Biodistribution of samarium-153-EDTMP in rats treated with docetaxel
Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats. Wistar male rats were randomly...
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| Veröffentlicht in: | Acta cirurgica brasileira 2009-01, Vol.24 (1), p.62-66 |
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| creator | Villarim Neto, Arthur Açucena, Maria Kadja Meneses Torres Pereira, Kércia Regina Santos Gomes Rêgo, Amália Cínthia Meneses Azevedo, Italo Medeiros Bernardo-Filho, Mário Medeiros, Aldo Cunha |
| description | Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats.
Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group received docetaxel (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) group rats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1 ml of samarium-153-EDTMP via orbital plexus (25 microCi). After 2 hours, the animals were killed and samples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determined in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland).
On the 9th day after the administration of the 2nd chemotherapy cycle, the rats had a significant weight loss (314.50+/-22.09g) compared (p |
| doi_str_mv | 10.1590/S0102-86502009000100013 |
| format | Article |
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Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group received docetaxel (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) group rats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1 ml of samarium-153-EDTMP via orbital plexus (25 microCi). After 2 hours, the animals were killed and samples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determined in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland).
On the 9th day after the administration of the 2nd chemotherapy cycle, the rats had a significant weight loss (314.50+/-22.09g) compared (p<0.5) to pre-treatment weight (353.66+/- 22.8). The % ATI/g in the samples of rats treated with samarium-153-EDTMP had a significant reduction in the right femur, left femur, kidney, liver and lungs of animals treated with docetaxel, compared to the control rats.
The combination of docetaxel and samarium-153-EDTMP was associated with a lower response rate in the biodistribution of the radiopharmaceutical to targeted tissues. Further investigation into the impact of docetaxel on biodistribution of samarium-153-EDTMP would complement the findings of this study.</description><identifier>ISSN: 0102-8650</identifier><identifier>EISSN: 1678-2674</identifier><identifier>EISSN: 0102-8650</identifier><identifier>DOI: 10.1590/S0102-86502009000100013</identifier><identifier>PMID: 19169545</identifier><language>eng</language><publisher>Brazil</publisher><subject>Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - pharmacokinetics ; Animals ; Antineoplastic Agents - pharmacology ; Bone Neoplasms - drug therapy ; Bone Neoplasms - metabolism ; Bone Neoplasms - secondary ; Drug Interactions ; Male ; Organometallic Compounds - administration & dosage ; Organometallic Compounds - pharmacokinetics ; Organophosphorus Compounds - administration & dosage ; Organophosphorus Compounds - pharmacokinetics ; Prostatic Neoplasms - drug therapy ; Random Allocation ; Rats ; Rats, Wistar ; Taxoids - pharmacology</subject><ispartof>Acta cirurgica brasileira, 2009-01, Vol.24 (1), p.62-66</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c314t-a8f202f77b9dd162ed80d725faa21ea6f22dac580ac321feff7429088714d5273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19169545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villarim Neto, Arthur</creatorcontrib><creatorcontrib>Açucena, Maria Kadja Meneses Torres</creatorcontrib><creatorcontrib>Pereira, Kércia Regina Santos Gomes</creatorcontrib><creatorcontrib>Rêgo, Amália Cínthia Meneses</creatorcontrib><creatorcontrib>Azevedo, Italo Medeiros</creatorcontrib><creatorcontrib>Bernardo-Filho, Mário</creatorcontrib><creatorcontrib>Medeiros, Aldo Cunha</creatorcontrib><title>Biodistribution of samarium-153-EDTMP in rats treated with docetaxel</title><title>Acta cirurgica brasileira</title><addtitle>Acta Cir Bras</addtitle><description>Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats.
Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group received docetaxel (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) group rats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1 ml of samarium-153-EDTMP via orbital plexus (25 microCi). After 2 hours, the animals were killed and samples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determined in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland).
On the 9th day after the administration of the 2nd chemotherapy cycle, the rats had a significant weight loss (314.50+/-22.09g) compared (p<0.5) to pre-treatment weight (353.66+/- 22.8). The % ATI/g in the samples of rats treated with samarium-153-EDTMP had a significant reduction in the right femur, left femur, kidney, liver and lungs of animals treated with docetaxel, compared to the control rats.
