Can blood urea Nitrogen-to-Albumin ratio predict mortality in patients with moderate-to-severe COVID-19 pneumonia hospitalized in the intensive care unit?
Many laboratory parameters allow to follow up the course of the disease and reveal its clinical severity, particularly in patients with coronavirus disease 2019 (COVID-19) pneumonia. In this study, we aimed to investigate the role of the blood urea nitrogen-to-albumin ratio in predicting the mortali...
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| Veröffentlicht in: | Revista da Associacao Medica Brasileira (1992) 2021-10, Vol.67 (10), p.1421-1426 |
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| container_title | Revista da Associacao Medica Brasileira (1992) |
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| creator | Ata, Filiz As, Ahmet Kagan Engin, Mesut Kat, Nurcan Kacmaz Ata, Yusuf Turk, Tamer |
| description | Many laboratory parameters allow to follow up the course of the disease and reveal its clinical severity, particularly in patients with coronavirus disease 2019 (COVID-19) pneumonia. In this study, we aimed to investigate the role of the blood urea nitrogen-to-albumin ratio in predicting the mortality in COVID-19 patients with moderate-to-severe disease who are hospitalized in the intensive care unit.
A total of 358 patients who were hospitalized in intensive care unit at our hospital between November 1, 2020 and May 15, 2021 were included in this study. During their course of intensive care, surviving patients were included in Group 1 and nonsurviving patients in Group 2.
There were no statistically significant differences between the two groups in terms of gender, smoking, and chronic obstructive pulmonary disease rates. In multivariate logistic regression analysis, advanced age (OR 1.038, 95%CI 1.014-1.064, p=0.002), neutrophil-to-lymphocyte ratio (OR 1.226, 95%CI 1.020-1.475, p=0.030), blood urea nitrogen-to-albumin ratio (OR 2.693, 95%CI 2.019-3.593, p |
| doi_str_mv | 10.1590/1806-9282.20210610 |
| format | Magazinearticle |
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A total of 358 patients who were hospitalized in intensive care unit at our hospital between November 1, 2020 and May 15, 2021 were included in this study. During their course of intensive care, surviving patients were included in Group 1 and nonsurviving patients in Group 2.
There were no statistically significant differences between the two groups in terms of gender, smoking, and chronic obstructive pulmonary disease rates. In multivariate logistic regression analysis, advanced age (OR 1.038, 95%CI 1.014-1.064, p=0.002), neutrophil-to-lymphocyte ratio (OR 1.226, 95%CI 1.020-1.475, p=0.030), blood urea nitrogen-to-albumin ratio (OR 2.693, 95%CI 2.019-3.593, p<0.001), and chest computed tomography severity score (OR 1.163, 95%CI 1.105-1.225, p<0.001) values were determined as independent predictors for in-hospital mortality.
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A total of 358 patients who were hospitalized in intensive care unit at our hospital between November 1, 2020 and May 15, 2021 were included in this study. During their course of intensive care, surviving patients were included in Group 1 and nonsurviving patients in Group 2.
There were no statistically significant differences between the two groups in terms of gender, smoking, and chronic obstructive pulmonary disease rates. In multivariate logistic regression analysis, advanced age (OR 1.038, 95%CI 1.014-1.064, p=0.002), neutrophil-to-lymphocyte ratio (OR 1.226, 95%CI 1.020-1.475, p=0.030), blood urea nitrogen-to-albumin ratio (OR 2.693, 95%CI 2.019-3.593, p<0.001), and chest computed tomography severity score (OR 1.163, 95%CI 1.105-1.225, p<0.001) values were determined as independent predictors for in-hospital mortality.
