The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits
To investigate the degree of placental permeability in dyslipidemic rabbits and the consequent vascular dysfunction in fetuses of female rabbits with high lipoprotein levels. Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0...
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| Veröffentlicht in: | Acta cirurgica brasileira 2012-01, Vol.27 (1), p.7-12 |
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| container_title | Acta cirurgica brasileira |
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| creator | Frantz, Elemara Menezes, Honório Sampaio Lange, Kellyn Cristine Abegg, Milena Pacheco Correa, Cora Albrecht Zangalli, Leoni Vieira, Jefferson Luís Zettler, Cláudio Galeano |
| description | To investigate the degree of placental permeability in dyslipidemic rabbits and the consequent vascular dysfunction in fetuses of female rabbits with high lipoprotein levels.
Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0.5% cholesterol, and Group 2 (n=10) - control. On day 30, the levels of plasma lipoproteins and triglycerides were analyzed in the mothers, and the presence of collagen was analyzed in the placenta as well as in fetal coronary and aorta. Statistical analyses used the Student's t and the Mann-Whitney tests.
Lipoprotein levels were significantly different (p=0.02 to p |
| doi_str_mv | 10.1590/s0102-86502012000100002 |
| format | Article |
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Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0.5% cholesterol, and Group 2 (n=10) - control. On day 30, the levels of plasma lipoproteins and triglycerides were analyzed in the mothers, and the presence of collagen was analyzed in the placenta as well as in fetal coronary and aorta. Statistical analyses used the Student's t and the Mann-Whitney tests.
Lipoprotein levels were significantly different (p=0.02 to p<0.001) in experimental and control groups. In the hypercholesterolemic group, total cholesterol levels were in average 793 mg/dl; triglycerides were in average 257 mg/dl; HDL-C was 48 mg/dl, and LDL-C was in average 692 mg/dl. The amount of collagen per micrometers square (mµ²) in samples from hypercholesterolemic animals was significantly higher than in the control group.
The study confirmed placental permeability to lipoproteins, shown by increased amounts of collagen in fetal tissues. This alteration results in increased susceptibility to atherosclerosis in adult life, representing a risk factor for the early development of disease, which may appear even in the prenatal period.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/s0102-86502012000100002</identifier><identifier>PMID: 22159432</identifier><language>eng</language><publisher>Brazil</publisher><subject>Age Factors ; Animals ; Arteriosclerosis - etiology ; Cholesterol - blood ; Collagen - analysis ; Disease Models, Animal ; Female ; Fetus ; Hypercholesterolemia - blood ; Lipoproteins - blood ; Maternal-Fetal Exchange ; Permeability ; Placenta - blood supply ; Placenta - pathology ; Pregnancy ; Rabbits ; Triglycerides - blood</subject><ispartof>Acta cirurgica brasileira, 2012-01, Vol.27 (1), p.7-12</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-8b38704629580f8cd508f71ed68c86069b32cfa59b24ad2927271a8fd97972303</citedby><cites>FETCH-LOGICAL-c364t-8b38704629580f8cd508f71ed68c86069b32cfa59b24ad2927271a8fd97972303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22159432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frantz, Elemara</creatorcontrib><creatorcontrib>Menezes, Honório Sampaio</creatorcontrib><creatorcontrib>Lange, Kellyn Cristine</creatorcontrib><creatorcontrib>Abegg, Milena Pacheco</creatorcontrib><creatorcontrib>Correa, Cora Albrecht</creatorcontrib><creatorcontrib>Zangalli, Leoni</creatorcontrib><creatorcontrib>Vieira, Jefferson Luís</creatorcontrib><creatorcontrib>Zettler, Cláudio Galeano</creatorcontrib><title>The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To investigate the degree of placental permeability in dyslipidemic rabbits and the consequent vascular dysfunction in fetuses of female rabbits with high lipoprotein levels.
Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0.5% cholesterol, and Group 2 (n=10) - control. On day 30, the levels of plasma lipoproteins and triglycerides were analyzed in the mothers, and the presence of collagen was analyzed in the placenta as well as in fetal coronary and aorta. Statistical analyses used the Student's t and the Mann-Whitney tests.
Lipoprotein levels were significantly different (p=0.02 to p<0.001) in experimental and control groups. In the hypercholesterolemic group, total cholesterol levels were in average 793 mg/dl; triglycerides were in average 257 mg/dl; HDL-C was 48 mg/dl, and LDL-C was in average 692 mg/dl. The amount of collagen per micrometers square (mµ²) in samples from hypercholesterolemic animals was significantly higher than in the control group.