The combination of docetaxel and samarium-153-EDTMP was associated with a lower response rate in the biodistribution of the radiopharmaceutical to targeted tissues. Further investigation into the impact of docetaxel on biodistribution of samarium-153-EDTMP would complement the findings of this study.</description><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - pharmacokinetics</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>Drug Interactions</subject><subject>Male</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Organophosphorus Compounds - administration & dosage</subject><subject>Organophosphorus Compounds - pharmacokinetics</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Taxoids - pharmacology</subject><issn>0102-8650</issn><issn>1678-2674</issn><issn>0102-8650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkNtKAzEQhoMotlZfQfMC0Zlkc9hLbesBKgrW6yXdJBhpuyVJUd_eVYteeDH8DPzfMHyEnCGco6zh4gkQODNKAgeoAfq1H7FHhqi0YVzpap8Mf0sDcpTza9-oFIpDMsAaVS0rOSSTq9i5mEuKi22J3Zp2gWa7siluVwylYNPJ_P6RxjVNtmRakrfFO_oWywt1XeuLfffLY3IQ7DL7k12OyPP1dD6-ZbOHm7vx5Yy1AqvCrAkceNB6UTuHintnwGkug7UcvVWBc2dbacC2gmPwIeiK12CMxspJrsWI6J-7bepyTj40mxT7Xz8ahObLS_PtpfnnpSdPf8jNdrHy7o_biRCf-hddAA</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Villarim Neto, Arthur</creator><creator>Açucena, Maria Kadja Meneses Torres</creator><creator>Pereira, Kércia Regina Santos Gomes</creator><creator>Rêgo, Amália Cínthia Meneses</creator><creator>Azevedo, Italo Medeiros</creator><creator>Bernardo-Filho, Mário</creator><creator>Medeiros, Aldo Cunha</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090101</creationdate><title>Biodistribution of samarium-153-EDTMP in rats treated with docetaxel</title><author>Villarim Neto, Arthur ; Açucena, Maria Kadja Meneses Torres ; Pereira, Kércia Regina Santos Gomes ; Rêgo, Amália Cínthia Meneses ; Azevedo, Italo Medeiros ; Bernardo-Filho, Mário ; Medeiros, Aldo Cunha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-a8f202f77b9dd162ed80d725faa21ea6f22dac580ac321feff7429088714d5273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - pharmacokinetics</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - secondary</topic><topic>Drug Interactions</topic><topic>Male</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organometallic Compounds - pharmacokinetics</topic><topic>Organophosphorus Compounds - administration & dosage</topic><topic>Organophosphorus Compounds - pharmacokinetics</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Taxoids - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villarim Neto, Arthur</creatorcontrib><creatorcontrib>Açucena, Maria Kadja Meneses Torres</creatorcontrib><creatorcontrib>Pereira, Kércia Regina Santos Gomes</creatorcontrib><creatorcontrib>Rêgo, Amália Cínthia Meneses</creatorcontrib><creatorcontrib>Azevedo, Italo Medeiros</creatorcontrib><creatorcontrib>Bernardo-Filho, Mário</creatorcontrib><creatorcontrib>Medeiros, Aldo Cunha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta cirurgica brasileira</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villarim Neto, Arthur</au><au>Açucena, Maria Kadja Meneses Torres</au><au>Pereira, Kércia Regina Santos Gomes</au><au>Rêgo, Amália Cínthia Meneses</au><au>Azevedo, Italo Medeiros</au><au>Bernardo-Filho, Mário</au><au>Medeiros, Aldo Cunha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodistribution of samarium-153-EDTMP in rats treated with docetaxel</atitle><jtitle>Acta cirurgica brasileira</jtitle><addtitle>Acta Cir Bras</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>24</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>0102-8650</issn><eissn>1678-2674</eissn><eissn>0102-8650</eissn><abstract>Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats.
Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group received docetaxel (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) group rats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1 ml of samarium-153-EDTMP via orbital plexus (25 microCi). After 2 hours, the animals were killed and samples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determined in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland).
On the 9th day after the administration of the 2nd chemotherapy cycle, the rats had a significant weight loss (314.50+/-22.09g) compared (p<0.5) to pre-treatment weight (353.66+/- 22.8). The % ATI/g in the samples of rats treated with samarium-153-EDTMP had a significant reduction in the right femur, left femur, kidney, liver and lungs of animals treated with docetaxel, compared to the control rats.
The combination of docetaxel and samarium-153-EDTMP was associated with a lower response rate in the biodistribution of the radiopharmaceutical to targeted tissues. Further investigation into the impact of docetaxel on biodistribution of samarium-153-EDTMP would complement the findings of this study.</abstract><cop>Brazil</cop><pmid>19169545</pmid><doi>10.1590/S0102-86502009000100013</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - pharmacokinetics Animals Antineoplastic Agents - pharmacology Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - secondary Drug Interactions Male Organometallic Compounds - administration & dosage Organometallic Compounds - pharmacokinetics Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - pharmacokinetics Prostatic Neoplasms - drug therapy Random Allocation Rats Rats, Wistar Taxoids - pharmacology |
| title | Biodistribution of samarium-153-EDTMP in rats treated with docetaxel |
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