Small bowel transplantation in outbred rats
To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats. Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transpla...
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| Veröffentlicht in: | Acta cirurgica brasileira 2011-12, Vol.26 (6), p.496-502 |
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| creator | Waisberg, Daniel Reis Lee, André Dong Wong Santos, Rafael Miyashiro Nunes dos Mory, Eduardo Kenji Costa, Anderson Lino Montero, Edna Frasson de Souza Chaib, Eleazar D'Albuquerque, Luis Augusto Carneiro Galvao, Flavio Henrique Ferreira |
| description | To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats.
Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transplanted into the recipient using end-to-side aortic and portacaval microvascular anastomosis. Procedure duration, animal clinical course and survival were evaluated. Survival shorter than four days was considered technical failure. Recipients were sacrificed with signs of severe graft rejection or survival longer than 120 days. Necropsies were performed in all recipients to access histopathological changes in the graft.
Median time for the procedure was 107 minutes. Six recipients (16.7%) presented technical failure. Twenty-seven recipients were sacrificed due to rejection, being nineteen (52.7%) between 7(th) and 15(th) postoperative day and eight (22.2%) between 34(th) and 47(th) postoperative day. Graft histology confirmed severe acute cellular rejection in those recipients. Uneventful evolution and survival longer than 120 days without rejection were observed in three recipients (8.3%).
Intestinal transplantation in outbred rats without immunosuppressant regiment accomplishes variable clinical evolution. |
| doi_str_mv | 10.1590/S0102-86502011000600015 |
| format | Article |
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Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transplanted into the recipient using end-to-side aortic and portacaval microvascular anastomosis. Procedure duration, animal clinical course and survival were evaluated. Survival shorter than four days was considered technical failure. Recipients were sacrificed with signs of severe graft rejection or survival longer than 120 days. Necropsies were performed in all recipients to access histopathological changes in the graft.
Median time for the procedure was 107 minutes. Six recipients (16.7%) presented technical failure. Twenty-seven recipients were sacrificed due to rejection, being nineteen (52.7%) between 7(th) and 15(th) postoperative day and eight (22.2%) between 34(th) and 47(th) postoperative day. Graft histology confirmed severe acute cellular rejection in those recipients. Uneventful evolution and survival longer than 120 days without rejection were observed in three recipients (8.3%).
Intestinal transplantation in outbred rats without immunosuppressant regiment accomplishes variable clinical evolution.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-86502011000600015</identifier><identifier>PMID: 22042114</identifier><language>eng</language><publisher>Brazil</publisher><subject>Acute Disease ; Animals ; Graft Rejection - mortality ; Graft Rejection - pathology ; Intestine, Small - pathology ; Intestine, Small - transplantation ; Male ; Models, Animal ; Rats ; Rats, Wistar - classification ; Severity of Illness Index ; Time Factors</subject><ispartof>Acta cirurgica brasileira, 2011-12, Vol.26 (6), p.496-502</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c298t-ceb380dceb4305414f3e20e9d78b44d51e574a7072cd181506ed50367eea6e373</citedby><cites>FETCH-LOGICAL-c298t-ceb380dceb4305414f3e20e9d78b44d51e574a7072cd181506ed50367eea6e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22042114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waisberg, Daniel Reis</creatorcontrib><creatorcontrib>Lee, André Dong Wong</creatorcontrib><creatorcontrib>Santos, Rafael Miyashiro Nunes dos</creatorcontrib><creatorcontrib>Mory, Eduardo Kenji</creatorcontrib><creatorcontrib>Costa, Anderson Lino</creatorcontrib><creatorcontrib>Montero, Edna Frasson de Souza</creatorcontrib><creatorcontrib>Chaib, Eleazar</creatorcontrib><creatorcontrib>D'Albuquerque, Luis Augusto Carneiro</creatorcontrib><creatorcontrib>Galvao, Flavio Henrique Ferreira</creatorcontrib><title>Small bowel transplantation in outbred rats</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats.
Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transplanted into the recipient using end-to-side aortic and portacaval microvascular anastomosis. Procedure duration, animal clinical course and survival were evaluated. Survival shorter than four days was considered technical failure. Recipients were sacrificed with signs of severe graft rejection or survival longer than 120 days. Necropsies were performed in all recipients to access histopathological changes in the graft.
Median time for the procedure was 107 minutes. Six recipients (16.7%) presented technical failure. Twenty-seven recipients were sacrificed due to rejection, being nineteen (52.7%) between 7(th) and 15(th) postoperative day and eight (22.2%) between 34(th) and 47(th) postoperative day. Graft histology confirmed severe acute cellular rejection in those recipients. Uneventful evolution and survival longer than 120 days without rejection were observed in three recipients (8.3%).
