Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B
ABSTRACT Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational...
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| creator | MONTEIRO, Larissa Cavalcanti RIBEIRO, Isabella Lima Arrais BATISTA, Roberta Ferreti Bonan Dantas MACIEL, Panmella Pereira VALENÇA, Ana Maria Gondim DULGHEROFF, Ana Carolina Bernardes SOUZA, Joelma Rodrigues CAVALCANTI, Yuri Wanderley CASTELLANO, Lucio Roberto Cançado BONAN, Paulo Rogério Ferreti |
| description | ABSTRACT Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected from40 individuals diagnosed with ALL and from40 healthy subjects, as a comparative group, matched by age and gender with ALL group. The mean age for both groups were 8 years-old. The isolation and identification of the Candidaspecies were performed using the CHROMagarCandidaTM and confirmed by polymerase chain reaction. The samples were subjected to antifungal susceptibility by microdilution assay for nystatin and amphotericin B. Salivary alterations and chemotherapy-induced oralmucositis were evaluated using modifiedOral Assessment Guide. Results: The positivity to Candida was higher inALL individuals (32.5%,13/40)than in a comparative group(2.5%, 1/40) (p |
| doi_str_mv | 10.1590/1981-86372019000183558 |
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RESUMO Objetivo: o objetivo deste estudo foi avaliar a prevalência e colonização de Candida na cavidade oral de indivíduos pediátricos com leucemia linfocítica aguda (LLA) e sua susceptibilidade/resistência à nistatina e à anfotericina B. Métodos: estudo transversal observacional com abordagem descritiva e analítica. A saliva foi coletada de 40 indivíduos diagnosticados com LLA e de 40 indivíduos saudáveis, como grupo comparativo, combinados por idade e sexo com o grupo LLA. A idade média para ambos os grupos foi de 8 anos de idade. O isolamento e a identificação das espécies de Candida foram realizados utilizando o CHROMagarCandidaTM e confirmados pela reação em cadeia da polimerase. As amostras foram submetidas a susceptibilidade antifúngica por meio de ensaio de microdiluição para nistatina e anfotericina B. As alterações salivares e a mucosite oral induzida por quimioterapia foram avaliadas utilizando o Guia de avaliação modificada. Resultados: A positividade para Candida foi superior aos indivíduos in situ (32,5%, 13/40) do que em um grupo comparativo (2,5%, 1/40) (p <0,001). Candida albicans foi a cepa mais prevalente (86,6%). A mucosite foi diretamente associada à colonização positive por Candida (p = 0,017) no grupo LLA, mas não relacionada com alterações salivares (p = 0,479). Seis estirpes de C. albicans (54,5%), no grupo LLA, eram resistentes à nistatina e todas as cepas não eram suscetíveis à anfotericina B. Conclusão: A colonização por Candida foi associada à condição LLA e à mucosite oral nesses indivíduos. C. albicans era a cepa predominante e a maioria das amostras eram resistentes aos agentes antifúngicos testados, nistatina e anfotericina B.</description><identifier>ISSN: 0103-6971</identifier><identifier>ISSN: 1981-8637</identifier><identifier>EISSN: 1981-8637</identifier><identifier>DOI: 10.1590/1981-86372019000183558</identifier><language>eng</language><publisher>Faculdade São Leopoldo Mandic</publisher><subject>candida ; DENTISTRY, ORAL SURGERY & MEDICINE ; precursor cell lymphoblastic leukemia-lymphoma ; prevalence</subject><ispartof>RGO - Revista Gaúcha de Odontologia, 2019, Vol.67, p.e20190018</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2008-7bd7726cc35033117634085e9b049c99b48596852345e525fdd9fddbcb4601773</cites><orcidid>0000-0003-2126-8623 ; 0000-0002-3570-9904 ; 0000-0002-4449-4343 ; 0000-0002-1456-9009 ; 0000-0001-8737-6032 ; 0000-0001-6538-6811 ; 0000-0001-8460-3981 ; 0000-0002-7349-0878 ; 0000-0003-0851-5298 ; 0000-0003-0168-5833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,864,885,27924,27925</link.rule.ids></links><search><creatorcontrib>MONTEIRO, Larissa