Alginate/Chitosan Associates a Platelet-rich in Fibrin Exudates as Drug Delivery Systems in Wounds: a Mini-Review

Abstract The use of biopolymers and platelet-rich fibrin (PRF) is currently investigated as an excellent application biomaterial in the tissue engineering field. Natural biomaterials with application potential in tissue engineering and regenerative medicine are due to their characteristics in biocom...

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Veröffentlicht in:Brazilian Archives of Biology and Technology 2023-01, Vol.66
Hauptverfasser: Barbosa, Carlos de Almeida, Simeoni, Rossana Baggio, Gamba, Luize Kremer, Ribeiro, Victoria Stadler Tasca, Cardoso, Marco André, Cunha, Ricardo Correa, Souza, Clayton Fernandes de, Francisco, Júlio Cesar, Guarita-Souza, Luiz Cesar, Fernandes, Beatriz Luci
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container_title Brazilian Archives of Biology and Technology
container_volume 66
creator Barbosa, Carlos de Almeida
Simeoni, Rossana Baggio
Gamba, Luize Kremer
Ribeiro, Victoria Stadler Tasca
Cardoso, Marco André
Cunha, Ricardo Correa
Souza, Clayton Fernandes de
Francisco, Júlio Cesar
Guarita-Souza, Luiz Cesar
Fernandes, Beatriz Luci
description Abstract The use of biopolymers and platelet-rich fibrin (PRF) is currently investigated as an excellent application biomaterial in the tissue engineering field. Natural biomaterials with application potential in tissue engineering and regenerative medicine are due to their characteristics in biocompatibility, biodegradability, and mechanical characteristic. Though, the basic knowledge of three‐dimensional fibrin scaffold and chitosan/alginate processing technology combined with an understanding of the physical-chemical properties of this natural biomaterial is necessary for proper application in regenerative medicine and tissue engineering. This mini review summarizes the information on the composition of chitosan/alginate and PRF in medical area and discusses recent developments with a special focus on its use for the application of drug delivery. The most important advances and stimulating applications are studies in regenerative medicine and tissue engineering, for wound healing to treat burns, tumor treatment, nanoparticle carriers, and drug delivery systems.
doi_str_mv 10.1590/1678-4324-2023220880
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subjects Drug delivery systems, chitosan/alginate, platelet-rich fibrin
Regeneration
Wound healing
title Alginate/Chitosan Associates a Platelet-rich in Fibrin Exudates as Drug Delivery Systems in Wounds: a Mini-Review
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