Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis
Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract. 29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Unc...
Gespeichert in:
| Veröffentlicht in: | Acta cirurgica brasileira 2011, Vol.26 Suppl 2 (suppl 2), p.15-19 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 19 |
|---|---|
| container_issue | suppl 2 |
| container_start_page | 15 |
| container_title | Acta cirurgica brasileira |
| container_volume | 26 Suppl 2 |
| creator | Nogueira Neto, João Cavalcante, Frederico Lucas Lima Paiva Carvalho, Rafael Antonio Freire Rodrigues, Taciana Gabrielle Pinheiro de Moura Xavier, Mariana Santana Furtado, Pablo Gustavo Ribeiro Schor, Eduardo |
| description | Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract.
29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Uncaria tomentosa extract, 1 ml administered daily and the placebo group received 1 ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis.
The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group.
The findings suggest that Uncaria tomentosa has contraceptive effect. |
| doi_str_mv | 10.1590/S0102-86502011000800004 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1590_S0102_86502011000800004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>22030809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-712da2ddd93d2f40889c1846831f0167ddba49ce4bbf08c79cb33eae0805cdea3</originalsourceid><addsrcrecordid>eNplkMtOwzAQRS0EoqXwC-AdsAiMH02cJap4SZVYQLdEjj0WRm0S2YbC3-NSYMNiNJt7RnMPIScMLti0hstHYMALVU6BA2MAoPKA3CFjVlaq4GUld8n4LzQiBzG-AjBZMrFPRpyDyEg9Js-zvktBGxySf0eKzqFJtHd00RkdvKapX2GX-qjpmdHpNFKz1Otz6jsadIp07dMLxY8Bg9_k9JJiZzOSgu-jj4dkz-llxKOfPSGLm-un2V0xf7i9n13NC8NrlYqKcau5tbYWljsJStWGKVkqwRzkRta2WtYGZds6UKaqTSsEaswdpsaiFhNSbe-a0McY0DVDfkiHz4ZBszHWfBtr_hnL5PGWHN7aFdo_7leR-ALfo2gr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nogueira Neto, João ; Cavalcante, Frederico Lucas Lima Paiva ; Carvalho, Rafael Antonio Freire ; Rodrigues, Taciana Gabrielle Pinheiro de Moura ; Xavier, Mariana Santana ; Furtado, Pablo Gustavo Ribeiro ; Schor, Eduardo</creator><creatorcontrib>Nogueira Neto, João ; Cavalcante, Frederico Lucas Lima Paiva ; Carvalho, Rafael Antonio Freire ; Rodrigues, Taciana Gabrielle Pinheiro de Moura ; Xavier, Mariana Santana ; Furtado, Pablo Gustavo Ribeiro ; Schor, Eduardo</creatorcontrib><description>Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract.
29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Uncaria tomentosa extract, 1 ml administered daily and the placebo group received 1 ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis.
The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group.
The findings suggest that Uncaria tomentosa has contraceptive effect.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-86502011000800004</identifier><identifier>PMID: 22030809</identifier><language>eng</language><publisher>Brazil</publisher><subject>Animals ; Cat's Claw - chemistry ; Contraceptive Agents - therapeutic use ; Disease Models, Animal ; Endometriosis - drug therapy ; Endometriosis - pathology ; Female ; Phytotherapy ; Plant Extracts - therapeutic use ; Random Allocation ; Rats ; Rats, Wistar ; Treatment Outcome ; Uterus - drug effects ; Uterus - pathology</subject><ispartof>Acta cirurgica brasileira, 2011, Vol.26 Suppl 2 (suppl 2), p.15-19</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c298t-712da2ddd93d2f40889c1846831f0167ddba49ce4bbf08c79cb33eae0805cdea3</citedby><cites>FETCH-LOGICAL-c298t-712da2ddd93d2f40889c1846831f0167ddba49ce4bbf08c79cb33eae0805cdea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22030809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nogueira Neto, João</creatorcontrib><creatorcontrib>Cavalcante, Frederico Lucas Lima Paiva</creatorcontrib><creatorcontrib>Carvalho, Rafael Antonio Freire</creatorcontrib><creatorcontrib>Rodrigues, Taciana Gabrielle Pinheiro de Moura</creatorcontrib><creatorcontrib>Xavier, Mariana Santana</creatorcontrib><creatorcontrib>Furtado, Pablo Gustavo Ribeiro</creatorcontrib><creatorcontrib>Schor, Eduardo</creatorcontrib><title>Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract.
29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Uncaria tomentosa extract, 1 ml administered daily and the placebo group received 1 ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis.
The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group.