Intestinal transplantation in outbred rats without immunosuppressant regiment accomplishes variable clinical evolution.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Graft Rejection - mortality</subject><subject>Graft Rejection - pathology</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - transplantation</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Rats</subject><subject>Rats, Wistar - classification</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplj0tLw0AUhQdRbK3-Bc1eovfOO0spvqDgoroOk8wNRPJiZor4741Wu3FxOJvzHfgYu0K4QVXA7RYQeG61Ag6IAKDnoDpiS9TG5lwbecyWh9GCncX4Pi-kRnHKFpyD5Ihyya63veu6rBo_qMtScEOcOjckl9pxyNohG3epCuSz4FI8ZyeN6yJd_PaKvT3cv66f8s3L4_P6bpPXvLApr6kSFvxcUoCSKBtBHKjwxlZSeoWkjHQGDK89WlSgySsQ2hA5TcKIFTP73zqMMQZqyim0vQufJUL5rV_-6Jf_9Gfyck9Ou6onf-D-fMUXHmZUTg</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Waisberg, Daniel Reis</creator><creator>Lee, André Dong Wong</creator><creator>Santos, Rafael Miyashiro Nunes dos</creator><creator>Mory, Eduardo Kenji</creator><creator>Costa, Anderson Lino</creator><creator>Montero, Edna Frasson de Souza</creator><creator>Chaib, Eleazar</creator><creator>D'Albuquerque, Luis Augusto Carneiro</creator><creator>Galvao, Flavio Henrique Ferreira</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20111201</creationdate><title>Small bowel transplantation in outbred rats</title><author>Waisberg, Daniel Reis ; Lee, André Dong Wong ; Santos, Rafael Miyashiro Nunes dos ; Mory, Eduardo Kenji ; Costa, Anderson Lino ; Montero, Edna Frasson de Souza ; Chaib, Eleazar ; D'Albuquerque, Luis Augusto Carneiro ; Galvao, Flavio Henrique Ferreira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-ceb380dceb4305414f3e20e9d78b44d51e574a7072cd181506ed50367eea6e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Graft Rejection - mortality</topic><topic>Graft Rejection - pathology</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - transplantation</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Rats</topic><topic>Rats, Wistar - classification</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waisberg, Daniel Reis</creatorcontrib><creatorcontrib>Lee, André Dong Wong</creatorcontrib><creatorcontrib>Santos, Rafael Miyashiro Nunes dos</creatorcontrib><creatorcontrib>Mory, Eduardo Kenji</creatorcontrib><creatorcontrib>Costa, Anderson Lino</creatorcontrib><creatorcontrib>Montero, Edna Frasson de Souza</creatorcontrib><creatorcontrib>Chaib, Eleazar</creatorcontrib><creatorcontrib>D'Albuquerque, Luis Augusto Carneiro</creatorcontrib><creatorcontrib>Galvao, Flavio Henrique Ferreira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waisberg, Daniel Reis</au><au>Lee, André Dong Wong</au><au>Santos, Rafael Miyashiro Nunes dos</au><au>Mory, Eduardo Kenji</au><au>Costa, Anderson Lino</au><au>Montero, Edna Frasson de Souza</au><au>Chaib, Eleazar</au><au>D'Albuquerque, Luis Augusto Carneiro</au><au>Galvao, Flavio Henrique Ferreira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small bowel transplantation in outbred rats</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>26</volume><issue>6</issue><spage>496</spage><epage>502</epage><pages>496-502</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To investigate the clinical evolution of orthotopic small bowel transplantation in outbred rats.
Seventy-two outbred Wistar rats weighting from 250 to 300g were used as donor and recipient in 36 consecutives ortothopic small intestine transplantation without immunosuppression. The graft was transplanted into the recipient using end-to-side aortic and portacaval microvascular anastomosis. Procedure duration, animal clinical course and survival were evaluated. Survival shorter than four days was considered technical failure. Recipients were sacrificed with signs of severe graft rejection or survival longer than 120 days. Necropsies were performed in all recipients to access histopathological changes in the graft.
Median time for the procedure was 107 minutes. Six recipients (16.7%) presented technical failure. Twenty-seven recipients were sacrificed due to rejection, being nineteen (52.7%) between 7(th) and 15(th) postoperative day and eight (22.2%) between 34(th) and 47(th) postoperative day. Graft histology confirmed severe acute cellular rejection in those recipients. Uneventful evolution and survival longer than 120 days without rejection were observed in three recipients (8.3%).
Intestinal transplantation in outbred rats without immunosuppressant regiment accomplishes variable clinical evolution.</abstract><cop>Brazil</cop><pmid>22042114</pmid><doi>10.1590/S0102-86502011000600015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta cirurgica brasileira, 2011-12, Vol.26 (6), p.496-502 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Animals Graft Rejection - mortality Graft Rejection - pathology Intestine, Small - pathology Intestine, Small - transplantation Male Models, Animal Rats Rats, Wistar - classification Severity of Illness Index Time Factors |
| title | Small bowel transplantation in outbred rats |
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