Tracheal suture in rats with hypothyroidism: wound healing study
To evaluate the influence of hypothyroidism in tracheal wound healing process. A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture...
Gespeichert in:
| Veröffentlicht in: | Acta cirurgica brasileira 2009-07, Vol.24 (4), p.282-289 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 289 |
|---|---|
| container_issue | 4 |
| container_start_page | 282 |
| container_title | Acta cirurgica brasileira |
| container_volume | 24 |
| creator | Zimmermann, Elise Ribas-Filho, Jurandir Marcondes Malafaia, Osvaldo Ribas, Carmen Austrália Paredes Marcondes Nassif, Paulo Afonso Nunes Stieven Filho, Edmar Przysiezny, Paulo Eduardo |
| description | To evaluate the influence of hypothyroidism in tracheal wound healing process.
A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done.
The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant.
Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity. |
| doi_str_mv | 10.1590/S0102-86502009000400007 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1590_S0102_86502009000400007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19705026</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-d48fc6674a0301d58a0df2c707528501b6a2c911a0e082013fbff3ee7bc14ff83</originalsourceid><addsrcrecordid>eNplkMtOwzAQRS0EoqHwC-AfCMzYie2wAlXlIVViQVlHjh8kqG0qO1GVvyelFSxYXM3mntHVIeQG4RbzAu7eAYGlSuTAAAoAyMaAPCEJCqlSJmR2SpLf0oRcxPgFgJlAfk4mWEgYUZGQh2XQpnZ6RWPf9cHRZkOD7iLdNV1N62HbdvUQ2sY2cX1Pd22_sXRfbzafNHa9HS7Jmder6K6Od0o-nubL2Uu6eHt-nT0uUsOF6lKbKW_EOEsDB7S50mA9MxJkzlQOWAnNTIGowYFigNxX3nPnZGUw817xKZGHvya0MQbny21o1joMJUK5d1L-OCn_ORnJ6wO57au1s3_cUQL_BjlQXKs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Tracheal suture in rats with hypothyroidism: wound healing study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Zimmermann, Elise ; Ribas-Filho, Jurandir Marcondes ; Malafaia, Osvaldo ; Ribas, Carmen Austrália Paredes Marcondes ; Nassif, Paulo Afonso Nunes ; Stieven Filho, Edmar ; Przysiezny, Paulo Eduardo</creator><creatorcontrib>Zimmermann, Elise ; Ribas-Filho, Jurandir Marcondes ; Malafaia, Osvaldo ; Ribas, Carmen Austrália Paredes Marcondes ; Nassif, Paulo Afonso Nunes ; Stieven Filho, Edmar ; Przysiezny, Paulo Eduardo</creatorcontrib><description>To evaluate the influence of hypothyroidism in tracheal wound healing process.
A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done.
The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant.
Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-86502009000400007</identifier><identifier>PMID: 19705026</identifier><language>eng</language><publisher>Brazil</publisher><subject>Animals ; Collagen - biosynthesis ; Coloring Agents ; Disease Models, Animal ; Eosine Yellowish-(YS) ; Fluorescent Dyes ; Hematoxylin ; Hypothyroidism - physiopathology ; Inflammation - pathology ; Male ; Microscopy - methods ; Rats ; Rats, Wistar ; Suture Techniques ; Trachea - surgery ; Wound Healing - physiology</subject><ispartof>Acta cirurgica brasileira, 2009-07, Vol.24 (4), p.282-289</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d48fc6674a0301d58a0df2c707528501b6a2c911a0e082013fbff3ee7bc14ff83</citedby><cites>FETCH-LOGICAL-c368t-d48fc6674a0301d58a0df2c707528501b6a2c911a0e082013fbff3ee7bc14ff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19705026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmermann, Elise</creatorcontrib><creatorcontrib>Ribas-Filho, Jurandir Marcondes</creatorcontrib><creatorcontrib>Malafaia, Osvaldo</creatorcontrib><creatorcontrib>Ribas, Carmen Austrália Paredes Marcondes</creatorcontrib><creatorcontrib>Nassif, Paulo Afonso Nunes</creatorcontrib><creatorcontrib>Stieven Filho, Edmar</creatorcontrib><creatorcontrib>Przysiezny, Paulo Eduardo</creatorcontrib><title>Tracheal suture in rats with hypothyroidism: wound healing study</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>To evaluate the influence of hypothyroidism in tracheal wound healing process.
A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done.
The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant.
Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity.</description><subject>Animals</subject><subject>Collagen - biosynthesis</subject><subject>Coloring Agents</subject><subject>Disease Models, Animal</subject><subject>Eosine Yellowish-(YS)</subject><subject>Fluorescent Dyes</subject><subject>Hematoxylin</subject><subject>Hypothyroidism - physiopathology</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Microscopy - methods</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Suture Techniques</subject><subject>Trachea - surgery</subject><subject>Wound Healing - physiology</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtOwzAQRS0EoqHwC-AfCMzYie2wAlXlIVViQVlHjh8kqG0qO1GVvyelFSxYXM3mntHVIeQG4RbzAu7eAYGlSuTAAAoAyMaAPCEJCqlSJmR2SpLf0oRcxPgFgJlAfk4mWEgYUZGQh2XQpnZ6RWPf9cHRZkOD7iLdNV1N62HbdvUQ2sY2cX1Pd22_sXRfbzafNHa9HS7Jmder6K6Od0o-nubL2Uu6eHt-nT0uUsOF6lKbKW_EOEsDB7S50mA9MxJkzlQOWAnNTIGowYFigNxX3nPnZGUw817xKZGHvya0MQbny21o1joMJUK5d1L-OCn_ORnJ6wO57au1s3_cUQL_BjlQXKs</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Zimmermann, Elise</creator><creator>Ribas-Filho, Jurandir Marcondes</creator><creator>Malafaia, Osvaldo</creator><creator>Ribas, Carmen Austrália Paredes Marcondes</creator><creator>Nassif, Paulo Afonso Nunes</creator><creator>Stieven Filho, Edmar</creator><creator>Przysiezny, Paulo Eduardo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090701</creationdate><title>Tracheal suture in rats with hypothyroidism: wound healing study</title><author>Zimmermann, Elise ; Ribas-Filho, Jurandir Marcondes ; Malafaia, Osvaldo ; Ribas, Carmen Austrália Paredes Marcondes ; Nassif, Paulo Afonso Nunes ; Stieven Filho, Edmar ; Przysiezny, Paulo Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d48fc6674a0301d58a0df2c707528501b6a2c911a0e082013fbff3ee7bc14ff83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Collagen - biosynthesis</topic><topic>Coloring Agents</topic><topic>Disease Models, Animal</topic><topic>Eosine Yellowish-(YS)</topic><topic>Fluorescent Dyes</topic><topic>Hematoxylin</topic><topic>Hypothyroidism - physiopathology</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Microscopy - methods</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Suture Techniques</topic><topic>Trachea - surgery</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimmermann, Elise</creatorcontrib><creatorcontrib>Ribas-Filho, Jurandir Marcondes</creatorcontrib><creatorcontrib>Malafaia, Osvaldo</creatorcontrib><creatorcontrib>Ribas, Carmen Austrália Paredes Marcondes</creatorcontrib><creatorcontrib>Nassif, Paulo Afonso Nunes</creatorcontrib><creatorcontrib>Stieven Filho, Edmar</creatorcontrib><creatorcontrib>Przysiezny, Paulo Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimmermann, Elise</au><au>Ribas-Filho, Jurandir Marcondes</au><au>Malafaia, Osvaldo</au><au>Ribas, Carmen Austrália Paredes Marcondes</au><au>Nassif, Paulo Afonso Nunes</au><au>Stieven Filho, Edmar</au><au>Przysiezny, Paulo Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tracheal suture in rats with hypothyroidism: wound healing study</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>24</volume><issue>4</issue><spage>282</spage><epage>289</epage><pages>282-289</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>To evaluate the influence of hypothyroidism in tracheal wound healing process.
A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done.
The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant.
Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity.</abstract><cop>Brazil</cop><pmid>19705026</pmid><doi>10.1590/S0102-86502009000400007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0102-8650 |
| ispartof | Acta cirurgica brasileira, 2009-07, Vol.24 (4), p.282-289 |
| issn | 0102-8650 1678-2674 0102-8650 |
| language | eng |
| recordid | cdi_crossref_primary_10_1590_S0102_86502009000400007 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Collagen - biosynthesis Coloring Agents Disease Models, Animal Eosine Yellowish-(YS) Fluorescent Dyes Hematoxylin Hypothyroidism - physiopathology Inflammation - pathology Male Microscopy - methods Rats Rats, Wistar Suture Techniques Trachea - surgery Wound Healing - physiology |
| title | Tracheal suture in rats with hypothyroidism: wound healing study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T09%3A57%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tracheal%20suture%20in%20rats%20with%20hypothyroidism:%20wound%20healing%20study&rft.jtitle=Acta%20cirurgica%20brasileira&rft.au=Zimmermann,%20Elise&rft.date=2009-07-01&rft.volume=24&rft.issue=4&rft.spage=282&rft.epage=289&rft.pages=282-289&rft.issn=0102-8650&rft.eissn=1678-2674&rft_id=info:doi/10.1590/S0102-86502009000400007&rft_dat=%3Cpubmed_cross%3E19705026%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19705026&rfr_iscdi=true |