The study confirmed placental permeability to lipoproteins, shown by increased amounts of collagen in fetal tissues. This alteration results in increased susceptibility to atherosclerosis in adult life, representing a risk factor for the early development of disease, which may appear even in the prenatal period.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Arteriosclerosis - etiology</subject><subject>Cholesterol - blood</subject><subject>Collagen - analysis</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fetus</subject><subject>Hypercholesterolemia - blood</subject><subject>Lipoproteins - blood</subject><subject>Maternal-Fetal Exchange</subject><subject>Permeability</subject><subject>Placenta - blood supply</subject><subject>Placenta - pathology</subject><subject>Pregnancy</subject><subject>Rabbits</subject><subject>Triglycerides - blood</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkLtOAzEQRS0EIiHwC-AfWBiPd_0oUcRLikRBKKhWXq-tLNqXbFPk7zEKpGGaqxmdO8Uh5IbBLas03EVggIUSFSAwBMhrHjwhSyakKlDI8pQsj9CCXMT4malSMH5OFoj5S8lxST62O0ed984mOnk6mOTCaHq6288u2N3Uu5gvOYbO0GmkKeNzb6wbk6FmbKl3KeMmZKpzkXYjDaZpuhQvyZk3fXRXv7ki748P2_VzsXl9elnfbwrLRZkK1XAloRSoKwVe2bYC5SVzrVBWCRC64Wi9qXSDpWlRo0TJjPKtlloiB74i8vDXhinG4Hw9h24wYV8zqH9k1W8_Hup_snLz-tCcv5rBtcfenx3-DeWOZJ8</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Frantz, Elemara</creator><creator>Menezes, Honório Sampaio</creator><creator>Lange, Kellyn Cristine</creator><creator>Abegg, Milena Pacheco</creator><creator>Correa, Cora Albrecht</creator><creator>Zangalli, Leoni</creator><creator>Vieira, Jefferson Luís</creator><creator>Zettler, Cláudio Galeano</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201201</creationdate><title>The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits</title><author>Frantz, Elemara ; Menezes, Honório Sampaio ; Lange, Kellyn Cristine ; Abegg, Milena Pacheco ; Correa, Cora Albrecht ; Zangalli, Leoni ; Vieira, Jefferson Luís ; Zettler, Cláudio Galeano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-8b38704629580f8cd508f71ed68c86069b32cfa59b24ad2927271a8fd97972303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Arteriosclerosis - etiology</topic><topic>Cholesterol - blood</topic><topic>Collagen - analysis</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fetus</topic><topic>Hypercholesterolemia - blood</topic><topic>Lipoproteins - blood</topic><topic>Maternal-Fetal Exchange</topic><topic>Permeability</topic><topic>Placenta - blood supply</topic><topic>Placenta - pathology</topic><topic>Pregnancy</topic><topic>Rabbits</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frantz, Elemara</creatorcontrib><creatorcontrib>Menezes, Honório Sampaio</creatorcontrib><creatorcontrib>Lange, Kellyn Cristine</creatorcontrib><creatorcontrib>Abegg, Milena Pacheco</creatorcontrib><creatorcontrib>Correa, Cora Albrecht</creatorcontrib><creatorcontrib>Zangalli, Leoni</creatorcontrib><creatorcontrib>Vieira, Jefferson Luís</creatorcontrib><creatorcontrib>Zettler, Cláudio Galeano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frantz, Elemara</au><au>Menezes, Honório Sampaio</au><au>Lange, Kellyn Cristine</au><au>Abegg, Milena Pacheco</au><au>Correa, Cora Albrecht</au><au>Zangalli, Leoni</au><au>Vieira, Jefferson Luís</au><au>Zettler, Cláudio Galeano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2012-01</date><risdate>2012</risdate><volume>27</volume><issue>1</issue><spage>7</spage><epage>12</epage><pages>7-12</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To investigate the degree of placental permeability in dyslipidemic rabbits and the consequent vascular dysfunction in fetuses of female rabbits with high lipoprotein levels.
Fifteen adult females New Zealand White rabbits were divided into two groups. Group 1(n=5) - hypercholesterolemic diet with 0.5% cholesterol, and Group 2 (n=10) - control. On day 30, the levels of plasma lipoproteins and triglycerides were analyzed in the mothers, and the presence of collagen was analyzed in the placenta as well as in fetal coronary and aorta. Statistical analyses used the Student's t and the Mann-Whitney tests.
Lipoprotein levels were significantly different (p=0.02 to p<0.001) in experimental and control groups. In the hypercholesterolemic group, total cholesterol levels were in average 793 mg/dl; triglycerides were in average 257 mg/dl; HDL-C was 48 mg/dl, and LDL-C was in average 692 mg/dl. The amount of collagen per micrometers square (mµ²) in samples from hypercholesterolemic animals was significantly higher than in the control group.
The study confirmed placental permeability to lipoproteins, shown by increased amounts of collagen in fetal tissues. This alteration results in increased susceptibility to atherosclerosis in adult life, representing a risk factor for the early development of disease, which may appear even in the prenatal period.</abstract><cop>Brazil</cop><pmid>22159432</pmid><doi>10.1590/s0102-86502012000100002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Animals Arteriosclerosis - etiology Cholesterol - blood Collagen - analysis Disease Models, Animal Female Fetus Hypercholesterolemia - blood Lipoproteins - blood Maternal-Fetal Exchange Permeability Placenta - blood supply Placenta - pathology Pregnancy Rabbits Triglycerides - blood |
| title | The effect of maternal hypercholesterolemia on the placenta and fetal arteries in rabbits |
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