Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis
To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase. We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%) + hyalu...
Gespeichert in:
| Veröffentlicht in: | International Brazilian Journal of Urology 2012-12, Vol.38 (6), p.802-808 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 808 |
|---|---|
| container_issue | 6 |
| container_start_page | 802 |
| container_title | International Brazilian Journal of Urology |
| container_volume | 38 |
| creator | Favorito, Luciano Alves Balassiano, Carlos M Rosado, João Pedro Cardoso, Luiz Eduardo M Costa, Waldemar Silva Sampaio, Francisco José Barcellos |
| description | To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase.
We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%) + hyaluronidase. The parents of seven of these patients opted for circumcision (control group). The other fifty-three patients were submitted to clinical treatment. The samples were stained with Weigert's resorcin-fuchsin (analysis of the elastic fibers) and Picro-Sirius Red, for analysis of the collagen. The volumetric density of the elastic fibers was determined by stereological methods.
Only eight (15 %) of the fifty-three patients submitted to topical treatment presented failure, being indicated for circumcision (histological analysis). We observed an increase of the collagen type III of the patients submitted to topical treatment. The quantification showed a reduction of the volumetric density of the prepuce's elastic fibers of the patients submitted to the cream treatment, when compared to the control group (p = 0.056). The volumetric density of the elastic fibers of the prepuce at the group not submitted to topical treatment showed an average of 14.60% (11.06 to 21.64%); in the group submitted to the cream treatment, the volumetric density of the elastic fibers of the prepuce showed an average of 10.34% (3.45 to 17.9%).
The topical treatment of phimosis with betamethasone 0.2 % + hyaluronidase had a success rate of 85 %. Patients with failure of the topical treatment with steroid had histological alterations in the prepuce. |
| doi_str_mv | 10.1590/1677-553820133806802 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_doaj_</sourceid><recordid>TN_cdi_crossref_primary_10_1590_1677_553820133806802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_d5efe4c5ee104aacb18bfe720a260036</doaj_id><sourcerecordid>23302400</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-c41c302e5c0e68a68668a255db4fb4bb28c45626aa1bff9e00bff68a7970dd233</originalsourceid><addsrcrecordid>eNpdUctOwzAQtBCI8voDhPwDhbUTO8kRVTwqVeIAnKONs6ZGSRM5Doi_x01LD1x2vTs7Y6-HsWsBt0IVcCd0ls2VSnIJIkly0DnII3Y2tbUQxfH-vB2ZsfNh-ASQBWTilM1kkoBMAc7Y12vwowmjx4bjBpufwQ28szysifdr13bBGd576kdD3G14j8HRJgz824U1t-gaqnnoemeiQPCEoY0wN13bo4_QNDZuJiSWk2S84pKdWGwGutrnC_b--PC2eJ6vXp6Wi_vV3KRShRiFiS8lZYB0jjrXMUql6iq1VVpVMjep0lIjisraggBiiiNZkUFdxy0v2HKnW3f4Wfbeteh_yg5dOTU6_1Gijys2VNaKLKVGEQlIEU0l8spSJgGlBkh01Ep3WsZ3w-DJHvQElFtLyu1_l_8sibSbHa0fq5bqA-nPg-QXZE-J8w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Favorito, Luciano Alves ; Balassiano, Carlos M ; Rosado, João Pedro ; Cardoso, Luiz Eduardo M ; Costa, Waldemar Silva ; Sampaio, Francisco José Barcellos</creator><creatorcontrib>Favorito, Luciano Alves ; Balassiano, Carlos M ; Rosado, João Pedro ; Cardoso, Luiz Eduardo M ; Costa, Waldemar Silva ; Sampaio, Francisco José Barcellos</creatorcontrib><description>To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase.
We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%) + hyaluronidase. The parents of seven of these patients opted for circumcision (control group). The other fifty-three patients were submitted to clinical treatment. The samples were stained with Weigert's resorcin-fuchsin (analysis of the elastic fibers) and Picro-Sirius Red, for analysis of the collagen. The volumetric density of the elastic fibers was determined by stereological methods.
Only eight (15 %) of the fifty-three patients submitted to topical treatment presented failure, being indicated for circumcision (histological analysis). We observed an increase of the collagen type III of the patients submitted to topical treatment. The quantification showed a reduction of the volumetric density of the prepuce's elastic fibers of the patients submitted to the cream treatment, when compared to the control group (p = 0.056). The volumetric density of the elastic fibers of the prepuce at the group not submitted to topical treatment showed an average of 14.60% (11.06 to 21.64%); in the group submitted to the cream treatment, the volumetric density of the elastic fibers of the prepuce showed an average of 10.34% (3.45 to 17.9%).
