi Ferreira de</creator><creator>Henriques, Helene Nara</creator><creator>Pantaleão, José Augusto Soares</creator><creator>Granjeiro, José Mauro</creator><creator>Lopes, Ricardo Tadeu</creator><creator>Guzmán-Silva, Maria Angélica</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20120301</creationdate><title>Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats</title><author>Carvalho, Ana Carolina Bergmann de ; Fernandes, Gustavo Vieira Oliveira ; Lima, Inayá ; Oliveira, Davi Ferreira de ; Henriques, Helene Nara ; Pantaleão, José Augusto Soares ; Granjeiro, José Mauro ; Lopes, Ricardo Tadeu ; Guzmán-Silva, Maria Angélica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-330357da116c45039af2664a121fa29a66d9589baf443eeac2cb424e1ff3dc813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bone Density - drug effects</topic><topic>Disease Models, Animal</topic><topic>Epidemiologic Methods</topic><topic>Estrogen Receptor Modulators - administration & dosage</topic><topic>Estrogen Receptor Modulators - adverse effects</topic><topic>Estrogens - deficiency</topic><topic>Female</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - drug effects</topic><topic>Femur - pathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Norpregnenes - administration & dosage</topic><topic>Norpregnenes - adverse effects</topic><topic>Ovariectomy - adverse effects</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tibia - diagnostic imaging</topic><topic>Tibia - drug effects</topic><topic>Tibia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, Ana Carolina Bergmann de</creatorcontrib><creatorcontrib>Fernandes, Gustavo Vieira Oliveira</creatorcontrib><creatorcontrib>Lima, Inayá</creatorcontrib><creatorcontrib>Oliveira, Davi Ferreira de</creatorcontrib><creatorcontrib>Henriques, Helene Nara</creatorcontrib><creatorcontrib>Pantaleão, José Augusto Soares</creatorcontrib><creatorcontrib>Granjeiro, José Mauro</creatorcontrib><creatorcontrib>Lopes, Ricardo Tadeu</creatorcontrib><creatorcontrib>Guzmán-Silva, Maria Angélica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho, Ana Carolina Bergmann de</au><au>Fernandes, Gustavo Vieira Oliveira</au><au>Lima, Inayá</au><au>Oliveira, Davi Ferreira de</au><au>Henriques, Helene Nara</au><au>Pantaleão, José Augusto Soares</au><au>Granjeiro, José Mauro</au><au>Lopes, Ricardo Tadeu</au><au>Guzmán-Silva, Maria Angélica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>27</volume><issue>3</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To verify the effects of tibolone administration on trabecular and cortical bone of ovariectomized female rats by computed radiography system (CRS).
The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did not (OVX), those groups were compared to a control group (C) not ovariectomized. Tibolone administration (1mg/day) began thirty days after the ovariectomy and the treatment remained for five months. At last, the animals were euthanized and femurs and tibias collected. Computed radiographies of the bones were obtained and the digital images were used to determine the bone optical density and cortical thickness on every group. All results were statistically evaluated with significance set at P<0.05%.
Tibolone administration was shown to be beneficial only in the densitometric analysis of the femoral head, performing higher optical density compared to OVX. No difference was found in cortical bone thickness.
Ovariectomy caused bone loss in the analyzed regions and tibolone administered in high doses over a long period showed not to be fully beneficial, but preserved bone mass in the femoral head.</abstract><cop>Brazil</cop><pmid>22460251</pmid><doi>10.1590/s0102-86502012000300003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Bone Density - drug effects Disease Models, Animal Epidemiologic Methods Estrogen Receptor Modulators - administration & dosage Estrogen Receptor Modulators - adverse effects Estrogens - deficiency Female Femur - diagnostic imaging Femur - drug effects Femur - pathology Image Processing, Computer-Assisted Norpregnenes - administration & dosage Norpregnenes - adverse effects Ovariectomy - adverse effects Radiography Rats Rats, Wistar Tibia - diagnostic imaging Tibia - drug effects Tibia - pathology |
| title | Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats |
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