In this study, we showed that the blood urea nitrogen-to-albumin ratio, which was previously shown as a predictor of mortality in patients with various pneumonia, was an independent predictor of mortality in patients with COVID-19 pneumonia.</description><subject>Albumins</subject><subject>Blood Urea Nitrogen</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - mortality</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Retrospective Studies</subject><issn>0104-4230</issn><issn>1806-9282</issn><fulltext>true</fulltext><rsrctype>magazinearticle</rsrctype><creationdate>2021</creationdate><recordtype>magazinearticle</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1OwzAQRi0Egqr0AiyQL5AytmMnXiFUfiVEN8A2cpIJtdTEke0UlaNwWhIBXY0037xPmkfIBYMlkxquWA4q0TznSw6cgWJwRGaH5TGZAYM0SbmAM7IIwZbAIZOSs_yUnAkJLNdKz8j3ynS03DpX08GjoS82eveBXRJdcrMth9Z21JtoHe091raKtHU-mq2NezpG_RhhFwP9tHEzRjWOxzjBAXfoka7W70-3CdO073BoXWcN3bjQ26niC-upI25wHBG7YHdIKzNSQ2fj9Tk5acw24OJvzsnb_d3r6jF5Xj88rW6ek0rkKiZccsE01Hx82_BGp0rXaZZpofKM5ygBMJNaYlM1iglsTM4kKJmKtAQldCnmhP_2Vt6F4LEpem9b4_cFg2JyXUxai0lr8e96hC5_oX4oW6wPyL9Z8QPqBnqT</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Ata, Filiz</creator><creator>As, Ahmet Kagan</creator><creator>Engin, Mesut</creator><creator>Kat, Nurcan Kacmaz</creator><creator>Ata, Yusuf</creator><creator>Turk, Tamer</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8205-1850</orcidid><orcidid>https://orcid.org/0000-0003-2472-1681</orcidid><orcidid>https://orcid.org/0000-0003-1668-020X</orcidid><orcidid>https://orcid.org/0000-0001-8098-4393</orcidid><orcidid>https://orcid.org/0000-0002-1105-5862</orcidid><orcidid>https://orcid.org/0000-0003-2418-5823</orcidid></search><sort><creationdate>20211001</creationdate><title>Can blood urea Nitrogen-to-Albumin ratio predict mortality in patients with moderate-to-severe COVID-19 pneumonia hospitalized in the intensive care unit?</title><author>Ata, Filiz ; As, Ahmet Kagan ; Engin, Mesut ; Kat, Nurcan Kacmaz ; Ata, Yusuf ; Turk, Tamer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2523190d2282a2f9469d4779368728e500e7595efcf613efa815065434b0639b3</frbrgroupid><rsrctype>magazinearticle</rsrctype><prefilter>magazinearticle</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Albumins</topic><topic>Blood Urea Nitrogen</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - mortality</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ata, Filiz</creatorcontrib><creatorcontrib>As, Ahmet Kagan</creatorcontrib><creatorcontrib>Engin, Mesut</creatorcontrib><creatorcontrib>Kat, Nurcan Kacmaz</creatorcontrib><creatorcontrib>Ata, Yusuf</creatorcontrib><creatorcontrib>Turk, Tamer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Revista da Associacao Medica Brasileira (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ata, Filiz</au><au>As, Ahmet Kagan</au><au>Engin, Mesut</au><au>Kat, Nurcan Kacmaz</au><au>Ata, Yusuf</au><au>Turk, Tamer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can blood urea Nitrogen-to-Albumin ratio predict mortality in patients with moderate-to-severe COVID-19 pneumonia hospitalized in the intensive care unit?</atitle><jtitle>Revista da Associacao Medica Brasileira (1992)</jtitle><addtitle>Rev Assoc Med Bras (1992)</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>67</volume><issue>10</issue><spage>1421</spage><epage>1426</epage><pages>1421-1426</pages><issn>0104-4230</issn><eissn>1806-9282</eissn><abstract>Many laboratory parameters allow to follow up the course of the disease and reveal its clinical severity, particularly in patients with coronavirus disease 2019 (COVID-19) pneumonia. In this study, we aimed to investigate the role of the blood urea nitrogen-to-albumin ratio in predicting the mortality in COVID-19 patients with moderate-to-severe disease who are hospitalized in the intensive care unit.
A total of 358 patients who were hospitalized in intensive care unit at our hospital between November 1, 2020 and May 15, 2021 were included in this study. During their course of intensive care, surviving patients were included in Group 1 and nonsurviving patients in Group 2.
There were no statistically significant differences between the two groups in terms of gender, smoking, and chronic obstructive pulmonary disease rates. In multivariate logistic regression analysis, advanced age (OR 1.038, 95%CI 1.014-1.064, p=0.002), neutrophil-to-lymphocyte ratio (OR 1.226, 95%CI 1.020-1.475, p=0.030), blood urea nitrogen-to-albumin ratio (OR 2.693, 95%CI 2.019-3.593, p<0.001), and chest computed tomography severity score (OR 1.163, 95%CI 1.105-1.225, p<0.001) values were determined as independent predictors for in-hospital mortality.
In this study, we showed that the blood urea nitrogen-to-albumin ratio, which was previously shown as a predictor of mortality in patients with various pneumonia, was an independent predictor of mortality in patients with COVID-19 pneumonia.</abstract><cop>Brazil</cop><pmid>35018969</pmid><doi>10.1590/1806-9282.20210610</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8205-1850</orcidid><orcidid>https://orcid.org/0000-0003-2472-1681</orcidid><orcidid>https://orcid.org/0000-0003-1668-020X</orcidid><orcidid>https://orcid.org/0000-0001-8098-4393</orcidid><orcidid>https://orcid.org/0000-0002-1105-5862</orcidid><orcidid>https://orcid.org/0000-0003-2418-5823</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Albumins Blood Urea Nitrogen COVID-19 - diagnosis COVID-19 - mortality Hospital Mortality Humans Intensive Care Units Retrospective Studies |
| title | Can blood urea Nitrogen-to-Albumin ratio predict mortality in patients with moderate-to-severe COVID-19 pneumonia hospitalized in the intensive care unit? |
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