The findings suggest that Uncaria tomentosa has contraceptive effect.</description><subject>Animals</subject><subject>Cat's Claw - chemistry</subject><subject>Contraceptive Agents - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Endometriosis - drug therapy</subject><subject>Endometriosis - pathology</subject><subject>Female</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Treatment Outcome</subject><subject>Uterus - drug effects</subject><subject>Uterus - pathology</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtOwzAQRS0EoqXwC-AdsAiMH02cJap4SZVYQLdEjj0WRm0S2YbC3-NSYMNiNJt7RnMPIScMLti0hstHYMALVU6BA2MAoPKA3CFjVlaq4GUld8n4LzQiBzG-AjBZMrFPRpyDyEg9Js-zvktBGxySf0eKzqFJtHd00RkdvKapX2GX-qjpmdHpNFKz1Otz6jsadIp07dMLxY8Bg9_k9JJiZzOSgu-jj4dkz-llxKOfPSGLm-un2V0xf7i9n13NC8NrlYqKcau5tbYWljsJStWGKVkqwRzkRta2WtYGZds6UKaqTSsEaswdpsaiFhNSbe-a0McY0DVDfkiHz4ZBszHWfBtr_hnL5PGWHN7aFdo_7leR-ALfo2gr</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Nogueira Neto, João</creator><creator>Cavalcante, Frederico Lucas Lima Paiva</creator><creator>Carvalho, Rafael Antonio Freire</creator><creator>Rodrigues, Taciana Gabrielle Pinheiro de Moura</creator><creator>Xavier, Mariana Santana</creator><creator>Furtado, Pablo Gustavo Ribeiro</creator><creator>Schor, Eduardo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2011</creationdate><title>Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis</title><author>Nogueira Neto, João ; Cavalcante, Frederico Lucas Lima Paiva ; Carvalho, Rafael Antonio Freire ; Rodrigues, Taciana Gabrielle Pinheiro de Moura ; Xavier, Mariana Santana ; Furtado, Pablo Gustavo Ribeiro ; Schor, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-712da2ddd93d2f40889c1846831f0167ddba49ce4bbf08c79cb33eae0805cdea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Cat's Claw - chemistry</topic><topic>Contraceptive Agents - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Endometriosis - drug therapy</topic><topic>Endometriosis - pathology</topic><topic>Female</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Treatment Outcome</topic><topic>Uterus - drug effects</topic><topic>Uterus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nogueira Neto, João</creatorcontrib><creatorcontrib>Cavalcante, Frederico Lucas Lima Paiva</creatorcontrib><creatorcontrib>Carvalho, Rafael Antonio Freire</creatorcontrib><creatorcontrib>Rodrigues, Taciana Gabrielle Pinheiro de Moura</creatorcontrib><creatorcontrib>Xavier, Mariana Santana</creatorcontrib><creatorcontrib>Furtado, Pablo Gustavo Ribeiro</creatorcontrib><creatorcontrib>Schor, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nogueira Neto, João</au><au>Cavalcante, Frederico Lucas Lima Paiva</au><au>Carvalho, Rafael Antonio Freire</au><au>Rodrigues, Taciana Gabrielle Pinheiro de Moura</au><au>Xavier, Mariana Santana</au><au>Furtado, Pablo Gustavo Ribeiro</au><au>Schor, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2011</date><risdate>2011</risdate><volume>26 Suppl 2</volume><issue>suppl 2</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>Evaluate the histological changes in parenchyma's epithelial layer of the uterus and ovarian of rats with induced endometriosis, treated with Uncaria tomentosa extract.
29 rats with experimental endometriosis, were selected and divided in three groups: The uncaria group received 32 mg/ml of Uncaria tomentosa extract, 1 ml administered daily and the placebo group received 1 ml of saline 0.9% per day, during for 14 days (both groups); the leuprolide group received leuprolide acetate 1mg/kg body weight applied single subcutaneous dose. In the 15th day of treatment the uterine horn and ovaries were removed for histopathological analysis.
The uncaria group presented nine samples (90%) with immature ovarian follicles, whereas the placebo group did not present any case and in the leuprolide group there were eight rats (88%) with the same change. The placebo group showed mature corpus luteum in all animals, occurring less frequent in uncaria (10%) and leuprolide (22%) groups. The uterine epithelium showed weak proliferative in nine (90%) samples of the uncaria group, in two (20%) animals in the placebo group and seven (77.8%) rats in the leuprolide group.
The findings suggest that Uncaria tomentosa has contraceptive effect.</abstract><cop>Brazil</cop><pmid>22030809</pmid><doi>10.1590/S0102-86502011000800004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0102-8650 |
| ispartof | Acta cirurgica brasileira, 2011, Vol.26 Suppl 2 (suppl 2), p.15-19 |
| issn | 0102-8650 1678-2674 0102-8650 |
| language | eng |
| recordid | cdi_crossref_primary_10_1590_S0102_86502011000800004 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cat's Claw - chemistry Contraceptive Agents - therapeutic use Disease Models, Animal Endometriosis - drug therapy Endometriosis - pathology Female Phytotherapy Plant Extracts - therapeutic use Random Allocation Rats Rats, Wistar Treatment Outcome Uterus - drug effects Uterus - pathology |
| title | Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T03%3A57%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Contraceptive%20effect%20of%20Uncaria%20tomentosa%20(cat's%20claw)%20in%20rats%20with%20experimental%20endometriosis&rft.jtitle=Acta%20cirurgica%20brasileira&rft.au=Nogueira%20Neto,%20Jo%C3%A3o&rft.date=2011&rft.volume=26%20Suppl%202&rft.issue=suppl%202&rft.spage=15&rft.epage=19&rft.pages=15-19&rft.issn=0102-8650&rft.eissn=1678-2674&rft_id=info:doi/10.1590/S0102-86502011000800004&rft_dat=%3Cpubmed_cross%3E22030809%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/22030809&rfr_iscdi=true |