Cavalcanti</creatorcontrib><creatorcontrib>RIBEIRO, Isabella Lima Arrais</creatorcontrib><creatorcontrib>BATISTA, Roberta Ferreti Bonan Dantas</creatorcontrib><creatorcontrib>MACIEL, Panmella Pereira</creatorcontrib><creatorcontrib>VALENÇA, Ana Maria Gondim</creatorcontrib><creatorcontrib>DULGHEROFF, Ana Carolina Bernardes</creatorcontrib><creatorcontrib>SOUZA, Joelma Rodrigues</creatorcontrib><creatorcontrib>CAVALCANTI, Yuri Wanderley</creatorcontrib><creatorcontrib>CASTELLANO, Lucio Roberto Cançado</creatorcontrib><creatorcontrib>BONAN, Paulo Rogério Ferreti</creatorcontrib><title>Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B</title><title>RGO - Revista Gaúcha de Odontologia</title><addtitle>RGO, Rev. Gaúch. Odontol</addtitle><description>ABSTRACT Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected from40 individuals diagnosed with ALL and from40 healthy subjects, as a comparative group, matched by age and gender with ALL group. The mean age for both groups were 8 years-old. The isolation and identification of the Candidaspecies were performed using the CHROMagarCandidaTM and confirmed by polymerase chain reaction. The samples were subjected to antifungal susceptibility by microdilution assay for nystatin and amphotericin B. Salivary alterations and chemotherapy-induced oralmucositis were evaluated using modifiedOral Assessment Guide. Results: The positivity to Candida was higher inALL individuals (32.5%,13/40)than in a comparative group(2.5%, 1/40) (p<0.001). Candida albicans was the most prevalent strain (86.6%). The mucositis was directly associated with positive Candidacolonization (p=0.017) in the ALL group but not related with salivary alterations (p= 0.479). Six strains of C. albicans (54.5%), on ALL group, were resistant to nystatin and all strains were not susceptible to amphotericin B. Conclusion: Candida colonization was associated with ALL condition and with oral mucositis in these individuals. C. albicans was the prevalent strain and most samples were resistant to antifungal agents tested, nystatin and amphotericin B.
RESUMO Objetivo: o objetivo deste estudo foi avaliar a prevalência e colonização de Candida na cavidade oral de indivíduos pediátricos com leucemia linfocítica aguda (LLA) e sua susceptibilidade/resistência à nistatina e à anfotericina B. Métodos: estudo transversal observacional com abordagem descritiva e analítica. A saliva foi coletada de 40 indivíduos diagnosticados com LLA e de 40 indivíduos saudáveis, como grupo comparativo, combinados por idade e sexo com o grupo LLA. A idade média para ambos os grupos foi de 8 anos de idade. O isolamento e a identificação das espécies de Candida foram realizados utilizando o CHROMagarCandidaTM e confirmados pela reação em cadeia da polimerase. As amostras foram submetidas a susceptibilidade antifúngica por meio de ensaio de microdiluição para nistatina e anfotericina B. As alterações salivares e a mucosite oral induzida por quimioterapia foram avaliadas utilizando o Guia de avaliação modificada. Resultados: A positividade para Candida foi superior aos indivíduos in situ (32,5%, 13/40) do que em um grupo comparativo (2,5%, 1/40) (p <0,001). Candida albicans foi a cepa mais prevalente (86,6%). A mucosite foi diretamente associada à colonização positive por Candida (p = 0,017) no grupo LLA, mas não relacionada com alterações salivares (p = 0,479). Seis estirpes de C. albicans (54,5%), no grupo LLA, eram resistentes à nistatina e todas as cepas não eram suscetíveis à anfotericina B. Conclusão: A colonização por Candida foi associada à condição LLA e à mucosite oral nesses indivíduos. C. albicans era a cepa predominante e a maioria das amostras eram resistentes aos agentes antifúngicos testados, nistatina e anfotericina B.