Desreplicação de alcaloides aporfínicos e oxoaporfínicos de Unonopsis guatterioides por ESI-IT-MS

Desreplicação de alcaloides aporfínicos e oxoaporfínicos de Unonopsis guatterioides por ESI-IT-MS

The dereplication of aporphine and oxoaporphine alkaloids by direct infusion in ESI-IT-MSn system was applied for alkaloidal fractions of the Unonopsis guatterioides (Annonaceae). Its main advantage over other dereplication methods is the ability to quickly identify substances in complex mixtures wi...

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Veröffentlicht in:Química Nova 2012, Vol.35 (5), p.944-947
Hauptverfasser: Silva, Felipe Moura Araújo da, Koolen, Hector Henrique Ferreira, Almeida, Richardson Alves de, Souza, Afonso Duarte Leão de, Pinheiro, Maria Lúcia Belém, Costa, Emmanoel Vilaça
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alkaloid dereplication
Annonaceae
Unonopsis guatterioides
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container_end_page 947
container_issue 5
container_start_page 944
container_title Química Nova
container_volume 35
creator Silva, Felipe Moura Araújo da
Koolen, Hector Henrique Ferreira
Almeida, Richardson Alves de
Souza, Afonso Duarte Leão de
Pinheiro, Maria Lúcia Belém
Costa, Emmanoel Vilaça
description The dereplication of aporphine and oxoaporphine alkaloids by direct infusion in ESI-IT-MSn system was applied for alkaloidal fractions of the Unonopsis guatterioides (Annonaceae). Its main advantage over other dereplication methods is the ability to quickly identify substances in complex mixtures without the use of coupled techniques and expensive databases. By only the fragmentation keys and comparison with literature data the aporphine alkaloids anonaine, asimilobine and nornuciferine were identified. The nornuciferine is being reported for the first time in Unonopsis. The oxoaporphine alkaloids liriodenine and lisycamine were identified in the alkaloidal fractions by comparison with the fragmentations of authentic samples.
doi_str_mv 10.1590/S0100-40422012000500015
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subjects alkaloid dereplication
Annonaceae
Unonopsis guatterioides
title Desreplicação de alcaloides aporfínicos e oxoaporfínicos de Unonopsis guatterioides por ESI-IT-MS
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