The topical treatment of phimosis with betamethasone 0.2 % + hyaluronidase had a success rate of 85 %. Patients with failure of the topical treatment with steroid had histological alterations in the prepuce.</description><identifier>ISSN: 1677-5538</identifier><identifier>ISSN: 1677-6119</identifier><identifier>EISSN: 1677-6119</identifier><identifier>EISSN: 1677-5538</identifier><identifier>DOI: 10.1590/1677-553820133806802</identifier><identifier>PMID: 23302400</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Urologia</publisher><subject>Administration, Topical ; Anatomy and histology ; Betamethasone - therapeutic use ; Child ; Child, Preschool ; Circumcision ; Elastic Tissue - drug effects ; Elastic Tissue - pathology ; Foreskin - drug effects ; Foreskin - pathology ; Glucocorticoids - therapeutic use ; Histology ; Humans ; Hyaluronoglucosaminidase - therapeutic use ; Male ; Methods ; Phimosis ; Phimosis - drug therapy ; Phimosis - pathology ; Time Factors ; Treatment Failure</subject><ispartof>International Brazilian Journal of Urology, 2012-12, Vol.38 (6), p.802-808</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-c41c302e5c0e68a68668a255db4fb4bb28c45626aa1bff9e00bff68a7970dd233</citedby><cites>FETCH-LOGICAL-c425t-c41c302e5c0e68a68668a255db4fb4bb28c45626aa1bff9e00bff68a7970dd233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23302400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Favorito, Luciano Alves</creatorcontrib><creatorcontrib>Balassiano, Carlos M</creatorcontrib><creatorcontrib>Rosado, João Pedro</creatorcontrib><creatorcontrib>Cardoso, Luiz Eduardo M</creatorcontrib><creatorcontrib>Costa, Waldemar Silva</creatorcontrib><creatorcontrib>Sampaio, Francisco José Barcellos</creatorcontrib><title>Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis</title><title>International Brazilian Journal of Urology</title><addtitle>Int Braz J Urol</addtitle><description>To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase.
We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%) + hyaluronidase. The parents of seven of these patients opted for circumcision (control group). The other fifty-three patients were submitted to clinical treatment. The samples were stained with Weigert's resorcin-fuchsin (analysis of the elastic fibers) and Picro-Sirius Red, for analysis of the collagen. The volumetric density of the elastic fibers was determined by stereological methods.
Only eight (15 %) of the fifty-three patients submitted to topical treatment presented failure, being indicated for circumcision (histological analysis). We observed an increase of the collagen type III of the patients submitted to topical treatment. The quantification showed a reduction of the volumetric density of the prepuce's elastic fibers of the patients submitted to the cream treatment, when compared to the control group (p = 0.056). The volumetric density of the elastic fibers of the prepuce at the group not submitted to topical treatment showed an average of 14.60% (11.06 to 21.64%); in the group submitted to the cream treatment, the volumetric density of the elastic fibers of the prepuce showed an average of 10.34% (3.45 to 17.9%).
The topical treatment of phimosis with betamethasone 0.2 % + hyaluronidase had a success rate of 85 %. Patients with failure of the topical treatment with steroid had histological alterations in the prepuce.</description><subject>Administration, Topical</subject><subject>Anatomy and histology</subject><subject>Betamethasone - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Circumcision</subject><subject>Elastic Tissue - drug effects</subject><subject>Elastic Tissue - pathology</subject><subject>Foreskin - drug effects</subject><subject>Foreskin - pathology</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Histology</subject><subject>Humans</subject><subject>Hyaluronoglucosaminidase - therapeutic use</subject><subject>Male</subject><subject>Methods</subject><subject>Phimosis</subject><subject>Phimosis - drug therapy</subject><subject>Phimosis - pathology</subject><subject>Time Factors</subject><subject>Treatment Failure</subject><issn>1677-5538</issn><issn>1677-6119</issn><issn>1677-6119</issn><issn>1677-5538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpdUctOwzAQtBCI8voDhPwDhbUTO8kRVTwqVeIAnKONs6ZGSRM5Doi_x01LD1x2vTs7Y6-HsWsBt0IVcCd0ls2VSnIJIkly0DnII3Y2tbUQxfH-vB2ZsfNh-ASQBWTilM1kkoBMAc7Y12vwowmjx4bjBpufwQ28szysifdr13bBGd576kdD3G14j8HRJgz824U1t-gaqnnoemeiQPCEoY0wN13bo4_QNDZuJiSWk2S84pKdWGwGutrnC_b--PC2eJ6vXp6Wi_vV3KRShRiFiS8lZYB0jjrXMUql6iq1VVpVMjep0lIjisraggBiiiNZkUFdxy0v2HKnW3f4Wfbeteh_yg5dOTU6_1Gijys2VNaKLKVGEQlIEU0l8spSJgGlBkh01Ep3WsZ3w-DJHvQElFtLyu1_l_8sibSbHa0fq5bqA-nPg-QXZE-J8w</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Favorito, Luciano Alves</creator><creator>Balassiano, Carlos M</creator><creator>Rosado, João Pedro</creator><creator>Cardoso, Luiz Eduardo M</creator><creator>Costa, Waldemar Silva</creator><creator>Sampaio, Francisco José Barcellos</creator><general>Sociedade Brasileira de Urologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20121201</creationdate><title>Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis</title><author>Favorito, Luciano Alves ; Balassiano, Carlos M ; Rosado, João Pedro ; Cardoso, Luiz Eduardo M ; Costa, Waldemar Silva ; Sampaio, Francisco José Barcellos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-c41c302e5c0e68a68668a255db4fb4bb28c45626aa1bff9e00bff68a7970dd233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Topical</topic><topic>Anatomy and histology</topic><topic>Betamethasone - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Circumcision</topic><topic>Elastic Tissue - drug effects</topic><topic>Elastic Tissue - pathology</topic><topic>Foreskin - drug effects</topic><topic>Foreskin - pathology</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Histology</topic><topic>Humans</topic><topic>Hyaluronoglucosaminidase - therapeutic use</topic><topic>Male</topic><topic>Methods</topic><topic>Phimosis</topic><topic>Phimosis - drug therapy</topic><topic>Phimosis - pathology</topic><topic>Time Factors</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Favorito, Luciano Alves</creatorcontrib><creatorcontrib>Balassiano, Carlos M</creatorcontrib><creatorcontrib>Rosado, João Pedro</creatorcontrib><creatorcontrib>Cardoso, Luiz Eduardo M</creatorcontrib><creatorcontrib>Costa, Waldemar Silva</creatorcontrib><creatorcontrib>Sampaio, Francisco José Barcellos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International Brazilian Journal of Urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Favorito, Luciano Alves</au><au>Balassiano, Carlos M</au><au>Rosado, João Pedro</au><au>Cardoso, Luiz Eduardo M</au><au>Costa, Waldemar Silva</au><au>Sampaio, Francisco José Barcellos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis</atitle><jtitle>International Brazilian Journal of Urology</jtitle><addtitle>Int Braz J Urol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>38</volume><issue>6</issue><spage>802</spage><epage>808</epage><pages>802-808</pages><issn>1677-5538</issn><issn>1677-6119</issn><eissn>1677-6119</eissn><eissn>1677-5538</eissn><abstract>To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase.
We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%) + hyaluronidase. The parents of seven of these patients opted for circumcision (control group). The other fifty-three patients were submitted to clinical treatment. The samples were stained with Weigert's resorcin-fuchsin (analysis of the elastic fibers) and Picro-Sirius Red, for analysis of the collagen. The volumetric density of the elastic fibers was determined by stereological methods.
Only eight (15 %) of the fifty-three patients submitted to topical treatment presented failure, being indicated for circumcision (histological analysis). We observed an increase of the collagen type III of the patients submitted to topical treatment. The quantification showed a reduction of the volumetric density of the prepuce's elastic fibers of the patients submitted to the cream treatment, when compared to the control group (p = 0.056). The volumetric density of the elastic fibers of the prepuce at the group not submitted to topical treatment showed an average of 14.60% (11.06 to 21.64%); in the group submitted to the cream treatment, the volumetric density of the elastic fibers of the prepuce showed an average of 10.34% (3.45 to 17.9%).
The topical treatment of phimosis with betamethasone 0.2 % + hyaluronidase had a success rate of 85 %. Patients with failure of the topical treatment with steroid had histological alterations in the prepuce.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Urologia</pub><pmid>23302400</pmid><doi>10.1590/1677-553820133806802</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1677-5538 |
| ispartof | International Brazilian Journal of Urology, 2012-12, Vol.38 (6), p.802-808 |
| issn | 1677-5538 1677-6119 1677-6119 1677-5538 |
| language | eng |
| recordid | cdi_crossref_primary_10_1590_1677_553820133806802 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Topical Anatomy and histology Betamethasone - therapeutic use Child Child, Preschool Circumcision Elastic Tissue - drug effects Elastic Tissue - pathology Foreskin - drug effects Foreskin - pathology Glucocorticoids - therapeutic use Histology Humans Hyaluronoglucosaminidase - therapeutic use Male Methods Phimosis Phimosis - drug therapy Phimosis - pathology Time Factors Treatment Failure |
| title | Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T07%3A43%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20analysis%20of%20the%20phimotic%20prepuce%20in%20patients%20with%20failed%20topical%20treatment%20compared%20with%20untreated%20phimosis&rft.jtitle=International%20Brazilian%20Journal%20of%20Urology&rft.au=Favorito,%20Luciano%20Alves&rft.date=2012-12-01&rft.volume=38&rft.issue=6&rft.spage=802&rft.epage=808&rft.pages=802-808&rft.issn=1677-5538&rft.eissn=1677-6119&rft_id=info:doi/10.1590/1677-553820133806802&rft_dat=%3Cpubmed_doaj_%3E23302400%3C/pubmed_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23302400&rft_doaj_id=oai_doaj_org_article_d5efe4c5ee104aacb18bfe720a260036&rfr_iscdi=true |