</description><subject>candida</subject><subject>DENTISTRY, ORAL SURGERY & MEDICINE</subject><subject>precursor cell lymphoblastic leukemia-lymphoma</subject><subject>prevalence</subject><issn>0103-6971</issn><issn>1981-8637</issn><issn>1981-8637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNplkd1KAzEQhYMoWKqvIHmB1clm83epxZ9CwQv1OmSTrEbWTUlSpW9v2ooIXgwDM_MdDmcQuiBwSZiCK6IkaSSnogWiAIBIypg8QrPfxTGaAQHacCXIKTrPOfQAnWjbTtEZmhZmcsEZHCcckxmxNZ-hbHEc8Nq7YEoKFod68hncxowZf4Xyhq9XK1w5HErGeZOtX5fQh3EHloinbS6mhGl_Yj7Wb7H4KlMHN2foZKgq_vynz9HL3e3z4qFZPd4vF9erxrYAshG9E6Ll1lIGlBIiOO1AMq966JRVqu8kU1yylnbMs5YNzqlave07DkQIOkfLg66L5l2vU_gwaaujCXo_iOlVm1SCHb02Q-ehV0MrbY2EqV2DwXHCjaBDTXCOLg9a2QY_Rv0eN2mq5vXTLmP9N3wACqoC_ADYFHNOfvg1QEDvvqb_gfuv0W9nHYcO</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>MONTEIRO, Larissa Cavalcanti</creator><creator>RIBEIRO, Isabella Lima Arrais</creator><creator>BATISTA, Roberta Ferreti Bonan Dantas</creator><creator>MACIEL, Panmella Pereira</creator><creator>VALENÇA, Ana Maria Gondim</creator><creator>DULGHEROFF, Ana Carolina Bernardes</creator><creator>SOUZA, Joelma Rodrigues</creator><creator>CAVALCANTI, Yuri Wanderley</creator><creator>CASTELLANO, Lucio Roberto Cançado</creator><creator>BONAN, Paulo Rogério Ferreti</creator><general>Faculdade São Leopoldo Mandic</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2126-8623</orcidid><orcidid>https://orcid.org/0000-0002-3570-9904</orcidid><orcidid>https://orcid.org/0000-0002-4449-4343</orcidid><orcidid>https://orcid.org/0000-0002-1456-9009</orcidid><orcidid>https://orcid.org/0000-0001-8737-6032</orcidid><orcidid>https://orcid.org/0000-0001-6538-6811</orcidid><orcidid>https://orcid.org/0000-0001-8460-3981</orcidid><orcidid>https://orcid.org/0000-0002-7349-0878</orcidid><orcidid>https://orcid.org/0000-0003-0851-5298</orcidid><orcidid>https://orcid.org/0000-0003-0168-5833</orcidid></search><sort><creationdate>201901</creationdate><title>Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B</title><author>MONTEIRO, Larissa Cavalcanti ; RIBEIRO, Isabella Lima Arrais ; BATISTA, Roberta Ferreti Bonan Dantas ; MACIEL, Panmella Pereira ; VALENÇA, Ana Maria Gondim ; DULGHEROFF, Ana Carolina Bernardes ; SOUZA, Joelma Rodrigues ; CAVALCANTI, Yuri Wanderley ; CASTELLANO, Lucio Roberto Cançado ; BONAN, Paulo Rogério Ferreti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2008-7bd7726cc35033117634085e9b049c99b48596852345e525fdd9fddbcb4601773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>candida</topic><topic>DENTISTRY, ORAL SURGERY & MEDICINE</topic><topic>precursor cell lymphoblastic leukemia-lymphoma</topic><topic>prevalence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONTEIRO, Larissa Cavalcanti</creatorcontrib><creatorcontrib>RIBEIRO, Isabella Lima Arrais</creatorcontrib><creatorcontrib>BATISTA, Roberta Ferreti Bonan Dantas</creatorcontrib><creatorcontrib>MACIEL, Panmella Pereira</creatorcontrib><creatorcontrib>VALENÇA, Ana Maria Gondim</creatorcontrib><creatorcontrib>DULGHEROFF, Ana Carolina Bernardes</creatorcontrib><creatorcontrib>SOUZA, Joelma Rodrigues</creatorcontrib><creatorcontrib>CAVALCANTI, Yuri Wanderley</creatorcontrib><creatorcontrib>CASTELLANO, Lucio Roberto Cançado</creatorcontrib><creatorcontrib>BONAN, Paulo Rogério Ferreti</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>RGO - Revista Gaúcha de Odontologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MONTEIRO, Larissa Cavalcanti</au><au>RIBEIRO, Isabella Lima Arrais</au><au>BATISTA, Roberta Ferreti Bonan Dantas</au><au>MACIEL, Panmella Pereira</au><au>VALENÇA, Ana Maria Gondim</au><au>DULGHEROFF, Ana Carolina Bernardes</au><au>SOUZA, Joelma Rodrigues</au><au>CAVALCANTI, Yuri Wanderley</au><au>CASTELLANO, Lucio Roberto Cançado</au><au>BONAN, Paulo Rogério Ferreti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B</atitle><jtitle>RGO - Revista Gaúcha de Odontologia</jtitle><addtitle>RGO, Rev. Gaúch. Odontol</addtitle><date>2019-01</date><risdate>2019</risdate><volume>67</volume><spage>e20190018</spage><pages>e20190018-</pages><issn>0103-6971</issn><issn>1981-8637</issn><eissn>1981-8637</eissn><abstract>ABSTRACT Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected from40 individuals diagnosed with ALL and from40 healthy subjects, as a comparative group, matched by age and gender with ALL group. The mean age for both groups were 8 years-old. The isolation and identification of the Candidaspecies were performed using the CHROMagarCandidaTM and confirmed by polymerase chain reaction. The samples were subjected to antifungal susceptibility by microdilution assay for nystatin and amphotericin B. Salivary alterations and chemotherapy-induced oralmucositis were evaluated using modifiedOral Assessment Guide. Results: The positivity to Candida was higher inALL individuals (32.5%,13/40)than in a comparative group(2.5%, 1/40) (p<0.001). Candida albicans was the most prevalent strain (86.6%). The mucositis was directly associated with positive Candidacolonization (p=0.017) in the ALL group but not related with salivary alterations (p= 0.479). Six strains of C. albicans (54.5%), on ALL group, were resistant to nystatin and all strains were not susceptible to amphotericin B. Conclusion: Candida colonization was associated with ALL condition and with oral mucositis in these individuals. C. albicans was the prevalent strain and most samples were resistant to antifungal agents tested, nystatin and amphotericin B.
RESUMO Objetivo: o objetivo deste estudo foi avaliar a prevalência e colonização de Candida na cavidade oral de indivíduos pediátricos com leucemia linfocítica aguda (LLA) e sua susceptibilidade/resistência à nistatina e à anfotericina B. Métodos: estudo transversal observacional com abordagem descritiva e analítica. A saliva foi coletada de 40 indivíduos diagnosticados com LLA e de 40 indivíduos saudáveis, como grupo comparativo, combinados por idade e sexo com o grupo LLA. A idade média para ambos os grupos foi de 8 anos de idade. O isolamento e a identificação das espécies de Candida foram realizados utilizando o CHROMagarCandidaTM e confirmados pela reação em cadeia da polimerase. As amostras foram submetidas a susceptibilidade antifúngica por meio de ensaio de microdiluição para nistatina e anfotericina B. As alterações salivares e a mucosite oral induzida por quimioterapia foram avaliadas utilizando o Guia de avaliação modificada. Resultados: A positividade para Candida foi superior aos indivíduos in situ (32,5%, 13/40) do que em um grupo comparativo (2,5%, 1/40) (p <0,001). Candida albicans foi a cepa mais prevalente (86,6%). A mucosite foi diretamente associada à colonização positive por Candida (p = 0,017) no grupo LLA, mas não relacionada com alterações salivares (p = 0,479). Seis estirpes de C. albicans (54,5%), no grupo LLA, eram resistentes à nistatina e todas as cepas não eram suscetíveis à anfotericina B. Conclusão: A colonização por Candida foi associada à condição LLA e à mucosite oral nesses indivíduos. C. albicans era a cepa predominante e a maioria das amostras eram resistentes aos agentes antifúngicos testados, nistatina e anfotericina B.</abstract><pub>Faculdade São Leopoldo Mandic</pub><doi>10.1590/1981-86372019000183558</doi><orcidid>https://orcid.org/0000-0003-2126-8623</orcidid><orcidid>https://orcid.org/0000-0002-3570-9904</orcidid><orcidid>https://orcid.org/0000-0002-4449-4343</orcidid><orcidid>https://orcid.org/0000-0002-1456-9009</orcidid><orcidid>https://orcid.org/0000-0001-8737-6032</orcidid><orcidid>https://orcid.org/0000-0001-6538-6811</orcidid><orcidid>https://orcid.org/0000-0001-8460-3981</orcidid><orcidid>https://orcid.org/0000-0002-7349-0878</orcidid><orcidid>https://orcid.org/0000-0003-0851-5298</orcidid><orcidid>https://orcid.org/0000-0003-0168-5833</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | candida DENTISTRY, ORAL SURGERY & MEDICINE precursor cell lymphoblastic leukemia-lymphoma prevalence |
| title | Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B |
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